Plasticizers: A Vital Excipient in Novel Pharmaceutical Formulations

Mishra, Ashwani Kumar; Pathak, Anupam

doi:10.24092/crps.2017.070101

Cited by 9 publications

(8 citation statements)

References 7 publications

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“…In pharmaceutical formulations, the use of polyols may depress the glass transition temperature of the system in the range of 213–213 K for non-aqueous solvents, and below 348 K for aqueous systems [ 51 , 52 ]. This is important in the field of drug release where the releasing temperature may be modified by the addition of a plasticizer [ 53 ].…”

Section: Resultsmentioning

confidence: 99%

Thermal Study of Polyols for the Technological Application as Plasticizers in Food Industry

et al. 2018

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In this work is presented the complete thermal analysis of polyols by direct methods such as simultaneous thermogravimetric and differential thermal analyzer (TGA-DTA), differential scanning calorimetry (DSC), modulated DSC (MDSC), and supercooling MDSC. The different thermal events in the temperature range of 113–553 K were identified for glycerol (GL), ethylene glycol (EG), and propylene glycol (PG). Boiling temperature (TB) decreased as GL > EG > PG, but increased with the heating rate. GL showed a complex thermal event at 191–199 K, identified as the glass transition temperature (Tg) and devitrification temperature (Tdv), and a liquid–liquid transition (TL-L) at 215–221 K was identified as the supercooling temperature. EG showed several thermal events such as Tg and Tdv at 154 K, crystallization temperature (Tc) at 175 K, and melting temperature (Tm) at 255 K. PG also showed a complex thermal event (Tg and Tdv) at 167 K, a second devitrification at 193 K, and TL-L at 245 K. For PG, crystallization was not observed, indicating that, during the cooling, the liquid remained as an amorphous solid.

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Section: Resultsmentioning

confidence: 99%

Thermal Study of Polyols for the Technological Application as Plasticizers in Food Industry

et al. 2018

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“…The changes in surface texture on treatment with drug loading solution have permitted more drug adsorption on the rough filaments (16) and contributed to higher drug loading of these filaments. The reduction in values of elastic modulus (~25%) and stiffness (~35%) as observed in those filaments containing solubilizer and/or plasticizer (or treatment with microwave energy) indicated the plasticizer effect of these substances or treatment resulting in the increase of overall solubility of drug and changes the molecular packing of filament making it more diffusible for the drug (17). This subsequently has caused an increased penetration of drug solution into the filament core, hence the enhanced drug loading.…”

Section: Discussionmentioning

confidence: 99%

Effect of Solublising Aids on The Entrapment of Loratidine in Pre-Fabricated PVA Filaments Used for FDM Based 3D-Printing

Mahmood

Hussain

Arshad

et al. 2020

Acta Poloniae Pharmaceutica - Drug Research

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Fused deposition modeling (FDM) based threedimensional printing (3DP) is amongst a recently used methods intended for the preparation of customized medicine (1). Dose customization involves; tailoring the medical treatment based on the individual characteristics, needs and preferences of each patient (2). This approach can improve the safety profile of drugs by lowering the risk of overdosing (particularly for drugs prescribed at lower doses), hence adverse reactions (3). FDM is an additive manufacturing technique (4) which constructs a 3D object directly from computer-aided design (CAD) data, utilizing a thermoplastic material (such as PVA and PLA, etc.) in the form of filament extruded through printing head of 3D printer in a layer by layer fashion (5). The classical approach for drug loading in commercially available PVA or PLA filaments is the impregnation or solvent diffusion (6). The method involves soaking the filament in the saturated alcoholic solution of a drug at room temperature (7). The preparations reported so far have shown a meager drug loading i.e. (< 2% w/w) by this method. In one such study, fluorescein sodium was loaded in PVA filament. Although the printed tablets were mechanically strong with low friability, they exhibited a drug content of <1% (6). Similarly, 3D printing of 4-aminosalicylic acid (4-ASA) and 5-aminosalicylic acid (5-ASA) tablets also revealed almost similar extent of drug loading (8). The impregnation method has also been tried for 3D printing of pred

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“…It seems that for solvent cast film, there is an essential need to use plasticizer such as glycerol or polyethylene glycol in order to improve the flexibility and to reduce the brittleness. However, electrospun films have a substantial appropriate flexibility and plasticizer is not included in the preparation process [43].…”

Section: Mechanical Propertiesmentioning

confidence: 99%

A comparison between solvent casting and electrospinning methods for the fabrication of neem extract-containing buccal films

Shirvan

Hemmatinejad

Bahrami

et al. 2021

Journal of Industrial Textiles

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In the present study a double layer mucoadhesive buccal film containing nanocarriers encapsulated with neem extract was fabricated through electrospinning and solvent casting techniques for dental therapeutic applications. The morphological, physical and mucoadhesive properties of the resulting electrospun and solvent cast oral films were mutually compared, and their drug release behavior and antibacterial activity were further investigated. Chitosan/poly(vinylalcohol) (PVA) as a mucoadhesive component and phenylalanine amino acid nanotubes (PhNTs)-containing neem extract as a drug nanocarrier were used to fabricate oral films. A poly(caprolactone) (PCL) layer was used as an impermeable backing layer to protect the mucoadhesive component from tongue movement and drug loss. The results indicated an interconnected porous and fully filled solid structures for electrospun and solvent cast films, respectively. The physicomechanical parameters of the samples such as pH, weight, thickness, folding endurance and tensile strength were also evaluated. The crosslinked electrospun buccal film indicated better swelling and mucoadhesive properties compared to the solvent cast film. In addition, the drug loading capacity and encapsulation efficiency of the solvent cast film showed lower experimental values than those of electrospun oral film. On the other hand, the electrospun oral film had a well-controlled release of neem extract up to 82% at oral pH, which is best fitted to the Weibull model, and demonstrated the highest antibacterial properties against S. mutans bacteria with high biocompatibility on L929 fibroblast cells. Generally, the synthesized electrospun mucoadhesive film has a better potential for oral therapeutic applications than the solvent cast film.

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Plasticizers: A Vital Excipient in Novel Pharmaceutical Formulations

Cited by 9 publications

References 7 publications

Thermal Study of Polyols for the Technological Application as Plasticizers in Food Industry

Thermal Study of Polyols for the Technological Application as Plasticizers in Food Industry

Effect of Solublising Aids on The Entrapment of Loratidine in Pre-Fabricated PVA Filaments Used for FDM Based 3D-Printing

A comparison between solvent casting and electrospinning methods for the fabrication of neem extract-containing buccal films

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