Plasticity of the auditory brainstem: Cochleotomy-induced changes of calbindin-D28k expression in the rat

Förster, Christine R.; Illing, Robert‐Benjamin

doi:10.1002/(sici)1096-9861(20000110)416:2<173::aid-cne4>3.0.co;2-v

Cited by 50 publications

(30 citation statements)

References 47 publications

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“…1). There was a decreasing gradient in distribution of CB-immunostained cells from the superficial layers to the deep layers of the DCIC that continued into the central region of IC (Zettel et al, 1991;Kelley et al, 1992;Friauf, 1994;Forster and Illing, 2000). In contrast, the dense plexus of heavily CB-immunostained axonal fibers and endings was centered in CNIC and did not extend significantly toward paracentral regions (see CNIC in Fig.…”

Section: Cb-immunostained Afferent Compartment In Cnic In Neonatal Kimentioning

confidence: 99%

“…A survey of brainstem auditory nuclei in the CB-immunostained material indicated that projection cells in LSO and portions of ventral nucleus of the lateral lemniscus might contribute to such a CB-immunostained afferent plexus (see Zettel et al, 1991;Kelley et al, 1992;Friauf, 1994;Forster and Illing, 2000). There were no CB-immunostained projection cells in other nuclei such as DNLL and dorsal cochlear nucleus that previously have been shown to give rise to banded projections in the CNIC (see Oliver and Shneiderman, 1989 for review).…”

Section: Comparison Of Lso Bands With Cb-afferent Compartmentmentioning

confidence: 99%

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Quantitative assessment of developing afferent patterns in the cat inferior colliculus revealed with calbindin immunohistochemistry and tract tracing methods

2005

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The central nucleus of the inferior colliculus (CNIC) is comprised of an orderly series of fibrodendritic layers. These layers include integrative circuitry for as many as 13 different ascending auditory pathways, each tonotopically ordered. Calcium-binding proteins, such as calbindin-D28k (CB), may be useful neurochemical markers for specific subsets of afferent input in these layers and their spatial organization that are developmentally regulated. In this study, CBimmunohistochemistry was used to examine 1-42 postnatal-day-old kitten and adult cat CNIC and anterograde tracers were used to label afferent projections from the lateral superior olivary nucleus (LSO) to the CNIC at similar ages. A distinct axonal plexus that is CB-immunopositive is described. This CB-afferent compartment is present at birth and persists throughout the ages examined. Already at birth, the CB-immunostained plexus in kitten CNIC is organized into discrete bands that are approximately 75 μm thick and 500 μm long. In adult CNIC, the periodic banded pattern of CBimmunostained fibers is similar to that in kittens albeit bands are thicker (145 μm) and longer (700 μm). Growth in band thickness in adult cat appears proportional to growth of the IC, whereas length of the dense CB-immunostained bands is somewhat more focused in the central region of fibrodendritic layers. The banded pattern of the CB-immunostained plexus is well correlated with the location and dimension of afferent projections from the LSO in newborn kitten labeled with carbocyanine dye, 1,1′-dioctodecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate and in adult cat labeled with wheat germ agglutinin conjugated with horseradish peroxidase. The results reveal a neurochemical marker for one type of synaptic compartment in CNIC layers, banding, that is organized before hearing onset in kittens, but that may undergo some postnatal pruning. Keywords fibrodendritic laminae; banding pattern; calcium-binding proteins; lateral superior olivary nucleus; carbocyanine dyeIn the auditory midbrain, the inferior colliculus (IC) is comprised of a large, seemingly homogeneous, central nucleus (CNIC) surrounded by a complex and heterogeneous arrangement of several paracentral nuclei (Berman, 1968;Rockel and Jones, 1973a,b;Morest and Oliver, 1984 (Rockel and Jones, 1973a;Oliver and Morest, 1984). With only a few exceptions, all ascending hindbrain auditory pathways project to the CNIC and end in cochleotopic fashion within a series of these fibrodendritic layers. Overlaid on this network of hindbrain inputs are additional inputs from regions of auditory cortex and the contralateral IC as well as non-auditory structures (for review, see Oliver and Shneiderman, 1989). Less numerous are stellate cells and a subset of intrinsic axonal collaterals that depart from this laminar framework and cross laminar boundaries (Oliver et al., 1991).Overall, the stereotypical structure of the CNIC belies the underlying complexity, intrinsic structure, and functional relationships within layers that ...

