Plasma vitamin E and A changes during cardiopulmonary bypass and in the postoperative course

Abstract

Background: Cardiopulmonary bypass induces a generalized inflammatory reaction accompanied by free radical generation. Depletion of antioxidants could result and is reported for vitamin E and C. We investigated the effect of cardiopulmonary bypass on plasma concentrations of α-tocopherol, retinol, and biochemical variables (e.g., triacylglycerol, cholesterol, and C-reactive protein). Patients and methods: Plasma levels of all parameters were investigated by serial sampling in ten men undergoing elective coronary artery bypass grafting. Samples were taken before, during, and up to 48 h after bypass to obtain time profiles of the laboratory indices. Results: α-Tocopherol and retinol decreased during cardiopulmonary bypass when not adjusted for confounders. After adjustment for hemodilution and lipids, no significant change was noted during bypass.However, a reduction in retinol was observed 48 h postoperatively. Conclusions: These data indicate that vitamin E and A analysis to ascertain links to their consumption via the production of free radicals under conditions of cardiopulmonary bypass may be inappropriate. Specifically, during bypass a reduction in systemic vitamin E and A seems to be a response to changes in blood volume and liver function.

Flupenthixol and cefotiam: effects on vitamin A metabolism in rats

“…One proposed mechanism underlying the immediate drop of plasma vitamin A after initiation of treatment is an impaired synthesis and/or secretion of carrier protein (i.e. retinol-binding protein, a negative acute-phase reactant protein; Schindler et al 2003) from the liver. In view of the short exposure time, it is probable that the experimental drugs reach the liver at a low concentration, which is, however, sufficiently high to exert the retinollowering effect found.…”

Oxidative Stress and Methods for Its Correction in Patients with Acute Coronary Circulatory Disorders During Perioperative Direct Myocardial Revascularization

“…В контрольной группе содержание ТФ сущест венно не отличалось от предыдущих этапов. Повышение уровня эндогенного АО, возможно, происходило ком пенсаторно в ответ на активизацию процессов ПОЛ [24]. В итоге коэффициент окислительного стресса К в основной группе уменьшился статистически достоверно по отношению к III этапу на 35% (p<0,05) и на 47% (p<0,01), в сравнении с начальным его значением.…”