Plasma Renin Response to Treadmill Exercise in Secondary Hypertension Kidney Disease Patients

Abstract

Inhibition of renin activity has long been considered to be the logical step to interrupt the renin angiotensin aldosterone system which becomes the cornerstone to retard the progression of Chronic Kidney Disease. Currently, little is known about the impact of aerobic exercise on the plasma renin in chronic kidney disease patients. Aim of this study was to investigate the influence of aerobic exercise on plasma renin in the chronic kidney disease patients with secondary hypertension. Forty chronic kidney disease patients aged 40-55 years were randomly assigned to study group and control group. Study group performed moderate intensity aerobic exercise on an electronic treadmill for 30 minutes, 3 times per week, for 8 weeks. Control group received their medication only and no changes in their life style during the same trail period. The mean values for patients in groups A and B after the study were as following: For Plasma renin level (0.82 ± 0.214) and (2.09 ± 0.468) respectively, for systolic blood pressure (152.1 ± 4.86) and (155.8 ± 5.16) mmHg respectively, for diastolic blood pressure (95 ± 3.81) and (102.6 ± 6.93) mmHg respectively and for 6-minute walk test speed (1.83 ± 0.07) and (1.68 ± 0.06) m/s respectively. There were significant differences between two groups in their Plasma renin level and blood pressure (systolic and diastolic) and 6-minute walk test speed after the study. It was concluded that moderate aerobic exercise resulted in improved kidney functions with chronic kidney disease in pre-dialysis patients as reducing plasma renin and improving the blood pressure with non-significant negative weak correlation between Plasma renin level and blood pressure and a significant moderate negative correlation between exercise improvement and plasma renin.