Plasma urate concentrations and possible REM sleep behavior disorder

Shen, Yun; Li, Junjuan; Schwarzschild, Michael A.; Pavlova, Milena; He, Shan; Ascherio, Alberto; Wu, Shouling; Gao, Xiang

doi:10.1002/acn3.50929

Cited by 8 publications

(7 citation statements)

References 45 publications

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“…Residual confounding is another limitation. For example, the Kailuan Study did not collect data on depression until 2016 (32) , which was thus not adjusted in the current analysis. However, the prevalence of physician-diagnosed depression (0•13 %) was low among the Kailuan participants (32) , although it could be underdiagnosed.…”

Section: Discussionmentioning

confidence: 99%

“…For example, the Kailuan Study did not collect data on depression until 2016 (32) , which was thus not adjusted in the current analysis. However, the prevalence of physician-diagnosed depression (0•13 %) was low among the Kailuan participants (32) , although it could be underdiagnosed. Further, the Kailuan Study is located in Tangshan city, China, and included a large portion of individuals with low-to-middle education levels and low-income, which may limit the generalisability of the findings to other ethnic groups.…”

Section: Discussionmentioning

confidence: 99%

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Alcohol consumption and sleep quality: a community-based study

Zheng

Yuan

et al. 2020

Public Health Nutr.

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Objective: To assess the association between total alcohol intake, specific alcoholic beverages, and sleep quality in a community-based cohort. Design: A cross-sectional study. Setting: The Kailuan community, China. Participants: Included were 11,905 participants who were free of a history of cardiovascular diseases, cancer, Parkinson’s disease, dementia, and head injury in or prior to 2012. Alcohol consumption (amount and frequency intake) and alcoholic beverage type were collected in 2006 (baseline) and 2012. Participants were grouped into non-, light- (women: 0-0.4 serving/day; men: 0-0.9 serving/day), moderate- (women: 0.5-1.0 serving/day; men: 1.0-2.0 servings/day), and heavy- (women: >1.0 servings/day; men: >2.0 servings/day) drinker. Overall sleep quality was measured in 2012 and included four sleep parameters (insomnia, daytime sleepiness, sleep duration, snoring/obstructive sleep apnea). Results: We observed a dose-response association between higher alcohol consumption in 2006 and worse sleep quality in 2012 (P-trend <0.001), after adjusting for age, sex, social-economic status, smoking status, physical activity, obesity, plasma lipid profiles, diabetes and hypertension. A similar association was observed when alcohol consumption in 2012 was used as exposure. Alcohol was associated with higher odds of having short sleep duration (adjusted odds ratio for heavy- vs. non-drinkers = 1.32; 95% confidence interval: 1.09-1.57), and snoring (adjusted odds ratio for heavy- vs. non-drinkers: 1.38; 95% confidence interval: 1.22-1.57). Consumption of hard liquor, but not beer or wine, was significantly associated with poor sleep quality. Conclusions: Higher alcohol consumption was associated with poorer sleep quality and higher odds of having snoring and short sleep duration.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Alcohol consumption and sleep quality: a community-based study

Zheng

Yuan

et al. 2020

Public Health Nutr.

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“…[15][16][17] Because urate-elevating drugs are currently trialed after disease onset, it is vital to understand the role changing urate levels may play on disease progression. Results from observational studies have shown that lower plasma urate levels have been reported in patients with advanced-stage PD, 4 whereas inverse associations between urate levels and rate of UPDRS change in men 5 and the risk of developing RBD in a Chinese cohort 22 have been reported. However, issues with confounding and reverse causation within observational studies mean causality can never be fully established.…”

Section: Discussionmentioning

confidence: 99%

Mendelian Randomisation Finds No Causal Association between Urate and Parkinson's Disease Progression

et al. 2021

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Background Parkinson's disease (PD) is a common neurodegenerative movement disorder. Observational studies suggest higher levels of plasma urate may protect against Parkinson's risk and progression; however, causality cannot be established. Objectives This study set out to determine whether there is a true causal association between urate levels and PD age at onset (AAO) and progression severity using recently released PD AAO and progression genome‐wide association study (GWAS) data. Methods A large two‐sample Mendelian randomization design was employed, using genetic variants underlying urate levels and the latest GWAS data for PD outcomes. Results This study found no causal association between urate levels and Parkinson's risk, AAO, or progression severity. Conclusions Our results predict increasing urate levels as a therapeutic strategy is unlikely to benefit PD patients. © 2021 International Parkinson and Movement Disorder Society

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“…This scale was also used in some other studies with nice reliability and validity. 33 , 34 The scores of RBDQ-HK were analyzed in this study.…”

Section: Methodsmentioning

confidence: 99%

Associations Between Self-Reported Sleep Disturbances and Cognitive Impairment: A Population-Based Cross-Sectional Study

Sun¹,

K²,

Zhang³

et al. 2022

NSS

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Cognitive impairment is a rapidly growing global public health problem in China and worldwide. In the recent decades, emerging studies have explored the associations between sleep disturbances and cognitive impairment. However, the variety of the results imply us that further studies should be conducted for the associations. Methods: This is a cross-sectional study conducted between August and October 2018 in five cities in Hebei province, China. Subjects were 21,376 community residents. Cognitive impairment was screened by the Chinese version of the Mini-Mental State Examination (MMSE). Scales of Athens Insomnia Scale (AIS), Berlin Questionnaire (BQ), REM (rapid eye movement) Sleep Behavior Disorder Questionnaire (RBDQ-HK), Ullanlinna Narcolepsy Scale (CUNS), and Cambridge-Hopkins Restless Legs Syndrome Questionnaire (CH-RLSq) were used to access insomnia, sleep apnea, REM sleep behavior disorder, narcolepsy, and restless leg syndrome.

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Plasma urate concentrations and possible REM sleep behavior disorder

Cited by 8 publications

References 45 publications

Alcohol consumption and sleep quality: a community-based study

Alcohol consumption and sleep quality: a community-based study

Mendelian Randomisation Finds No Causal Association between Urate and Parkinson's Disease Progression

Associations Between Self-Reported Sleep Disturbances and Cognitive Impairment: A Population-Based Cross-Sectional Study

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