Plasmonic Fiberoptic Absorbance Biosensor (P-FAB) for Rapid Detection of SARS-CoV-2 Nucleocapsid Protein

Divagar, M.; Gayathri, R.; Rasool, Rahiel; Shamlee, J Kuzhandai; Bhatia, Himanshu; Satija, Jitendra; Sai, V. V. R.

doi:10.1109/jsen.2021.3107736

Cited by 32 publications

(12 citation statements)

References 31 publications

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“…In addition, preclinical investigations and the development of a PoC read‐out device are in the plans. [ 116 ] A thin coating of GO was formed around the LPFG portion to generate functional groups for the biological recognition element immobilized by covalent bonds, as shown in Figure 3C. [ 117 ] The outside cladding of the LPFG has a greater refractive index than the inner cladding, allowing some cladding modes to be steered in the outer ring‐shaped cladding without interfering with the core mode.…”

Section: Principle Of Biosensor Detectionmentioning

confidence: 99%

Advancement in COVID‐19 detection using nanomaterial‐based biosensors

et al. 2023

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Coronavirus disease 2019 (COVID-19) pandemic has exemplified how viral growth and transmission are a significant threat to global biosecurity. The early detection and treatment of viral infections is the top priority to prevent fresh waves and control the pandemic. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified through several conventional molecular methodologies that are timeconsuming and require high-skill labor, apparatus, and biochemical reagents but have a low detection accuracy. These bottlenecks hamper conventional methods from resolving the COVID-19 emergency. However, interdisciplinary advances in nanomaterials and biotechnology, such as nanomaterials-based biosensors, have opened new avenues for rapid and ultrasensitive detection of pathogens in the field of healthcare. Many updated nanomaterials-based biosensors, namely electrochemical, field-effect transistor, plasmonic, and colorimetric biosensors, employ nucleic acid and antigen-antibody interactions for SARS-CoV-2 detection in a highly efficient, reliable, sensitive, and rapid manner. This systematic review summarizes the mechanisms and characteristics of nanomaterials-based biosensors for SARS-CoV-2 detection. Moreover, continuing challenges and emerging trends in biosensor development are also discussed. K E Y WO R D S colorimetric biosensor, COVID-19 detection, electrochemical biosensor, field-effect transistor biosensor, mass spectroscopy, plasmonic biosensor  Phuoc Loc Truong and Yiming Yin contributed equally to this work.

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Section: Principle Of Biosensor Detectionmentioning

confidence: 99%

Advancement in COVID‐19 detection using nanomaterial‐based biosensors

et al. 2023

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“…The proposed U-shaped fiber probe method has excellent sensitivity in the range of parts per billion (ppb), with a response time ranging from 25 to 60 s [30,31]. The steps followed for the fiber-optic-based sensing is summarized step by step in sections below according to the recent work shown in [32,33]. Figure 4…”

Section: Fiber-optic Sensing For Covid-19mentioning

confidence: 99%

“…The gold nanoparticles (AuNp) can be synthesized by citrate-mediated reduction of gold chloride. The biosensor matrix must first be produced by immobilizing gold nanoparticles on a U-bent fiber-optic probe by Satija et al 2014 in [33,34], then covalently conjugating anti-N protein monoclonal antibodies. For this reason, high-affinity antibodies will be obtained.…”

Section: Metallic Nanoparticles Synthesis and Immobilizationmentioning

confidence: 99%

SARS-CoV-2 Detection Using Optical Fiber Based Sensor Method

Hadi

Khurshid²

2022

Sensors

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The SARS-CoV-2 Coronavirus disease, also known as the COVID-19 pandemic, has engendered the biggest challenge to human life for the last two years. With a rapid increase in the spread of the Omicron variant across the world, and to contain the spread of COVID-19 in general, it is crucial to rapidly identify this viral infection with minimal logistics. To achieve this, a novel plastic optical fiber (POF) U-shaped probe sensing method is presented for accurate detection of SARS-CoV-2, commonly known as the COVID-19 virus, which has the capability to detect new variants such as Omicron. The sample under test can be taken from oropharyngeal or nasopharyngeal via specific POF U-shaped probe with one end that is fed with a laser source while the other end is connected to a photodetector to receive the response and postprocess for decision-making. The study includes detection comparison with two types of POF with diameters of 200 and 500 µm. Results show that detection is better when a smaller-diameter POF is used. It is also seen that the proposed test bed and its envisaged prototype can detect the COVID-19 variants within 15 min of the test. The proposed approach will make the clinical diagnosis faster, cheaper and applicable to patients in remote areas where there are no hospitals or clinical laboratories due to poverty, geographic obstacles, or other factors.

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“…In (Singh and Jha 2019 ), fabrication and validation of optical biosensor for non-invasive monitoring of glucose using saliva is proposed where the enzymatic reaction resulted in pH variation which was detected by electronic meter. In (Divagar et al 2021 ), a dip type, wash free plasmonic fiber optic absorbance biosensor (P-FAB) is proposed for point-of-care detection of SARS-CoV-2 N-protein. In (Monfared et al 2021 ), a highly sensitive quasi-D-shaped fiber optic biosensor is proposed for the detection of high refractive index liquid analytes via surface plasmon resonance.…”

Section: Introductionmentioning

confidence: 99%

Performance investigation of triple unsymmetrical micro ring resonator as optical filter as well as biosensor

Kisku¹,

Sarwagya²,

Ranjan³

2023

Opt Quant Electron

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Representation of triple unsymmetrical micro ring resonators (TUMRR) with single input and single output waveguide has been executed in this paper. Statistical demonstration of the presented arrangement is realized in the z-domain by a delay line signal processing method. The transfer function of the triple unsymmetrical micro ring resonator is calculated by Mason’s Gain rule. The offered arrangement is performed on SOI (Silicon in Insulator) platform to achieve the filtering and biochemical sensing intentions. To acquire field response of the arrangement, Finite difference time domain (FDTD) technique is used. Characteristics of optical filters are studied from the frequency response plot and the achieved free spectral range is 243.5 GHz. The shift in wavelength for biosensing application is accomplished through the OptiFDTD software. The sensitivity of the proposed TUMRR based biosensor is around 200–280 nm/RIU for different blood cells where as the Q-factor attained is 1938.

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Plasmonic Fiberoptic Absorbance Biosensor (P-FAB) for Rapid Detection of SARS-CoV-2 Nucleocapsid Protein

Cited by 32 publications

References 31 publications

Advancement in COVID‐19 detection using nanomaterial‐based biosensors

Advancement in COVID‐19 detection using nanomaterial‐based biosensors

SARS-CoV-2 Detection Using Optical Fiber Based Sensor Method

Performance investigation of triple unsymmetrical micro ring resonator as optical filter as well as biosensor

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