Plasma Volume Expansion in Early Pregnancy

Bernstein, Ira M.; Ziegler, William F.; Badger, Gary J.

doi:10.1097/00006250-200105000-00005

Cited by 68 publications

(83 citation statements)

References 10 publications

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“…These changes begin early in pregnancy, reach their peak during the second trimester and then remain relatively constant until delivery. 37,38 In uncomplicated pregnancy, plasma renin activity tends to be increased and atrial natriuretic peptide levels are slightly reduced. 39,40 In contrast, plasma atrial natriuretic peptide concentrations have been extensively reported as increased in patients with hypertensive disorders during pregnancy, especially in patients with severe preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

Additive value of standard ECG for the risk prediction of hypertensive disorders during pregnancy

Angeli

Verdecchia²,

Narducci

et al. 2011

Hypertens Res

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Prediction of hypertensive complications during pregnancy remains limited, especially in healthy and initially normotensive women. We conducted a prospective screening study for hypertensive complications in pregnant women. We studied 221 nulliparous healthy and normotensive women with singleton pregnancies whose first routine visit was carried out before the twelfth week of gestation. We tested several demographic, clinical and laboratory variables as predictors of a composite pool of prespecified events, including gestational hypertension, preeclampsia or eclampsia. We analyzed the potential additive role of ECG in the identification of women at increased risk of hypertensive disorders. Mean age at entry was 30 years. During pregnancy, there were 28 prespecified events (22 women with gestational hypertension, 5 with preeclampsia and 1 with eclampsia). In univariate analyses, blood pressure (BP), weight, body mass index (BMI) and left atrial (LA) abnormality detected by ECG in lead V 1 showed an association with the risk of hypertensive disorders (all Po0.05). In a multivariable analysis, only mean BP (OR: 3.08, 95% confidence interval (CI): 1.61-5.92; P¼0.001 for each 10 mm Hg increase) and LA abnormality in lead V 1 (OR: 4.35, 95% CI: 1.84-10.31; P¼0.001) were independent predictors of hypertensive disorders. The final model discriminated well between women who developed hypertensive disorders and women who remained normotensive (AUC¼0.75; 95% CI: 0.67-0.84; Po0.0001). This study suggests that standard ECG is valuable to refine risk stratification for hypertensive disorders in initially normotensive pregnant women. LA abnormality, easily detected by simple visual inspection of the traditional ECG, and mean arterial pressure (MAP), allows a rapid and effective risk stratification for hypertensive disorders.

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Section: Discussionmentioning

confidence: 99%

Additive value of standard ECG for the risk prediction of hypertensive disorders during pregnancy

Angeli

Verdecchia²,

Narducci

et al. 2011

Hypertens Res

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“…Increase in blood volume is, therefore, more marked in multiple pregnancies and in iron deficient states. Expansion of plasma volume occurs by 10-15 % at 6-12 weeks of gestation [2,3]. During pregnancy, plasma renin activity tends to increase and atrial natriuretic peptide levels tend to reduce, though slightly.…”

mentioning

confidence: 99%

Physiological Changes in Hematological Parameters During Pregnancy

Chandra

Tripathi

Mishra

et al. 2012

Indian J Hematol Blood Transfus

263

221

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“…There occurs 10-15% of plasma volume expansion by 6-12 weeks of gestation. [15,16] During pregnancy, there is increase in plasma renin activity and atrial natriuretic peptide levels slightly reduce. This suggests that, the elevation in plasma volume during pregnant state, is in response to an underfilled vascular system resulting from systemic vasodilatation and increase in vascular capacitance, rather than actual blood volume expansion, which would produce the opposite hormonal profile instead (i.e., low plasma renin and elevated atrial natriuretic peptide levels).…”

Section: Discussionmentioning

confidence: 99%

“…[24,25] In the first trimester of pregnancy, there is an absolute monocytosis but decreases as gestation advances. Monocytes by infiltrating the decidual tissue (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) th week of gestation) possibly, through PGE 2 -mediated immunosuppression help in preventing fetal allograft rejection. [26] In pregnancy, monocyte to lymphocyte ratio is markedly increased.…”

Section: Discussionmentioning

confidence: 99%

Variation in erythrocyte and leukocyte counts before and after normal vaginal delivery

Sneha¹,

M²,

Lepakshi³

2017

Natl J Physiol Pharm Pharmacol

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Background: A woman's reproductive period begins at menarche and ends in menopause. It usually extends from 13 to 45 years. Many physiological and hematological changes do occur during the pregnancy period and after delivery. Aims and Objectives: The present study was done to evaluate the variations in red blood cell (RBC) and white blood cell (WBC) counts before and after normal vaginal delivery. Materials and Methods: A hospital-based cohort study conducted on 500 pregnant females who got admitted to labor room for delivery at McGann Teaching District Hospital, Shivamogga. Blood samples were taken during the time of their admission to labor ward and within 12-24 h after normal vaginal delivery and the cell counts were estimated using Sysmex KX-21 automated hematology analyzer. Results: The mean values of RBC count before delivery were found to be 4.4 millions/mm 3 with standard deviation of ±0.5 which dropped to 4 millions/mm 3 with standard deviation of ±0.5 on the 1 st day of puerperium. The mean values of WBC count before delivery were found to be 12,495.6 cells/mm 3 with standard deviation of ±3663.5 cells/mm 3 which increased to 16,027 cells/mm

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Plasma Volume Expansion in Early Pregnancy

Cited by 68 publications

References 10 publications

Additive value of standard ECG for the risk prediction of hypertensive disorders during pregnancy

Additive value of standard ECG for the risk prediction of hypertensive disorders during pregnancy

Physiological Changes in Hematological Parameters During Pregnancy

Variation in erythrocyte and leukocyte counts before and after normal vaginal delivery

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