Plasma somatostatin-like immunoreactivity increases in the plasma of septic patients and rats with systemic inflammatory reaction: Experimental evidence for its sensory origin and protective role

Sütő, Balázs; Szitter, István; Bagoly, Teréz; Pintér, Erika; Szolcsányi, Janós; Loibl, Csaba; Németh, Timea; Tánczos, Krisztián; Molnár, Tihamér; Leiner, Tamás; Varnai, Bianka; Bardonicsek, Zsofia; Helyes, Zsuzsanna

doi:10.1016/j.peptides.2014.01.006

Cited by 5 publications

(6 citation statements)

References 54 publications

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“…Therefore, we hypothesized that its release might be an adaptive mechanism aimed at alleviating pain and reducing tissue damage. These observations are in agreement with earlier human data findings in other types of abdominal, thoracic, and orthopaedic surgeries and systemic inflammation (sepsis) demonstrating plasma SST-LI elevations [ 3 , 12 , 13 , 24 ]. The studies have reported findings indicating a noticeable yet statistically significant increase of approximately 10% in SST-LI within the systemic circulation following laparoscopic cholecystectomy, inguinal hernia repair, and abdominal wall hernia repairs [ 24 ].…”

Section: Discussionsupporting

confidence: 93%

“…After a calibration method the actual concentration of the substance can be measured. Plasma SST-LI was determined with a specific and sensitive RIA technique developed and validated by us as described earlier in detail [ 12 , 13 , 26 ]. We employed a C-terminal sensitive antiserum specific to SST-14, which demonstrated its ability to bind both biologically active forms of SST containing 14 and 28 amino acids.…”

Section: Methodsmentioning

confidence: 99%

“…We have shown earlier both in animal models and humans that SST is released from the capsaicin-sensitive afferents in response to inflammatory processes (arthritis, sepsis) and tissue damage (e.g., surgery) [ 12 , 13 ]. Data obtained in experiments conducted on rats, mice, and guinea pigs demonstrated that the released SST does not only interact with inflammatory cells locally, but also enters the systemic circulation.…”

Section: Introductionmentioning

confidence: 99%

“…Exogenous SST and its synthetic analogues reduce both neurogenic and non-neurogenic inflammatory and nociceptive mechanisms [ 17 , 18 , 19 , 20 ], as well as inhibit the severity and increase the survival rate of experimental sepsis [ 21 , 22 , 23 ]. In addition to all these extensive animal experimental investigations, we demonstrated in humans that the plasma SST level increases during and after abdominal [ 24 ], thoracic, and some orthopaedic surgical interventions, as well as in sepsis [ 12 , 13 , 25 ]. These data might suggest a general endogenous protective mechanism mediated by SST released from the capsaicin-sensitive nerves.…”

Section: Introductionmentioning

confidence: 99%

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Plasma Somatostatin Levels Increase during Scoliosis Surgery, but Not Herniated Disc Operations: Results of a Pilot Study

Sütő,

Kolumbán,

Szabó

et al. 2023

Biomedicines

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Somatostatin (SST) released from capsaicin-sensitive sensory nerves in response to stimulation exerts systemic anti-inflammatory, analgesic actions. Its elevation correlates with the extent of tissue injury. We measured plasma SST alterations during spine operations (scoliosis and herniated disc) to determine whether its release might be a general protective mechanism during painful conditions. Sampling timepoints were baseline (1), after: soft tissue retraction (2), osteotomy (3), skin closure (4), the following morning (5). Plasma SST-like immunoreactivity (SST-LI) determined by radioimmunoassay was correlated with pain intensity and the correction angle (Cobb angle). In scoliosis surgery, postoperative pain intensity (VAS 2.) 1 day after surgery significantly increased (from 1.44 SEM ± 0.68 to 6.77 SEM ± 0.82, p = 0.0028) and positively correlated with the Cobb angle (p = 0.0235). The baseline Cobb degree negatively correlated (p = 0.0459) with the preoperative SST-LI. The plasma SST-LI significantly increased in fraction 3 compared to the baseline (p < 0.05), and significantly decreased thereafter (p < 0.001). In contrast, in herniated disc operations no SST-LI changes were observed in either group. The VAS decreased after surgery both in the traditional (mean 6.83 to 2.29, p = 0.0005) and microdiscectomy groups (mean 7.22 to 2.11, p = 0.0009). More extensive and destructive scoliosis surgery might cause greater tissue damage with greater pain (inflammation), which results in a significant SST release into the plasma from the sensory nerves. SST is suggested to be involved in an endogenous postoperative analgesic (anti-inflammatory) mechanism.

