Plasma serotonin levels are elevated in pregnant women with hyperemesis gravidarum

Cengiz, Hüseyin; Dağdeviren, Hediye; Çaypınar, Sema Süzen; Kanawati, Ammar; Yıldız, Şükrü; Ekin, Murat

doi:10.1007/s00404-014-3572-2

Cited by 14 publications

(13 citation statements)

References 21 publications

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“…Our data on the pregnancy-increased cerebellar content of tryptophan are in line with the activation of serotonergic signaling observed during pregnancy, because tryptophan is the serotonin precursor [36]. The interaction between the levels of serotonin and estrogens also underlies sex-dimorphic prevalence of the serotonin-linked diseases, including migraine, depression, eating disorders and pregnancy-associated pathologies [36,37].…”

Section: Discussionsupporting

confidence: 84%

“…Because these amino acids are highly correlated independent of pregnancy and/or hypoxia (Table 3), metabolism of cerebellar lysine appears to be a more likely contributor to specific adaptations imposed by pregnancy. This is further supported by the fact that lysine is known as an antagonist of a serotonin receptor [60], with serotonergic signaling increased in pregnancy [36,37] and depressed upon increased synthesis of homoarginine from lysine [61].…”

Section: Discussionmentioning

confidence: 91%

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Hypoxic Adaptation of Mitochondrial Metabolism in Rat Cerebellum Decreases in Pregnancy

Граф

Trofimova

Ksenofontov

et al. 2020

Cells

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Function of brain amino acids as neurotransmitters or their precursors implies changes in the amino acid levels and/or metabolism in response to physiological and environmental challenges. Modelling such challenges by pregnancy and/or hypoxia, we characterize the amino acid pool in the rat cerebellum, quantifying the levels and correlations of 15 amino acids and activity of 2-oxoglutarate dehydrogenase complex (OGDHC). The parameters are systemic indicators of metabolism because OGDHC limits the flux through mitochondrial TCA cycle, where amino acids are degraded and their precursors synthesized. Compared to non-pregnant state, pregnancy increases the cerebellar content of glutamate and tryptophan, decreasing interdependence between the quantified components of amino acid metabolism. In response to hypoxia, the dependence of cerebellar amino acid pool on OGDHC and the average levels of arginine, glutamate, lysine, methionine, serine, phenylalanine, and tryptophan increase in non-pregnant rats only. This is accompanied by a higher hypoxic resistance of the non-pregnant vs. pregnant rats, pointing to adaptive significance of the hypoxia-induced changes in the cerebellar amino acid metabolism. These adaptive mechanisms are not effective in the pregnancy-changed metabolic network. Thus, the cerebellar amino acid levels and OGDHC activity provide sensitive markers of the physiology-dependent organization of metabolic network and its stress adaptations.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 91%

Hypoxic Adaptation of Mitochondrial Metabolism in Rat Cerebellum Decreases in Pregnancy

Граф

Trofimova

Ksenofontov

et al. 2020

Cells

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“…Hyperemesis gravidarum is a severe form of nausea and vomiting in pregnant women, and elevated serotonin level is found associated with hyperemesis gravidarum and PONV as well. 18 In our study, WBC, HGB, N and L counts, N/L ratio, RBC, MCV, MCH, MCHC and RDW had similar values for both the POV and control groups. According to our results, these parameters provide predictable information for POV.…”

Section: Discussionsupporting

confidence: 69%

The role of platelet count, mean platelet volume, and the mean platelet volume/platelet count ratio in predicting postoperative vomiting in children after deep sedation

Canpolat

Doğruel

Gönen

et al. 2016

SMJ

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Objectives:To determine the role of hemogram parameters such as platelet count (PLT), mean platelet volume (MPV), and the MPV/PLT ratio in predicting the risk of postoperative vomiting (POV) in children after tooth extraction under deep sedation.Methods:A total of 100 American Society of Anesthesiology Classification I and II pediatric patients who underwent tooth extraction procedures under a standard anesthetic method were included in the study between 2012 and 2014. The study took place at the Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Erciyes University, Erciyes, Turkey Fifty patients without POV (group 1) and 50 patients with POV (group 2) were retrospectively selected randomly from the records of 885 consecutive patients. Age, gender, duration of the operation, and preoperative hemogram findings were recorded.Results:There was a statistically significant difference between the 2 groups in terms of MPV (p<0.001), PLT (p=0.006), and MPV/PLT (p<0.001) ratio. Mean platelet volume and MPV/PLT ratio were higher in group 2, whereas PLT was higher in group 1.Conclusion:The PLT count, MPV, and MPV/PLT ratio may be used to predict POV in children.

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“…An analysis of insurance data of 11,016 women who gave birth found that a pre-pregnancy psychiatric diagnosis doubled the risk of developing HG and pre-pregnancy psychiatric and somatic conditions quadrupled the risk, which suggest that these disorders, or a common etiologic factor, may play a role in the development of HG in some women (Seng et al 2007). Women with HG have been found to have significantly higher levels of plasma serotonin compared to women with N/V of pregnancy and pregnant controls (Cengiz et al 2015).…”

Section: Pathogenesismentioning

confidence: 97%

Treatment options for hyperemesis gravidarum

Abramowitz

Miller

Wisner

2017

Arch Womens Ment Health

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Hyperemesis gravidarum (HG) is a severe and prolonged form of nausea and/or vomiting during pregnancy. HG affects 0.3-2% of pregnancies and is defined by dehydration, ketonuria, and more than 5% body weight loss. Initial pharmacologic treatment for HG includes a combination of doxylamine and pyridoxine. Additional interventions include ondansetron or dopamine antagonists such as metoclopramide or promethazine. The options are limited for women who are not adequately treated with these medications. We suggest that mirtazapine is a useful drug in this context and its efficacy has been described in case studies. Mirtazapine acts on noradrenergic, serotonergic, histaminergic, and muscarinic receptors to produce antidepressant, anxiolytic, antiemetic, sedative, and appetite-stimulating effects. Mirtazapine is not associated with an independent increased risk of birth defects. Further investigation of mirtazapine as a treatment for HG holds promise to expand treatment options for women suffering from HG.

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Plasma serotonin levels are elevated in pregnant women with hyperemesis gravidarum

Abstract: Our findings support the possible role of serotonin in the pathogenesis of hyperemesis gravidarum.

Cited by 14 publications

References 21 publications

Hypoxic Adaptation of Mitochondrial Metabolism in Rat Cerebellum Decreases in Pregnancy

Hypoxic Adaptation of Mitochondrial Metabolism in Rat Cerebellum Decreases in Pregnancy

The role of platelet count, mean platelet volume, and the mean platelet volume/platelet count ratio in predicting postoperative vomiting in children after deep sedation

Treatment options for hyperemesis gravidarum

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