Plasmacytoid dendritic cells: from specific surface markers to specific cellular functions

Dzionek, Andrzej; Inagaki, Yoshimasa; Okawa, Katsuya; Nagafune, Jun; Röck, Jürgen; Sohma, Yoshiaki; Winkels, Gregor; Zysk, Monika; Yamaguchi, Yasunori; Schmitz, Jürgen

doi:10.1016/s0198-8859(02)00752-8

Cited by 190 publications

(172 citation statements)

References 69 publications

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“…2B). Our data on tonsil samples are concordant with the previous data from Dzionek et al [14] [16]. A tolerogenic cytokine milieu might therefore increase the amount of regulatory phenotype Nrp-1 1 T cells and this could be an explanation for our heterogeneous and apparently diverging results.…”

Section: Nrp-1-expressing T Cells In Secondary Lymphoid Organssupporting

confidence: 92%

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Neuropilin‐1 is not a marker of human Foxp3⁺ Treg

et al. 2009

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Treg are immune cells that play a critical role in the regulation of the immune response. Although the transcription factor Foxp3 is widely accepted as the standard marker of Treg, specific surface markers are needed to better characterize these cells and decipher their mechanisms of action. Neuropilin-1 (Nrp-1), a membrane protein primarily involved in the nervous system, was identified as a specific marker of murine Treg, but its expression has not been rigorously investigated in human Treg. Here we show that in contrast to murine Treg and regardless of their origins (blood, thymus, spleen, lymph node or tonsil), human Foxp3 1 Treg do not specifically express Nrp-1. However, a population of Foxp3 À Nrp-1 1 T cells can be detected in human secondary lymphoid organs, and Nrp-1 expression is induced on peripheral blood T lymphocytes upon in vitro activation. We conclude that Nrp-1 cannot be used as a specific marker of human Treg, but might represent a novel activation marker of human T cells both in vitro and in vivo.

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Section: Nrp-1-expressing T Cells In Secondary Lymphoid Organssupporting

confidence: 92%

“…Since two previous reports had identified Nrp-1-expressing T cells in human tonsils [14] and lymph nodes [15], we further analyzed our data focusing on such subsets. Nrp-1-expressing T cells were variably abundant in secondary lymphoid organs, but consistently rare in peripheral blood ( Fig.…”

Section: Nrp-1-expressing T Cells In Secondary Lymphoid Organsmentioning

confidence: 99%

Neuropilin‐1 is not a marker of human Foxp3⁺ Treg

et al. 2009

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“…In non-neoplastic plasmacytoid dendritic cells, BDCA-2 is regulated as a maturation marker, with increased expression as plasmacytoid dendritic cell precursors mature and differentiate in the bone marrow and blood. Flow cytometric analysis of bone marrow by Dzionek et al 34 argues that cell surface BDCA-2 increases incrementally as plasmacytoid dendritic cells differentiate from CD34 þ precursors. Thus, the BDCA-2-positive subset of CD4 þ CD56 þ hematodermic neoplasms may represent a tumor recapitulating a more mature plasmacytoid dendritic cell stage and conversely, the TdT þ subset may represent a less mature, precursor plasmacytoid dendritic cell leukemia/lymphoma.…”

Section: Discussionmentioning

confidence: 99%

Expression of the plasmacytoid dendritic cell marker BDCA-2 supports a spectrum of maturation among CD4+ CD56+ hematodermic neoplasms

et al. 2006

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“…Las subpoblaciones de células dendríticas circulantes pueden ser identificadas también mediante un panel de anticuerpos monoclonales: BDCA-1 (CD1c), expresado específicamente en las cDC, y el BDCA-2 (una lectina II de tipo C), expresada específicamente en las pDC (14). En sangre, los porcentajes de estas dos poblaciones celulares son muy bajos, aproximadamente, 0,22 % y 0,05 % de las células mononucleares, respectivamente (15).…”

Section: Biología De Las Células Dendríticasunclassified

Papel de las células dendríticas tolerogénicas ILT3+/ILT4+ en la respuesta inmunitaria a trasplante de órganos y tejidos

Arboleda¹,

García²,

Álvarez³

2011

biomedica

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Las células dendríticas son las células presentadores de antígeno más potentes y, por lo tanto, son importantes en el desencadenamiento de la respuesta inmunitaria frente a aloantígenos; sin embargo, también juegan un papel fundamental en el mantenimiento de la tolerancia periférica. La tolerancia es potenciada por la expresión en estas células de los receptores inhibidores ILT3 e ILT4, los cuales, mediante el reclutamiento de fosfatasas de tirosinas a sus dominios ITIM, inhiben la activación de la célula presentadora de antígeno y conducen a una débil respuesta de la célula T. Estos receptores propician, además, una interacción bidireccional con células T supresoras, T reguladoras o ambas, generando una cascada inmunorreguladora específica de antígeno, en la cual la célula dendrítica se comporta como una célula "tolerogénica". En esta revisión analizamos la biología y el comportamiento de las células dendríticas tolerogénicas que expresan altos niveles de ILT3 e ILT4, así como algunos aspectos moleculares y genéticos de estos receptores y su importancia en la modulación de las respuestas inmunitarias específicas de aloantígeno frente a un trasplante.Palabras clave: trasplante, células dendríticas, tolerancia inmunológica, inmunomodulación, supervivencia. ILT3 + /ILT4 + tolerogenic dendritic cells and their influence on allograft survivalDendritic cells, the most powerful antigen-presenting cells, are important for triggering of the immune responses to allo-antigens. However, they also play a fundamental role in the peripheral tolerance maintenance. Tolerance is enhanced by the presence on the dendritic cell surface of the inhibitor receptors ILT3 and ILT4. They recruit protein tyrosine-phosphatases to their ITIM domains and inhibit antigen-presenting cell activation, leading T cell hypo-responsivensess. Moreover, these receptors favor a bidirectional interaction with T-suppressor and T-regulator cells, generating an antigen-specific immunoregulator cascade, in which the dendritic cell behaves as a tolerogenic cell. In the current review, analysis is centered on the biology and behavior of the tolerogenic dendritic cells that express high levels of ILT3 and ILT4. Some molecular and genetics aspects of these receptors are discussed as well as their importance in the modulation of the allo-specific antigen immune response to transplants.

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Plasmacytoid dendritic cells: from specific surface markers to specific cellular functions

Cited by 190 publications

References 69 publications

Neuropilin‐1 is not a marker of human Foxp3⁺ Treg

Neuropilin‐1 is not a marker of human Foxp3⁺ Treg

Expression of the plasmacytoid dendritic cell marker BDCA-2 supports a spectrum of maturation among CD4+ CD56+ hematodermic neoplasms

Papel de las células dendríticas tolerogénicas ILT3+/ILT4+ en la respuesta inmunitaria a trasplante de órganos y tejidos

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Plasmacytoid dendritic cells: from specific surface markers to specific cellular functions

Cited by 190 publications

References 69 publications

Neuropilin‐1 is not a marker of human Foxp3+ Treg

Neuropilin‐1 is not a marker of human Foxp3+ Treg

Expression of the plasmacytoid dendritic cell marker BDCA-2 supports a spectrum of maturation among CD4+ CD56+ hematodermic neoplasms

Papel de las células dendríticas tolerogénicas ILT3+/ILT4+ en la respuesta inmunitaria a trasplante de órganos y tejidos

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Neuropilin‐1 is not a marker of human Foxp3⁺ Treg

Neuropilin‐1 is not a marker of human Foxp3⁺ Treg