Plasma vitamin C levels and preterm prelabor rupture of membrane among Egyptian pregnant women

Ibrahim, Zakia M.; Farhan, Rasha Imam; Hussien, Huda A.; Mohamed, Galal L.

doi:10.1097/01.ebx.0000425580.03736.37

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…This study finding was in line with the study conducted in Kambala International University Teaching Hospital in Uganda 7.5% [12], Brazil 3.1% [3], Egypt 5.3% [6], and Nigeria 3.3% [7]. This finding was also higher than the study conducted in India 2.01% [13] and south Kerala India 0.8% 3 Infectious Diseases in Obstetrics and Gynecology [4].…”

Section: Discussionsupporting

confidence: 89%

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Preterm Premature Ruptures of Membrane and Factors Associated among Pregnant Women Admitted in Wolkite Comprehensive Specialized Hospital, Gurage Zone, Southern Ethiopia

Argaw

Mesfin

Tenaw

et al. 2021

Infectious Diseases in Obstetrics and Gynecology

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Introduction. Preterm premature rupture of membrane is the rupture of membrane before 37 weeks of gestational age. It complicates approximately 3 percent of pregnancies and leads to one-third of preterm births. It increases the risk of prematurity and leads to several other perinatal and neonatal complications, including the risk of fetal death. Although the prevalence and associated factors of preterm premature rupture of the membrane were well studied in high-income countries, there is a scarcity of evidence in Ethiopia, particularly in the study area. Method. A hospital-based cross-sectional study design was conducted from 1st June to 30th June 2021 in Wolkite comprehensive specialized hospital. One hundred ninety nine (199) pregnant women were included as study subjects using a systematic random sampling technique. Data were collected using a structured interviewer-administered questionnaire. It carried out descriptive statistical analysis and statistical tests like the odds ratio. Both bivariate and multivariate logistic regression analyses were conducted. Statistically, significant tests were declared at a level of p value < 0.05. Result. The magnitude of preterm premature rupture membrane is 6.6%. Having gestational diabetes mellitus ( AOR = 5.99 (95% CI: 1.01, 32.97) and previous history of abortion ( AOR = 5.31 (95% CI: 1.06, 26.69) were found to be significantly associated with preterm premature rupture of membrane. Conclusion. Having gestational diabetes mellitus and having a previous history of abortion were significantly associated with preterm premature rupture of membrane.

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Section: Discussionsupporting

confidence: 89%

“…The frequency of preterm untimely crack of film influences 3-4.5% of pregnancies with a moderately higher frequency in Africa and Asia. Prove appeared that the size of PPROM accounts in Brazil (3.3%) [3], India (2.2%) [4], China (19.2%) [5], Egypt (3.9%) [6], and Nigeria (3.3%) [7].…”

Section: Introductionmentioning

confidence: 99%

Preterm Premature Ruptures of Membrane and Factors Associated among Pregnant Women Admitted in Wolkite Comprehensive Specialized Hospital, Gurage Zone, Southern Ethiopia

Argaw

Mesfin

Tenaw

et al. 2021

Infectious Diseases in Obstetrics and Gynecology

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“…Prelabour, premature rupture of membrane would better (PPROM) means spontaneous rupture of the fetal membranes before the signs of delivery are evidenced and before the 37 th week of pregnancy. The actual cause of PPROM is unknown [2] , but it has many risk factors some of which are maternal such as previous history of PPROM in a prior pregnancy, direct abdominal trauma, cigarette smoking and others are uteroplacental factors such as uterine anomalies as uterine septum, placental abruption, uterine overdistension as in polyhydramnios and multiple pregnancy, intra-amniotic infection (chorioamnionitis) [3] . The measurement of myometrial thickness may be helpful in the management of pregnant with preterm premature rupture of membranes and threatened preterm labor because it may help in prediction of latency interval of labor [4] .…”

Section: Introductionmentioning

confidence: 99%

Prediction of latency interval of labour in preterm premature rupture of membranes by 2D ultrasound : Case control study

