Plastic and Reconstructive Surgery

Stricker, Paul A.; Fiadjoe, John E.; Lerman, Jerrold

doi:10.1016/b978-0-323-42974-0.00035-5

“…Apigenin, a flavonoid found in Binahong, can increase the expression of TGF-β and PDGF (platelet-derived growth factor) that also function in fibroblast activation so that it can migrate towards the clot. 47 , 48 PDGF is also a protein that affects fibroblast proliferation. 48 Apigenin also has anti-inflammatory properties because it can inhibit the activation of NF-κB (nuclear factor kappa B).…”

Section: Discussionmentioning

confidence: 99%

Effects of 3% binahong (Anredera cordifolia) leaf extract gel on alveolar bone healing in post-extraction tooth socket wound in Wistar rats (Rattus norvegicus)

Hanafiah

¹

,

Hanafiah

²

,

Dohude

³

et al. 2022

View full text Add to dashboard Cite

Background: Binahong (Anredera cordifolia (Ten.) STEENIS) is a widely available herbal plant in Indonesia and has been intensely researched for its healing abilities due to its biological activities, but few have studied its capability in accelerating hard tissue healing in post-extraction tooth sockets. The purpose of this study was to analyse the effects of 3% binahong leaf extract gel on alveolar bone healing in post-extraction sockets in Wistar rats. Methods: In this study, 48 male Wistar rats were randomly allocated to twelve groups. After the extraction of the left mandibular incisor, sockets in Group I to IV were given 3% binahong leaf extract gel, group V to VIII were given a control gel, and group IX to XII were given Gengigel® for 14 days. The residual socket volume (RSV) and fibroblast proliferation were observed on the 3rd, 7th, and 14th day post-extraction, while the osteoblast and osteocyte proliferation were observed on the 7th, 14th, and 28th day post-extraction. The RSV data were analysed using repeated measure ANOVA and one-way ANOVA, while the histopathological data were analysed using one-way ANOVA. Results: The results showed that the binahong group had the lowest RSV and the highest fibroblast proliferation compared to the other groups on the 7th day (p<0.05) and the highest osteoblast and osteocyte proliferation compared to the other groups on the 14th day (p<0.05). Conclusion: The experiment showed that 3% binahong leaf extract gel could accelerate wound closure, which was characterized by a greater decrease in the RSV value in comparison to the other treatment groups and could enhance alveolar bone healing by increasing the proliferation of fibroblasts, osteoblasts, and osteocytes.

show abstract

“…36 Apigenin, a flavonoid found in binahong, can increase the expression of TGF-β and PDGF (platelet-derived growth factor) that also function in fibroblast activation so that it can migrate towards the clot. 37,38 PDGF is also a protein that affects fibroblast proliferation. 38 Apigenin also has anti-inflammatory properties because it can inhibit the activation of NF-κB (nuclear factor kappa B).…”

Section: Discussionmentioning

confidence: 99%

“…37,38 PDGF is also a protein that affects fibroblast proliferation. 38 Apigenin also has anti-inflammatory properties because it can inhibit the activation of NF-κB (nuclear factor kappa B). 39 Inhibited NF-κB can prevent the production of inflammatory mediators that can increase inflammation.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of 3% binahong (Anredera cordifolia) leaf extract gel on alveolar bone healing in post-extraction tooth socket wound in Wistar rats (Rattus norvegicus)

