Plasma resistin levels are associated with homocysteine, endothelial activation, and nitrosative stress in obese youths

Codoñer‐Franch, Pilar; Tavárez-Alonso, Sandra; Porcar-Almela, Manuel; Navarro-Solera, María; Arilla-Codoñer, Ángela; Alonso‐Iglesias, Eulalia

doi:10.1016/j.clinbiochem.2013.10.021

Cited by 22 publications

(12 citation statements)

References 34 publications

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“…Clinical studies have noted the role of IL-1β as an inflammatory cytokine in healthy and unhealthy obese people, as well as patients without obesity (23). Some physiological and preinflammatory effects of IL-1β emerge directly or in combination with other inflammatory mediators.…”

Section: Discussionmentioning

confidence: 99%

The Modifying Impact of Long-Term Endurance Training on Inflammatory Cytokine IL-1B Level and VO2max in Premenopausal Women with Abdominal Obesity

Behboudi

Eizadi

2017

Jundishapur J Chronic Dis Care

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Section: Discussionmentioning

confidence: 99%

The Modifying Impact of Long-Term Endurance Training on Inflammatory Cytokine IL-1B Level and VO2max in Premenopausal Women with Abdominal Obesity

Behboudi

Eizadi

2017

Jundishapur J Chronic Dis Care

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“…Nitrative/nitrosative stress, known to be associated with oxidative stress (3,9) , has been evaluated in some studies by measuring systemic 3-nitrotyrosine, a marker of tyrosine nitration by peroxynitrite (3,9) , and also by quantification of markers of NO formation and metabolism, such as plasmatic and urinary nitrates and nitrites (P-NOx or U-NOx) (9,10) , but contradictory results have been reported concerning whether obese children present increased or decreased levels of these markers (9)(10)(11) . In two studies of Codoñer-Franch et al, obese children, with an age range from 7 to 14 years, exhibited higher levels of plasma and/urinary NO markers, whereas a reduction in serum nitrate and nitrite concentrations was observed in another study involving adolescents with a mean age of 14 years (9)(10)(11) .…”

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confidence: 99%

Oxidative stress and nitric oxide are increased in obese children and correlate with cardiometabolic risk and renal function

et al. 2016

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Oxidative stress and nitric oxide (NO) appear to represent important links between obesity and cardiovascular, metabolic and/or renal disease. We investigated whether oxidative stress and NO production/metabolism are increased in overweight and obese prepubertal children and correlate with cardiometabolic risk and renal function. We performed a cross-sectional evaluation of 313 children aged 8-9 years. Anthropometrics, 24-h ambulatory blood pressure, pulse wave velocity (PWV), insulin resistance (homoeostasis model assessment index (HOMA-IR)), inflammatory/metabolic biomarkers, estimated glomerular filtration rate (eGFR), plasma total antioxidant status (TAS), plasma and urinary isoprostanes (P-Isop, U-Isop), urinary hydrogen peroxide (U-H 2 O 2 ), and plasma and urinary nitrates and nitrites (P-NOx, U-NOx) were compared among normal weight, overweight and obese groups, according to WHO BMI z-score reference. U-Isop were increased in the obese group, whereas U-NOx were increased in both overweight and obese children. U-Isop were positively correlated with U-H 2 O 2 , myeloperoxidase (MPO), high-sensitivity C-reactive protein, HOMA-IR and TAG. TAS correlated negatively with U-Isop and MPO and positively with PWV. HOMA-IR and U-H 2 O 2 were associated with higher U-Isop, independently of BMI and eGFR, and total cholesterol and U-H 2 O 2 were associated with U-NOx, independently of BMI, eGFR values and P-NOx concentration. In overweight and obese children, eGFR decreased across P-NOx tertiles (median: 139·3 (25th, 75th percentile 128·0, 146·5), 128·0 (25th, 75th percentile 121·5, 140·4), 129·5 (25th, 75th percentile 119·4, 138·3), P for linear trend = 0·003). We conclude that oxidant status and NO are increased Abbreviations: ABPM, ambulatory blood pressure monitoring; eGFR, estimated glomerular filtration rate; HOMA-IR, homoeostasis model assessment of insulin resistance; hs-CRP, high-sensitivity C-reactive protein; MAP, mean arterial pressure; MPO, myeloperoxidase; NO, nitric oxide; NOS, NO synthase; P-Isop, plasma isoprostanes; P-NOx, plasma nitrates and nitrites; PWV, pulse wave velocity; ROS, reactive oxygen species; TAS, total antioxidant status; U-H 2 O 2 , urinary hydrogen peroxide; U-Isop, urinary isoprostanes; U-NOx, urinary nitrates and nitrites; WHtR, waist:height ratio.

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“…In obese children and hypertensive T2DM patients, resistin serum levels were correlated positively with markers of endothelial activation (ICAM-1, VCAM-1 and E-selectin), homocysteine, and oxidative/nitrosative stress Endocrine [283,284]. Furthermore, serum resistin level is associated with CRP in T2DM patients [285].…”

Section: Resistinmentioning

confidence: 99%

Insights into the molecular mechanisms of diabetes-induced endothelial dysfunction: focus on oxidative stress and endothelial progenitor cells

et al. 2015

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Diabetes mellitus is a heterogeneous, multifactorial, chronic disease characterized by hyperglycemia owing to insulin insufficiency and insulin resistance (IR). Recent epidemiological studies showed that the diabetes epidemic affects 382 million people worldwide in 2013, and this figure is expected to be 600 million people by 2035. Diabetes is associated with microvascular and macrovascular complications resulting in accelerated endothelial dysfunction (ED), atherosclerosis, and cardiovascular disease (CVD). Unfortunately, the complex pathophysiology of diabetic cardiovascular damage is not fully understood. Therefore, there is a clear need to better understand the molecular pathophysiology of ED in diabetes, and consequently, better treatment options and novel efficacious therapies could be identified. In the light of recent extensive research, we re-investigate the association between diabetes-associated metabolic disturbances (IR, subclinical inflammation, dyslipidemia, hyperglycemia, dysregulated production of adipokines, defective incretin and gut hormones production/action, and oxidative stress) and ED, focusing on oxidative stress and endothelial progenitor cells (EPCs). In addition, we re-emphasize that oxidative stress is the final common pathway that transduces signals from other conditions-either directly or indirectly-leading to ED and CVD.

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Plasma resistin levels are associated with homocysteine, endothelial activation, and nitrosative stress in obese youths

Cited by 22 publications

References 34 publications

The Modifying Impact of Long-Term Endurance Training on Inflammatory Cytokine IL-1B Level and VO2max in Premenopausal Women with Abdominal Obesity

The Modifying Impact of Long-Term Endurance Training on Inflammatory Cytokine IL-1B Level and VO2max in Premenopausal Women with Abdominal Obesity

Oxidative stress and nitric oxide are increased in obese children and correlate with cardiometabolic risk and renal function

Insights into the molecular mechanisms of diabetes-induced endothelial dysfunction: focus on oxidative stress and endothelial progenitor cells

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