Plasmocytic Mucosal Infiltrates in Multiple Myeloma

Lightstone, Alan C.; Cohen, Harvey J.

doi:10.1001/archderm.1960.01580060075010

Cited by 7 publications

(1 citation statement)

References 2 publications

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“…Although the first case of o-PCM was reported in the literature in 1960 [ 10 ], most of the cases were published after 2000 (22 papers before 2000 vs. 70 papers after 2000). This increase could be due both to greater attention by clinicians and patients to alterations of the oral mucosa and to an increase in exogenous stimuli to which the oral cavity is exposed with greater antigenic complexity.…”

Section: Discussionmentioning

confidence: 99%

Pitfalls and Challenges in Oral Plasma Cell Mucositis: A Systematic Review

Coppola

Cantile

Canfora

et al. 2022

JCM

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Plasma cell mucositis (PCM) is an unusual idiopathic disorder characterized by dense infiltrates of plasma cells in submucosa. Clinical phenotypes of oral plasma cell mucositis (o-PMC) are heterogenous. A systematic review has been conducted, aiming to synthesize the available evidence on o-PCM. Literature search, study design, and data analysis were performed following PRISMA guidelines. The SPIDER and the PICO tools were used to structure the research question. In all, 79 case reports and 19 case series on a total of 158 patients (85 females and 73 males; average age: 44.1 years) were identified. Among oral sites involved, gingiva (65.82%) was the most frequent site. The main clinical phenotype was erythema (99.37%). In relation to symptoms, pain (60.76%) was the most reported. On histological examination, all samples showed a dense inflammatory infiltration with predominant plasma cells. The treatment regimens of o-PCM were summarized in six groups: irritant removal; topical/systemic corticosteroids; topical/systemic immunosuppressants/immunomodulators; surgery and similar treatments; radiotherapy and chemotherapy; other therapies, such as antifungals, antibiotics, and antivirals drugs. This is the first systematic review aimed to synthesize the findings of studies on o-PCM. The lack of universally shared information on etiological factors and the absence of international consensus of pharmacological protocols make o-PCM a diagnostic and therapeutic challenge.

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Section: Discussionmentioning

confidence: 99%