Hanafiah

¹

,

Hanafiah

²

,

Dohude

³

et al. 2021

View full text Add to dashboard Cite

Background: Binahong (Anredera cordifolia (Ten.) STEENIS) is a widely available herbal plant in Indonesia and has been intensely researched for its healing abilities due to its biological activities, but few have studied its capability in accelerating hard tissue healing in post-extraction tooth sockets. The purpose of this study was to analyse the effects of 3% binahong leaf extract gel on alveolar bone healing in post-extraction sockets in Wistar rats. Methods: In this study, 48 male Wistar rats were randomly allocated to twelve groups. After the extraction of the left mandibular incisor, sockets in Group I to IV were given 3% binahong leaf extract gel, group V to VIII were given a control gel, and group IX to XII were given Gengigel® for 14 days. The residual socket volume (RSV) and fibroblast proliferation were observed on the 3rd, 7th, and 14th day post-extraction, while the osteoblast and osteocyte proliferation were observed on the 7th, 14th, and 28th day post-extraction. The RSV data were analysed using repeated measure ANOVA and one-way ANOVA, while the histopathological data were analysed using one-way ANOVA. Results: The results showed that the binahong group had the lowest RSV and the highest fibroblast proliferation compared to the other groups on the 7th day (p<0.05) and the highest osteoblast and osteocyte proliferation compared to the other groups on the 14th day (p<0.05). Conclusion: The experiment showed that 3% binahong leaf extract gel could accelerate wound closure, which was characterized by a greater decrease in the RSV value in comparison to the other treatment groups and could enhance alveolar bone healing by increasing the proliferation of fibroblasts, osteoblasts, and osteocytes.

show abstract

“…2 Opioids are currently the first-line option for postoperative acute pain control after palatoplasty, though potential adverse effects include excessive sedation, nausea, and vomiting, increased intracranial pressure, respiratory depression, and death. 3,4 Thus, optimizing postoperative pain control using opioid-sparing techniques is critically important, especially in the pediatric population. 5 A number of nonopioid medications have been shown to reduce pain associated with PP.…”

mentioning

confidence: 99%

Administration of Intravenous Dexmedetomidine and Acetaminophen for Improved Postoperative Pain Management in Primary Palatoplasty

Ichiuji

¹

,

Mantilla-Rivas

²

,

Rana

³

et al. 2021

Journal of Craniofacial Surgery

View full text Add to dashboard Cite

Objective: Suboptimal pain management after primary palatoplasty (PP) may lead to complications such as hypoxemia, and increased hospital length of stay. Opioids are the first option for postoperative acute pain control after PP; however, adverse effects include excessive sedation, respiratory depression, and death, among others. Thus, optimizing postoperative pain control using opioid-sparing techniques is critically important. This paper aims to analyze efficacy and safety of combined intravenous (IV), dexmedetomidine, and IV acetaminophen during PP. Methods: Review of a cohort of patients who underwent PP from April 2009 to July 2018 at a large free-standing children's hospital was performed, comparing patients who received combined IV dexmedetomidine and acetaminophen with those who did not receive either of the 2 medications. Efficacy was measured through opioid and nonopioid analgesic dose and timing, pain scores, duration to oral intake, and length of stay. Safety was measured by 30-day complication rates including readmission for bleeding and need for supplementary oxygen. Results: Total postoperative acetaminophen (P ¼ 0.01) and recovery room fentanyl (P < 0.001) requirements were significantly lower in the study group compared with the control group. Length of stay, oral intake duration, pain scores, total postoperative opioid requirements, and complications rates trended favorably in the study group, though differences did not reach statistical significance. Conclusions:Intraoperative IV dexmedetomidine and acetaminophen during PP provides safe and effective perioperative pain control, resulting in statistically significant decreased need for postoperative acetaminophen and fentanyl. Larger studies are necessary to determine if other trends identified in this study may be significant.

show abstract

Plastic and Reconstructive Surgery

Cited by 4 publications

References 257 publications

Effects of 3% binahong (Anredera cordifolia) leaf extract gel on alveolar bone healing in post-extraction tooth socket wound in Wistar rats (Rattus norvegicus)

Effects of 3% binahong (Anredera cordifolia) leaf extract gel on alveolar bone healing in post-extraction tooth socket wound in Wistar rats (Rattus norvegicus)

Effects of 3% binahong (Anredera cordifolia) leaf extract gel on alveolar bone healing in post-extraction tooth socket wound in Wistar rats (Rattus norvegicus)

Administration of Intravenous Dexmedetomidine and Acetaminophen for Improved Postoperative Pain Management in Primary Palatoplasty

Contact Info

Product

Resources

About