Plasmodium vivax

Anstey, Nicholas M.; Douglas, Nicholas M.; Poespoprodjo, Jeanne Rini; Price, Ric N.

doi:10.1016/b978-0-12-397900-1.00003-7

Cited by 184 publications

(154 citation statements)

References 239 publications

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“…Despite the large burden of disease, P. vivax has traditionally been neglected because it has been considered a relatively benign form of malaria. Now it is recognized that P. vivax can cause severe disease (similar to that of Plasmodium falciparum ) [2] and, together with increased recognition of the burden, there are renewed efforts in the development of P. vivax -specific interventions (that is, vaccines) and surveillance tools (diagnostics, serosurveillance) to expedite the goal of malaria elimination and eradication [3,4]. …”

Section: Introductionmentioning

confidence: 99%

Immunological markers of Plasmodium vivaxexposure and immunity: a systematic review and meta-analysis

Cutts

Powell

Agius

et al. 2014

BMC Med

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BackgroundIdentifying Plasmodium vivax antigen-specific antibodies associated with P. vivax infection and protective immunity is key to the development of serosurveillance tools and vaccines for malaria. Antibody targets of P. vivax can be identified by seroepidemiological studies of individuals living in P. vivax-endemic areas, and is an important strategy given the limited ability to culture P. vivax in vitro. There have been numerous studies investigating the association between P. vivax antibody responses and P. vivax infection, but there has been no standardization of results to enable comparisons across populations.MethodsWe performed a systematic review with meta-analysis of population-based, cross-sectional, case–control, and cohort studies of individuals living in P. vivax-endemic areas. We searched 6 databases and identified 18 studies that met predefined inclusion and quality criteria, and examined the association between antibody responses to P. vivax antigens and P. vivax malaria.ResultsThe majority of studies were published in South America (all from Brazil) and the rest from geographically diverse areas in the Asia-Pacific region. Considerable heterogeneity in estimates was observed, but IgG responses to PvCSP, PvMSP-119, PvMSP-9RIRII, and PvAMA1 were associated with increased odds of P. vivax infection in geographically diverse populations. Potential sources of heterogeneity included study design, different transmission intensities and transmigrant populations. Protective associations were observed for antibodies to PvMSP-119, PvMSP-1NT, PvMSP-3α and PvMSP-9NT antigens, but only in single geographical locations.ConclusionsThis systematic review revealed several antigen-specific antibodies that were associated with active infection and protective immunity, which may be useful biomarkers. However, more studies are needed on additional antigens, particularly cohort studies to increase the body of evidence for protective immunity. More studies representing diverse geographical regions encompassing varying P. vivax endemicities are needed to validate the generalizability of the findings and to provide a solid evidence base for the use of P. vivax antigens in vaccines and serosurveillance tools.Electronic supplementary materialThe online version of this article (doi:10.1186/s12916-014-0150-1) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Immunological markers of Plasmodium vivaxexposure and immunity: a systematic review and meta-analysis

Cutts

Powell

Agius

et al. 2014

BMC Med

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“…lasmodium falciparum and Plasmodium vivax are both major causes of malaria morbidity and mortality in Southeast Asia (1,2). Clinical disease from these infections, malaria, is characterized by the presence of fever together with detectable Plasmodium parasites in the blood.…”

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confidence: 99%

Preserved Dendritic Cell HLA-DR Expression and Reduced Regulatory T Cell Activation in Asymptomatic Plasmodium falciparum and P. vivax Infection

et al. 2015

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“…In this regard, the host response influences the clinical expression of the disease. Fever may occur with low parasite densities and may be identified 2-3 days before the parasites are detected in blood, underscoring the need for serial peripheral blood smear examinations [8]; P. vivax has a lower pyrogenic threshold (parasitic density required to evoke a fever) compared with P. falciparum. Globally, it is estimated that there are more than 80 million episodes of P. vivax malaria every year resulting in a considerable amount of morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

Severe and Complicated Malaria due to Plasmodium vivax

Villamil-Gómez¹,

Eyes-Escalante²,

Franco‐Paredes³

2016

Current Topics in Malaria

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Contrary to the widespread belief that severe malaria is mainly caused by Plasmodium falciparum, malaria caused by Plasmodium vivax infection may also lead to severe clinical manifestations including a plethora of renal, pulmonary, hematologic, neurologic, and multiorgan dysfunction. Anemia and thrombocytopenia are considered as two major important markers of severity during the clinical course of severe P. vivax malaria. In highly endemic areas of P. vivax transmission, early diagnosis is crucial in preventing uncomplicated episodes progressing into severe and complicated clinical forms. In fact, given the wide geographic distribution of P. vivax, there is a large burden of disease, often not adequately acknowledged, and resulting from the combined effect of the large numbers of uncomplicated clinical episodes and the increasingly recognized severe and complicated clinical presentations.

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Plasmodium vivax

Cited by 184 publications

References 239 publications

Immunological markers of Plasmodium vivaxexposure and immunity: a systematic review and meta-analysis

Immunological markers of Plasmodium vivaxexposure and immunity: a systematic review and meta-analysis

Preserved Dendritic Cell HLA-DR Expression and Reduced Regulatory T Cell Activation in Asymptomatic Plasmodium falciparum and P. vivax Infection

Severe and Complicated Malaria due to Plasmodium vivax

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