Plasmablastic lymphoma clinically presenting in the urinary tract

Tille, Jean-Christophe; Pelte, Marie‐Françoise; Schwartz, Julien Vincent G. A.; Dietrich, Pierre‐Yves; Mckee, Thomas Alexander

doi:10.1016/j.anndiagpath.2011.02.002

Cited by 13 publications

(12 citation statements)

References 11 publications

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“…[ 2 ] However, PBL originating from the urinary tract is extremely rare, and to date, there have been only two reported cases of ureteral PBL: one with a multifocal bladder tumor and another with a paraurethral mass. [ 3 ] To our knowledge, this is the first report of a case with PBL presented as a polypoid lesion of the ureteropelvic junction, clinically mimicking as usual type urothelial carcinoma, and resected by laparoscopic nephroureterectomy.…”

Section: Discussionmentioning

confidence: 99%

“…As shown in the present case, EBER can be detected using an in situ hybridization technique in the PBL cells in 80% of HIV-positive and 46% of HIV-negative patients. [ 3 ] Rearrangement of the MYC gene at 8q24 can be detected in approximately half of PBL cases, with the immunoglobulin genes acting as the most frequent translocation partners. [ 5 ] In addition to MYC rearrangements, gains of MYC are also occasionally seen in PBL.…”

Section: Discussionmentioning

confidence: 99%

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Plasmablastic lymphoma presenting as a ureteral polypoid mass

2018

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Plasmablastic lymphoma (PBL) is a rare and aggressive subtype of B-cell lymphoma, which occurs typically in the oral cavity of human immunodeficiency virus (HIV)-positive patients. We report a case of a 44-year-old HIV-positive patient with a solitary polypoid mass of the left ureteropelvic junction, causing unilateral hydronephrosis and clinically mimicking urothelial carcinoma. A laparoscopic nephroureterectomy was performed, and pathological examinations revealed the mass as PBL. PBL can present in various forms, even as a polypoid mass of the upper urinary tract, and it should be considered in the differential diagnosis of any mass detected in the HIV-positive patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Plasmablastic lymphoma presenting as a ureteral polypoid mass

2018

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“…A few cases of CNS involvement have also been reported [33,35]. The 2 cases reported by Tille et al [18 ]are possibly the only cases of EoPL in the urinary tract. One of the cases reported by Chapman-Fredricks et al [24] also showed the intravascular component of EoPL, which the authors felt could be related to tumor aggressiveness.…”

Section: Discussion and Review Of The Literaturementioning

confidence: 92%

“…The differential diagnoses that are most commonly considered include: undifferentiated carcinoma, immunoblastic DLBCL, Burkitt's lymphoma, ALK+ DLBCL and anaplastic plasmacytoma [17,18,19]. The closest differential among these is anaplastic plasmacytoma, which, however, does not show a consistent blastic morphology or high Mib-1 labeling index.…”

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

Extraoral Plasmablastic Lymphoma Detected Using Ascitic Fluid Cytology and Flow Cytometry: A Case Report with a Review of the Literature

Dorwal

Sachdev²,

Mishra³

et al. 2014

Acta Cytologica

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Background: Plasmablastic lymphoma (PL) is a relatively new category of lymphoma, which has been considered to be found predominantly in the oral cavity and has a strong association with HIV. Case: We report a case of extraoral/mesenteric PL detected using cytological examination of ascitic fluid assisted by flow cytometric (FC) analysis. The cells were positive for CD38, CD138, CD10, CD45 and CD56 and negative for CD3, CD19, CD20 and CD79a, with cytoplasmic lambda light-chain restriction. We also reviewed 67 cases of extraoral PL from the available literature and found them to be less often associated with HIV (than oral PL), occurring mostly in males aged 30-60 years, with the most common extraoral site being the anorectal region. Conclusion: A high index of suspicion at the level of the cytopathologist is imperative for identifying lymphoma cells in a body fluid. A rare entity like PL can also be diagnosed on cytology assisted by ancillary techniques (like FC), without the need for a biopsy. We also suggest that the minimum panel to diagnose PLs should include CD138, MUM-1, Ki-67, ALK-1, CD3, immunoglobulin light-chains, CD20 and PAX5.

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“…Recently, increasing cases have been reported in HIV-negative patients [ 1 - 5 ]. Extraoral sites, such as the central nervous system, maxillary sinus, nasal cavity, gastrointestinal tract, liver, and retroperitoneal region, can also be involved [ 1 - 4 , 6 - 9 ]. Many differences on the aspect of the clinicopathologic features and treatment response between HIV-positive and -negative cases have been revealed [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Human immunodeficiency virus-negative plasmablastic lymphoma in the neck: a rare case report and literature review

Jiang

Liu

et al. 2014

Eur J Med Res

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Plasmablastic lymphoma (PBL) is an aggressive neoplasm exclusively occurring in AIDS patients. Recently, increasing cases of human immunodeficiency virus (HIV)-negative PBL have been reported. No standard therapy protocol is currently available since there is a great difference between PBL with and without HIV infection. Here, we present a rather rare case of HIV-negative PBL in the neck that dramatically responded to radiotherapy alone. Our case highlights the possibility of PBL in the neck and helps to expand our understanding of this separate lymphoma. The related literature review summarized the clinicopathological features and treatment status of HIV-negative PBL.

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Plasmablastic lymphoma clinically presenting in the urinary tract

Cited by 13 publications

References 11 publications

Plasmablastic lymphoma presenting as a ureteral polypoid mass

Plasmablastic lymphoma presenting as a ureteral polypoid mass

Extraoral Plasmablastic Lymphoma Detected Using Ascitic Fluid Cytology and Flow Cytometry: A Case Report with a Review of the Literature

Human immunodeficiency virus-negative plasmablastic lymphoma in the neck: a rare case report and literature review

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