Plasma Selenium Concentrations Are Sufficient and Associated with Protease Inhibitor Use in Treated HIV-Infected Adults

Hileman, Corrilynn Olesky; Dirajlal-Fargo, Sahera; Lam, Suet Kam; Kumar, Jessica; Lacher, Craig; Combs, Gerald F.; McComsey, Grace A.

doi:10.3945/jn.115.214577

Cited by 14 publications

(9 citation statements)

References 47 publications

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“…An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure, reminiscent of the dilated cardiomyopathies seen with selenium deficiency [23]. In HIV-infected adults with rosuvastatin treatment, over 48 weeks, Se concentrations increased significantly in the rosuvastatin group [24]. The reason for the inconsistency between our study and this study may be due to the different duration of treatment with statin.…”

Section: Discussionmentioning

confidence: 82%

Serum and Urinary Selenium Status in Patients with the Pre-diabetes and Diabetes in Northeast China

Zhou

Guo

Jia

et al. 2018

Biol Trace Elem Res

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Homeostasis imbalance of selenium (Se) in diabetes has received great attention. This study investigated serum and urinary Se levels in patients with impaired fasting glucose (IFG), impaired glucose tolerance (IGT), type 1 diabetes (T1D), and type 2 diabetes (T2D) in Northeast Chinese populations. From January 2010 to October 2011, patients with IFG ( n = 12), IGT ( n = 15), T1D ( n = 25), T2D ( n = 137), and healthy controls ( n = 50) were enrolled in the First Hospital of Jilin University. Se was detected using inductively coupled plasma spectrometer. The serum Se level was dramatically lower in patients with T1D and was significantly higher in IFG subjects, and the urinary Se concentration was markedly lower in IGT and T2D groups. The serum Se levels were positively correlated with serum zinc (Zn) in both IFG and IGT groups, while urinary Se were positively associated with urinary Zn and copper (Cu) in IGT group. The serum Se levels were positively correlated with serum Cu in both T1D and T2D groups, and urinary levels of Se were positively associated with serum zinc and urinary Cu, Zn, calcium (Ca), and magnesium (Mg) and negatively correlated with serum Ca and Mg in T2D group, while the urinary levels of Se were positively correlated with urinary Zn and Mg both in peripheral neuropathy (DPN) and retinopathy (DR) groups. One month of simvastatin therapy reduced serum Se levels. These results suggest the potential role of Se in diabetes should receive attention.

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Section: Discussionmentioning

confidence: 82%

Serum and Urinary Selenium Status in Patients with the Pre-diabetes and Diabetes in Northeast China

Zhou

Guo

Jia

et al. 2018

Biol Trace Elem Res

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“…Thus, it is difficult to directly compare studies using different selenium status readouts [ 143 ]. Anti-retroviral therapies may also confound the selenium status [ 144 , 145 ]. However, some studies have not supported this notion [ 146 ].…”

Section: Immune Responses To Pathogensmentioning

confidence: 99%

Selenium, Selenoproteins, and Immunity

2018

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Selenium is an essential micronutrient that plays a crucial role in development and a wide variety of physiological processes including effect immune responses. The immune system relies on adequate dietary selenium intake and this nutrient exerts its biological effects mostly through its incorporation into selenoproteins. The selenoproteome contains 25 members in humans that exhibit a wide variety of functions. The development of high-throughput omic approaches and novel bioinformatics tools has led to new insights regarding the effects of selenium and selenoproteins in human immuno-biology. Equally important are the innovative experimental systems that have emerged to interrogate molecular mechanisms underlying those effects. This review presents a summary of the current understanding of the role of selenium and selenoproteins in regulating immune cell functions and how dysregulation of these processes may lead to inflammation or immune-related diseases.

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“…In a cross-sectional study involving children with perinatally acquired HIV on stable ART for ≥6 mo, higher plasma selenium concentrations were associated with lower systemic inflammation and more elevated gut integrity markers (123). The plasma selenium concentration was associated with a higher proportion of T-cell activation (124) whereas zinc supplementation, in a pilot study, increased circulating zinc concentrations and modulated biomarkers associated with clinical comorbidities in HIV-positive adults (125). In a randomized, double-blind, placebo-controlled trial in infants (aged 6 wk, baseline) born to HIV-positive mothers in Tanzania, Liu et al (126) found that daily multivitamin supplementation (vitamin B complex, C and E) improved the children's hematologic status after 24 mo of intervention compared to a placebo group.…”

Section: Micronutrient Supplementationmentioning

confidence: 94%

Nutrition in HIV-Infected Infants and Children: Current Knowledge, Existing Challenges, and New Dietary Management Opportunities

Fabusoro

Mejía

2021

Advances in Nutrition

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HIV infection and undernutrition remain significant public health concerns for infants and children. In infants and children under these conditions, undernutrition is one of the leading causes of death. Proper management of nutrition and related nutrition complications in these groups with increased nutrition needs are prominent challenges, particularly in HIV-prevalent poor-resource environments. Several studies support the complexity of the relation between HIV infection, nutrition, and the immune system. These elements interact and create a vicious circle of poor health outcomes. Recent studies on the use of probiotics as a novel approach to manage microbiome imbalance and gut-mucosal impairment in HIV infection are gaining attention. This new strategy could help to manage dysbiosis and gut-mucosal impairment by reducing immune activation, thereby potentially forestalling unwanted health outcomes in children with HIV. However, existing trials on HIV-infected children are still insufficient. There are also conflicting reports on the dosage and effectiveness of single or multiple micronutrient supplementation in the survival of HIV-infected children with severe acute malnutrition. The WHO has published guidelines that include time of initiation of antiretroviral therapy for HIV-pregnant mothers and their HIV-exposed or HIV-infected children, micronutrient supplementation, dietary formulations, prevention, and management of HIV therapy. However, such guidelines need to be reviewed owing to recent advances in the field of nutrition. There is a need for new intervention studies, practical strategies, and evidence-based guidelines to reduce the disease burden, improve adherence to treatment regimen, and enhance the nutrition, health, and well-being of HIV-infected infants and children. This review provides up-to-date scientific information on current knowledge and existing challenges for nutrition therapy in HIV-infected infants and children. Moreover, it presents new research findings that could be incorporated into current guidelines.

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Plasma Selenium Concentrations Are Sufficient and Associated with Protease Inhibitor Use in Treated HIV-Infected Adults

Cited by 14 publications

References 47 publications

Serum and Urinary Selenium Status in Patients with the Pre-diabetes and Diabetes in Northeast China

Serum and Urinary Selenium Status in Patients with the Pre-diabetes and Diabetes in Northeast China

Selenium, Selenoproteins, and Immunity

Nutrition in HIV-Infected Infants and Children: Current Knowledge, Existing Challenges, and New Dietary Management Opportunities

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