Plasma viscosity as an early cardiovascular risk factor in hirsute women with eumenorrhea or oligomenorrhea

Erdem, Necmiye Tijen; Ercan, Meltem; Akyolcu, Mehmet Can; Gündoğdu, Aliye

doi:10.1016/s0015-0282(03)01173-7

Cited by 20 publications

(22 citation statements)

References 27 publications

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“…IH has been previously linked with cardiovascular risk factors (6). This condition may not represent a distinct entity and may only be a milder variant of PCOS.…”

Section: Introductionmentioning

confidence: 95%

Association of dehydroepiandrosterone-sulfate with endothelial function in young women with polycystic ovary syndrome

Dagre

Lekakis²,

Mihas³

et al. 2006

eur j endocrinol

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Objective: The aim of this study was to assess non-invasively endothelial function of young women with polycystic ovary syndrome (PCOS) in comparison with healthy age-matched women and a group of young women with idiopathic hirsutism (IH). The possible role of metabolic and hormonal parameters on endothelial function was also examined. Design: Descriptive clinical trial. Methods: Fifty-six women, 27 with PCOS, 16 with IH and 13 healthy age-matched women were studied. Endothelial function of resistance arteries was assessed by venous occlusion plethysmography. Metabolic and hormonal parameters were estimated in this study population. Results: The duration of reactive hyperemia (durRH) was shorter in PCOS group when compared with normal controls (63.75G13.33 s vs 113.18G20.92 s, PZ0.036). A similar finding was observed when PCOS were compared with IH group (63.75G13.33 s vs 105G17.20 s, PZ0.05). The durRH did not differ between IH and control group (105G17.20 s vs 113.18G20.92 s, ns). A significant positive linear correlation was found between the durRH and dehydroepiandrosterone-sulfate (DHEA-S) levels (rZC0.48, PZ0.04) in the PCOS group. The basal insulin resistance index (HOMA) differed significantly between PCOS, IH and control groups. There was no significant correlation between durRH and HOMA index or testosterone levels in the PCOS group. Conclusions: Endothelial dysfunction may be an early sign of cardiovascular system abnormalities in young PCOS women. It is possible that increased DHEA-S levels may offer a cardioprotective advantage that attenuates the effects of cardiovascular risk factors that accompany PCOS.European Journal of Endocrinology 154 883-890

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“…IH has been previously linked with cardiovascular risk factors (6). This condition may not represent a distinct entity and may only be a milder variant of PCOS.…”

Section: Introductionmentioning

confidence: 95%

Association of dehydroepiandrosterone-sulfate with endothelial function in young women with polycystic ovary syndrome

Dagre

Lekakis²,

Mihas³

et al. 2006

eur j endocrinol

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“…Different parameters of lipid spectrum was found to be negatively correlated with thyroid hormones (fT3 and fT4).meanwhile positive correlation was seen with that of 34 TSH level. Like some other studies , HDL cholesterol was found to be negatively correlated with TSH but the variables observed to be not statistically significant.…”

Section: Outmentioning

confidence: 83%

“…The consent was taken from each subject and the ethical approval for the study was provided by institute review board of UCMS, Bhairahawa. Serum fT / fT4 and TSH estimations 3 4 were carried out by competitive ELISA method and Sand- 5 wich double antibody ELISA method respectively using commercially supplied reagents (Human, Germany). The criterion for dyslipidemia was obtained by National Cholesterol Education Expert Panel/ Adult Treatment Protocol III (NCEP/ATPIII).…”

Section: Methodsmentioning

confidence: 99%

Spectrum of Lipid Abnormality among Thyroid Disorder Patients in Ucms-Th, South Western Region