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Section: Cb-immunostained Afferent Compartment In Cnic In Neonatal Kimentioning

confidence: 99%

Section: Comparison Of Lso Bands With Cb-afferent Compartmentmentioning

confidence: 99%

Quantitative assessment of developing afferent patterns in the cat inferior colliculus revealed with calbindin immunohistochemistry and tract tracing methods

2005

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“…In the intensity pathway, a subpopulation of neurons in NA was also shown to express CR immunoreactivity, but it was absent or weak in the terminal fields of the projection from NA to the midbrain, which were nonoverlapping in barn owl and chick Wang and Karten 2010). In the mammalian brain, multiple CaBPs show complementary patterns of expression within and across auditory brainstem nuclei and have been associated with specific subsets of cell types (Förster and Illing 2000;Fredrich et al 2009;Lohmann and Friauf 1996).…”

Section: Introductionmentioning

confidence: 99%

Heterogeneous Calretinin Expression in the Avian Cochlear Nucleus Angularis

Bloom

Williams

MacLeod

2014

JARO

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Multiple calcium-binding proteins (CaBPs) are expressed at high levels and in complementary patterns in the auditory pathways of birds, mammals, and other vertebrates, but whether specific members of the CaBP family can be used to identify neuronal subpopulations is unclear. We used double immunofluorescence labeling of calretinin (CR) in combination with neuronal markers to investigate the distribution of CR-expressing neurons in brainstem sections of the cochlear nucleus in the chicken (Gallus gallus domesticus). While CR was homogeneously expressed in cochlear nucleus magnocellularis, CR expression was highly heterogeneous in cochlear nucleus angularis (NA), a nucleus with diverse cell types analogous in function to neurons in the mammalian ventral cochlear nucleus. To quantify the distribution of CR in the total NA cell population, we used antibodies against neuronal nuclear protein (NeuN), a postmitotic neuronspecific nuclear marker. In NA neurons, NeuN label was variably localized to the cell nucleus and the cytoplasm, and the intensity of NeuN immunoreactivity was inversely correlated with the intensity of CR immunoreactivity. The percentage of CR+neurons in NA increased from 31 % in embryonic (E)17/18 chicks, to 44 % around hatching (E21), to 51 % in postnatal day (P) 8 chicks. By P8, the distribution of CR + neurons was uniform, both rostrocaudal and in the tonotopic (dorsoventral) axis.Immunoreactivity for the voltage-gated potassium ion channel Kv1.1, used as a marker for physiological type, showed broad and heterogeneous postsynaptic expression in NA, but did not correlate with CR expression. These results suggest that CR may define a subpopulation of neurons within nucleus angularis.

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“…Input-dependent changes during this critical period have dramatic effects in the CN, which manifests in differences in neuron numbers, growth of fibers, and establishment of synaptic contacts (3,4,30). Although some plastic changes also occur in the adult CN after afferent deprivation (31,32), the most dramatic effects occur during the critical period that in mice extends from birth until the second week of life (6). Despite many studies of neuron loss, as well as an extensive study of changes in global gene expression during the critical period in the afferent deprived CN (10), no in-depth studies that focus on the mechanisms that bestow plasticity have been conducted in the auditory brainstem.…”

Section: Discussionmentioning

confidence: 99%

Transient, afferent input-dependent, postnatal niche for neural progenitor cells in the cochlear nucleus

Volkenstein

Oshima

Sinkkonen

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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Significance The cochlear nucleus is the first central relay station for auditory signals from the cochlea. Like many other central relays for sensory systems, the cochlear nucleus features a period in newborn animals during which neuron survival and the number of synaptic contacts depends on afferent innervation from the periphery. This study extends this concept of postnatal plasticity toward neurogenesis. We identified neural progenitor cells in the cochlear nucleus whose proliferative capacity is controlled by interplay of several signaling pathways. When the cochlea was removed, the proliferating cell population diminished, suggesting that signals from the periphery are required to maintain this plasticity.

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Plasticity of the auditory brainstem: Cochleotomy-induced changes of calbindin-D28k expression in the rat

Cited by 50 publications

References 47 publications

Quantitative assessment of developing afferent patterns in the cat inferior colliculus revealed with calbindin immunohistochemistry and tract tracing methods

Quantitative assessment of developing afferent patterns in the cat inferior colliculus revealed with calbindin immunohistochemistry and tract tracing methods

Heterogeneous Calretinin Expression in the Avian Cochlear Nucleus Angularis

Transient, afferent input-dependent, postnatal niche for neural progenitor cells in the cochlear nucleus

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