Sokkary

Nassef

Zidan

2020

Evidence Based Women's Health Journal

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Introduction: PPROM occurs in 3% of pregnancies and is responsible for about 30% of preterm births. So, the prediction of latency interval is helpful to the patient and obstetrician to allow possible interventions and proper management. Aim: This study aimed to assess the relation between the myometrial thickness, cervical length, amniotic fluid index and membrane thickness (measured by transabdominal ultrasound) and latency interval of labor in cases of preterm premature rupture of membranes (PPROM). Patients and Methods:This was a case control study that was conducted at Al-zahraa University Hospital and Shebin El-Kom Teaching Hospital. One hundred pregnant women (28-34 weeks gestation) were divided into two groups: The first group (fifty cases of PPROM) and the second group (control group = fifty cases with no PPROM), they were subjected to routine transabdominal ultrasound examination to assess fetal biometry, amniotic fluid index, thickness of fetal membranes, cervical length, and the myometrial thickness in 4 areas (the lower uterine segment, mid-anterior uterine wall, uterine fundus, and posterior uterine wall). Results: The myometrial thickness of the anterior wall and LUS was significantly thinner, cervical length showed significant shortening, AFI was significantly decreased and the membrane thickness was significantly thicker in PPROM cases than in controls. The latency interval showed a significant inverse correlation with gestational age and a significant direct correlation with myometrial thickness, cervical length and AFI. Conclusion: There was a significant thinning in the anterior and LUS myometrial thickness in addition to shortening of cervical length, decrease in amniotic fluid index and increase in membrane thickness. Also, the myometrial thickness, the cervical length and the AFI were directly correlated with latency interval.

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Vitamin C Levels in Pregnant Women and the Efficacy of Vitamin C Supplements in Preventing Premature Rupture of Membranes: A Systematic Review and Meta-Analysis

Pejcic,

Petrovic,

Djordjic

et al. 2024

Balkan Med J

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Background Premature rupture of membranes (PROM) is defined as the leakage of amniotic fluid before the onset of labor and delivery contractions. Some studies found that women who experienced PROM had significantly lower vitamin C blood levels than those who did not, while others found no significant differences. Previous systematic reviews and meta-analyses on the efficacy of vitamin C in the prevention of PROM had conflicting results. Aims Conduct a systematic review and meta-analysis to determine if there was a significant difference in vitamin C blood levels in women who had PROM versus the control group who did not and to determine if vitamin C supplements could help prevent it. Study Design Systematic review and meta-analysis. Methods We registered our protocol with PROSPERO (CRD42022371644). We searched PubMed/MEDLINE, Web of Science, and Scopus through February 15, 2024. Additionally, backward and forward citation searches were conducted. Studies were selected based on predetermined inclusion and exclusion criteria. Meta-Essentials: Workbooks for Meta-Analysis (version 1.5) was used for analysis. Results Twenty-five studies (26 reports) met all eligibility criteria, with 18 studies (18 reports) assessing vitamin C levels and seven studies (eight reports) evaluating efficacy. Women with PROM, whether preterm or term, had significantly lower vitamin C levels [Hedges’ g, -1.48; 95% confidence interval (CI): -2.82, -0.14; p = 0.020; I 2 = 94.08%) and specifically preterm PROM after removing the outlying study [Hedges’ g, -1.29; 95% CI: -1.85, -0.73; p < 0.001; I 2 = 87.35%). Vitamin C supplementation significantly reduced the risk of preterm or term PROM [risk ratio (RR), 0.57; 95% CI: 0.39, 0.81; p < 0.001; I 2 = 12.17%), particularly for preterm PROM (RR, 0.67; 95% CI: 0.45, 0.99; p = 0.001; I 2 = 0.00%). There were no significant differences in vitamin C levels between women with term PROM and controls, and there were no differences in the risk of developing term PROM between women taking vitamin C supplements and controls. Results were not robust in all sensitivity analyses. Conclusion Women with PROM, particularly those who developed it preterm, appear to have significantly lower vitamin C levels, and vitamin C supplementation appears to be effective in reducing the risk of PROM, particularly preterm PROM. More high-quality studies with low risk of bias, more homogenous, and larger samples are needed to confirm these findings.

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Plasma vitamin C levels and preterm prelabor rupture of membrane among Egyptian pregnant women

Cited by 3 publications

References 19 publications

Preterm Premature Ruptures of Membrane and Factors Associated among Pregnant Women Admitted in Wolkite Comprehensive Specialized Hospital, Gurage Zone, Southern Ethiopia

Preterm Premature Ruptures of Membrane and Factors Associated among Pregnant Women Admitted in Wolkite Comprehensive Specialized Hospital, Gurage Zone, Southern Ethiopia

Prediction of latency interval of labour in preterm premature rupture of membranes by 2D ultrasound : Case control study

Vitamin C Levels in Pregnant Women and the Efficacy of Vitamin C Supplements in Preventing Premature Rupture of Membranes: A Systematic Review and Meta-Analysis

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