Gautam

Jayan

Jha

et al. 2018

J Univ Coll Med Sci

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INTRODUCTION:Hypothyroidism is the most common cause of secondary dyslipidemia. Thus, thyroid function test should be carried out before starting any hypolipidemic drugs. Even among thyroid disorder, hypothyroidism is more associated with cardiovascular and associated problems and if not detected earlier, it leads to severe clinical consequences. Our study assesses the frequency and spectrum of dyslipidemia in various types of thyroidal illness in the population residing in south western part of Nepal. MATERIALS AND METHODS:This is a cross sectional study carried out in suspected thyroid disorder patients (n=276) and categorized as Euthyroidism (n=55), Subclinical Hypothyroidism (n=89), Primary Hypothyroidism (n=122) and Primary Hyperthyroidism (n=10) patients and to see the association with lipid profiles in the Department of Biochemistry, Universal College of Medical Sciences Teaching Hospital, Bhairahawa Nepal. Serum fT / fT4 and TSH estimations were carried out by competitive 3 ELISA method and Sand-wich double antibody ELISA method respectively using commercially supplied reagents (Human, Germany). The criteria for dyslipidemia was obtained by National Cholesterol Education Expert Panel/ Adult Treatment Protocol III (NCEP/ATPIII). RESULTS:Out of 276 cases the dyslipidemia was observed in 183 cases (66.30%).The dyslipidemia was mostly associated with primary hypothyroidism (55.07%) followed by Subclinical Hypothyroidism (38.04%) than Euthyroid (5.79 %) and Primary Hyperthyroidism (3.62 %) respectively. Out of all cases, the spectrum of dyslipidemia was mostly observed for decreased HDL (18.5 %) followed by increased TG (10.1 %). Moreover, it is significantly differ in relation in HDL (p=0.009), TG/HDL (p=0.02) and Non-HDL/HDL (p=0.033) where as non significant as compared to other lipid profile in different groups. CONCLUSION:Our study revealed the close association of thyroidal illness with dyslipidemia with increased TG, low HDL, increased TG/HDL and Non-HDL/HDL. The increased TG/HDL and/or Non-HDL/HDL could be better indicator than single lipid abnormality which needs to be ascertained prospectively in large population.

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“…Case-control and cross-sectional studies have been performed on the association between SH and serum lipids. [21][22][23][24] Results from these studies are different. The discrepancy between results may rely on the great heterogeneity of the study population, differences in cutoff value for TSH levels used to define SH, selection criteria and differences of the disease duration.…”

Section: Cumhuriyet Medical Journalmentioning

confidence: 91%

Investigation of the relationship between tsh and serum lipids in patints with subclinical hypothyroidism and euthroid subjects

Doğan¹,

Yılmaz²,

Topçuoğlu³

et al. 2016

Cumhuriyet Med J

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SUMMARYObjective: Although the diagnosis and treatment of subclinical hypothyroidism (SH) primarily depend on the upper normal TSH serum concentration, there are not any well standardized reference limits to be used in the diagnosis and treatment of subclinical hypothyroidism.The aim of the study was to obtain data using serum lipid profile in order to optimize the target TSH levels especially for patients who have a high risk factor for atherosclerosis. Method: A total of 213 patients with the diagnosis of SH and 178 euthyroid subjects were included in the study. Serum lipid parameters and the concentrations of thyrotropin (TSH), and free thyroxin f(T4) and free triiyodotironin f(T3) were recorded. Results: Statistically significant difference was observed between patients and controls in terms of low density lipoprotein cholesterol (LDL-C), total cholesterol (TC), non-HDL-C and the ratio of TC/HDL-C. TSH level correlated significantly with LDL-C, TC, non-HDL-C and the ratio of TC/HDL-C in control and patient groups. According to LDL-C concentrations, different increased risk rate were observed in the presence of different TSH values. Conclusions: We found positive correlation between TSH and atherogenic lipids as expected. Moreover, our findings showed that lower TSH concentrations which are still considered as normal, are also associated with increased lipid values. This might be important especially for patients who have a high risk for atherosclerosis and cardiovascular diseases. Thus, treatment of patients with above upper normal limit of TSH according to risk category might be helpful to reduce the atherogenic process.

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Plasma viscosity as an early cardiovascular risk factor in hirsute women with eumenorrhea or oligomenorrhea

Cited by 20 publications

References 27 publications

Association of dehydroepiandrosterone-sulfate with endothelial function in young women with polycystic ovary syndrome

Association of dehydroepiandrosterone-sulfate with endothelial function in young women with polycystic ovary syndrome

Spectrum of Lipid Abnormality among Thyroid Disorder Patients in Ucms-Th, South Western Region

Investigation of the relationship between tsh and serum lipids in patints with subclinical hypothyroidism and euthroid subjects

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