1986
DOI: 10.1093/infdis/153.2.261
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Plasmid-Mediated Resistance to Multiple Antibiotics in Salmonella typhi

Abstract: Two hundred forty-one strains of Salmonella typhii isolated in Lima, Peru, from October 1981 through February 1983 were tested for susceptibility to antimicrobial agents. Seventy-two strains (29.9%) were resistant to chloramphenicol and other antibiotics, including ampicillin, sulfonamides, and trimethoprim. The minimal inhibitory concentrations of 17 antimicrobial agents were determined for all of these chloramphenicol-resistant strains. Sch 25393, new beta-lactams, new quinolones, and the formulation clavula… Show more

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Cited by 80 publications
(43 citation statements)
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“…Our results confirm earlier findings by Jesudasam and John (1992) and Sudarshan et al (1992) that autotransferring plasmids mediate multidrug resistance in S. typhi, and that such plasmids transfer resistance to all four antibiotics (ACTCo). In the present study no attempt was made to mobilize non-transferable drug resistance, though it is known that the ability to mobilize resistance is also an indication of the presence of plasmid-mediated resistance, albeit non-conjugative.…”
Section: Discussionsupporting
confidence: 93%
“…Our results confirm earlier findings by Jesudasam and John (1992) and Sudarshan et al (1992) that autotransferring plasmids mediate multidrug resistance in S. typhi, and that such plasmids transfer resistance to all four antibiotics (ACTCo). In the present study no attempt was made to mobilize non-transferable drug resistance, though it is known that the ability to mobilize resistance is also an indication of the presence of plasmid-mediated resistance, albeit non-conjugative.…”
Section: Discussionsupporting
confidence: 93%
“…An extensive epidemic of typhoid fever in Mexico with over 10000 cases was due to multi-drug resistant strains of Salmonella typhi [6]. Similar multiresistant strains of S. typhi have also been reported from other countries [7][8][9]. Vibrio cholerae resistant to commonly used antibiotics have been reported from Philippines [10], Thailand [ 11], Tanzania [12] and Kenya [13].…”
Section: Introductionmentioning
confidence: 87%
“…Salmonella typhi resistant to chloramphenicol (C), ampicillin (A) and trimethoprim-sulphamethoxazole (TMP-SMZ) became prevalent in some Asian countries during the late 1980s and early 1990s [1][2][3][4]. It is generally believed that this multidrug resistant (MDR) variety emerged in southern China [2] and then spread to the neighbouring countries.…”
mentioning
confidence: 99%