Plasmalogens: biosynthesis and functions

Nagan, Narasimhan; Zoeller, Raphael A.

doi:10.1016/s0163-7827(01)00003-0

Cited by 559 publications

(577 citation statements)

References 184 publications

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“…The vinyl ether bond is readily susceptible to breakdown under acidic [19,20] and oxidative conditions [7,14,21]. Since PFB hydroxylamine derivatization requires acidic conditions we tested the stability of the vinyl ether bond, the acyl ester and the amide bond under derivatization conditions.…”

Section: Resultsmentioning

confidence: 99%

Quantification of Pentafluorobenzyl Oxime Derivatives of Long Chain Aldehydes by GC–MS Analysis

Brahmbhatt

Nold

Albert

et al. 2008

Lipids

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Negative ion mass spectrometric techniques for compounds having good ionization properties, such as pentafluorobenzyl derivatives, are believed to be more sensitive than positive ion methods. In this study we develop a technique of quantification of long-chain aldehydes by analysis of their pentafluorobenzyl oxime derivatives utilizing gas chromatography-mass spectrometry in the negative ion chemical ionization mode. We establish that separation of plasmalogens prior to pentafluorobenzyl derivatization is essential and achieve this separation over a silica column. We further demonstrate the sensitivity of this method and utilize this technique to identify increases in hexadecanal and octadecanal in 3-aminotriazole treated human neutrophils.

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Section: Resultsmentioning

confidence: 99%

Quantification of Pentafluorobenzyl Oxime Derivatives of Long Chain Aldehydes by GC–MS Analysis

Brahmbhatt

Nold

Albert

et al. 2008

Lipids

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“…At this moment, we can only speculate about the mechanisms behind these findings. However, the antioxidant properties of plasmalogens [23] could explain the predictive value of C18 plasmalogens as forecast of freezability, a hypothesis supported by the negative correlation of this specific plasmalogen with LPO post thaw.…”

Section: Discussionmentioning

confidence: 99%

Fatty acids and plasmalogens of the phospholipids of the sperm membranes and their relation with the post-thaw quality of stallion spermatozoa

et al. 2011

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Fatty acids and plasmalogens of the phospholipids of the sperm membranes and their relation with the post-thaw quality of stallion spermatozoa, 2011, THERIOGENOLOGY, (75) AbstractFatty acids and plasmalogens were extracted from the phospholipids of the plasma membrane of stallion spermatozoa, to determine their relation with sperm quality after freezing and thawing. Sperm quality was rated using a quality index that combined the results of the analysis of sperm motility and velocity (CASA analysis), membrane status and mitochondrial membrane potential (flow cytometry) post thaw. Receiving operating system (ROC) curves were used to evaluate the value of specific lipid components of the sperm membrane herein studied as forecast of potential freezeability. From all parameters studied the ratio of percentage of C16 plasmalogens related to total phospholipids was the one with the better diagnostic value. For potentially bad freezers, the significant area under the ROC-curve was 0.74, with 75% sensitivity and 79.9% specificity for a cut off value of 26.9. Also the percentage of plasmalogens respect to total phospholipids gave good diagnostic value for bad freezers. On the other hand, the percentage of C18 fatty aldehydes related to total phospholipids of the sperm membrane properly forecasted freezeability with an area under the ROC curve of 0.70 with 70% sensitivity and 62.5% specificity for a cut off value of 0.32.

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“…178-179). For a complete review of the structures, biosynthesis and physiological functions of plasmalogens, see Nagan and Zoeller (2001). The glycerol ethers have many biological activities, in particular concerning cancer; a whole issue of the journal Lipids was devoted to these problems (Baumann, 1986; see also Berdel and Okamoto, 1990;Kovar, Grauer, and Zimmermann, 1994).…”

Section: Membrane Lipidsmentioning

confidence: 99%

Archaea

Kornprobst

2014

Encyclopedia of Marine Natural Products

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The article contains sections titled: General Introduction Membrane Lipids Macrocyclic Dialkyl Glycerol Diethers Paleotemperatures Index: TEX 86 and BIT Index Pranylquinones Cyclic Polysulfides Bacteriorhodopsin of Halophiles Extremozymes

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Plasmalogens: biosynthesis and functions

Cited by 559 publications

References 184 publications

Quantification of Pentafluorobenzyl Oxime Derivatives of Long Chain Aldehydes by GC–MS Analysis

Quantification of Pentafluorobenzyl Oxime Derivatives of Long Chain Aldehydes by GC–MS Analysis

Fatty acids and plasmalogens of the phospholipids of the sperm membranes and their relation with the post-thaw quality of stallion spermatozoa

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