Plasminogen and cell migration in vivo

Plasminogen Is an Important Regulator in the Pathogenesis of a Murine Model of Asthma

“…T cells are key to the initiation of the response (reviewed in Reference 1); and eosinophils induce many of the pathological changes in the lungs (18) and correlate with disease severity (28). Because plasminogen plays a key role in inflammatory cell migration (8,9,29), we compared the response of Plg ϩ/ϩ and Plg Ϫ/Ϫ mice in a widely used OVA challenge model to induce allergic pulmonary inflammation. Our major findings are as follows:…”

“…Studies conducted in plasminogen (Plg)-deficient mice have demonstrated significant suppression of inflammatory cell recruitment in response to a variety of experimental stimuli (8,9). In another study, marked alteration in inflammatory cell recruitment into the lungs of Plg Ϫ/Ϫ mice suppressed the development of tissue damage in a model of lung injury (10).…”

Host–Pathogen Interactions in Tuberculosis

“…Since similar mechanisms are typical for tumor cell migration and invasion (Mignatti & Rifkin, 1993) where Plm directly degrades laminin, a major glycoprotein of basement and indirectly damages tissue barriers by activating MMPs, the term "bacterial metastasis" is now used in analogy to tumor cells metastasis (Plow et al, 1999;Läteenmäki et al, 2000Läteenmäki et al, , 2005.…”

In vivo regulation of plasminogen function by plasma carboxypeptidase B

“…In addition to its role in fibrinolysis, Plg facilitates cell migration (reviewed in ref. 18). A manifestation of this function is the suppression of monocyte/macrophage recruitment in Plg -/-mice in response to the intraperitoneal administration of the inflammatory stimulus, thioglycollate (17).…”

“…The specificity of pCPB for basic amino acids has a particularly important impact upon the functions of Plg. As verified from the characterization of the Plgdeficient mouse, Plg has a broad physiological and pathophysiological role; it is essential for efficient fibrinolysis (13)(14)(15) and facilitates cell migration (16)(17)(18)(19). These activities depend upon the capacity of Plg to bind fibrin and cell surfaces via its lysine binding sites (LBS) (20)(21)(22)(23)(24)(25)(26).…”