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Section: Discussionsupporting

confidence: 93%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Plasma Somatostatin Levels Increase during Scoliosis Surgery, but Not Herniated Disc Operations: Results of a Pilot Study

Sütő,

Kolumbán,

Szabó

et al. 2023

Biomedicines

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“…The influx of divalent cations (particularly Ca 2+ ) after TRPV1 activation results in nerve depolarization and concomitant release of the neuropeptides calcitonin gene-related peptide (CGRP), somatostatin, and substance P from the sensory nerve terminals (21). CGRP (22) and somatostatin (23) are anti-inflammatory, whereas substance P is proinflammatory (24).…”

mentioning

confidence: 99%

Endogenously generated arachidonate‐derived ligands for TRPV1 induce cardiac protection in sepsis

et al. 2018

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The severity of cardiac dysfunction predicts mortality in sepsis. Activation of transient receptor potential vanilloid receptor type (TRPV)-1, a predominantly neuronal nonselective cation channel, has been shown to improve outcome in sepsis and endotoxemia. However, the role of TRPV1 and the identity of its endogenous ligands in the cardiac dysfunction caused by sepsis and endotoxemia are unknown. Using TRPV1 and TRPV1 mice, we showed that endogenous activation of cardiac TRPV1 during sepsis is key to limiting the ensuing cardiac dysfunction. Use of liquid chromatography-tandem mass spectrometry lipid analysis and selective inhibitors of arachidonic metabolism suggest that the arachidonate-derived TRPV1 activator, 20-hydroxyeicosateraenoic acid (20-HETE), underlies a substantial component of TRPV1-mediated cardioprotection in sepsis. Moreover, using selective antagonists for neuropeptide receptors, we show that this effect of TRPV1 relates to the activity of neuronally released cardiac calcitonin gene-related peptide (CGRP) and that, accordingly, administration of CGRP can rescue cardiac dysfunction in severe endotoxemia. In sum activation of TRPV1 by 20-HETE leads to the release of CGRP, which protects the heart against the cardiac dysfunction in endotoxemia and identifies both TRPV1 and CGRP receptors as potential therapeutic targets in endotoxemia.-Chen, J., Hamers, A. J. P., Finsterbusch, M., Massimo, G., Zafar, M., Corder, R., Colas, R. A., Dalli, J., Thiemermann, C., Ahluwalia, A. Endogenously generated arachidonate-derived ligands for TRPV1 induce cardiac protection in sepsis.

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Drug effects on neuropeptides and their receptors: Big hopes but moderate success in the treatment of chronic pain

Borbély,

Pethő

2024

Current Opinion in Pharmacology

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Plasma somatostatin-like immunoreactivity increases in the plasma of septic patients and rats with systemic inflammatory reaction: Experimental evidence for its sensory origin and protective role

Cited by 5 publications

References 54 publications

Plasma Somatostatin Levels Increase during Scoliosis Surgery, but Not Herniated Disc Operations: Results of a Pilot Study

Plasma Somatostatin Levels Increase during Scoliosis Surgery, but Not Herniated Disc Operations: Results of a Pilot Study

Endogenously generated arachidonate‐derived ligands for TRPV1 induce cardiac protection in sepsis

Drug effects on neuropeptides and their receptors: Big hopes but moderate success in the treatment of chronic pain

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