Platelet-Activating Factor and Leukotrienes in Acute Otitis Media, Secretory Otitis Media, and Chronic Otitis Media on the Acute Excerbation

Tachibana, Fumitoshi; Shimada, T; Hori, Yohji; Wada, Yoshizumi; Ishitani, Yasuo; Koike, Yasuo

doi:10.1016/s0385-8146(96)80004-6

Cited by 12 publications

(9 citation statements)

References 8 publications

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“…Platelet‐activating factor (PAF), a low‐molecular‐weight phospholipid, is a strong mediator of inflammation. This potent chemotactic factor is produced by a variety of cells and has been found in MEE 13,14 . Intratympanic administration of PAF caused reduced ciliary activity and prolonged the mucociliary clearance time of the tubotympanium.…”

Section: Inflammatory Mediators In Middle‐ear Effusionsmentioning

confidence: 98%

Effects of Inflammatory Mediators on Middle Ear Pathology and on Inner Ear Function

Juhn

Jung

Lin

et al. 1997

Annals of the New York Academy of Sciences

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Section: Inflammatory Mediators In Middle‐ear Effusionsmentioning

confidence: 98%

Effects of Inflammatory Mediators on Middle Ear Pathology and on Inner Ear Function

Juhn

Jung

Lin

et al. 1997

Annals of the New York Academy of Sciences

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“… 68–70 Other substances identified include bacterial products, immunoglobulins, lysozyme, lactoferrin, complement components, leukotrienes and cytokines 5,6 . 27,53 , 64,71–73 …”

Section: What Is In the Effusion?mentioning

confidence: 99%

The aetiology of otitis media with effusion: a review

2000

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Otitis media with effusion (OME) is the most common cause of deafness in children in the developed world. In this article we aim to present an overview of current research developments on the aetiology of OME and the resulting implications for treatment. In the model we describe, the primary event is inflammation of the middle ear mucosa, usually due to the presence of bacteria. This leads to the release of inflammatory mediators, which cause secretion of a mucin-rich effusion by up-regulating mucin genes. Prolonged stimulation of the inflammatory response and poor mucociliary clearance lead to persistence of the middle ear fluid, giving rise to the clinical presentation of OME. We describe OME in the following sequence: the initial production of the effusion, the composition of the effusion produced, and factors impairing clearance of the effusion.

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“…Cysteinyl leukotrienes are products of arachidonic acid metabolism and are released by various cells that are involved in the inflammatory cascade. Arachidonic acid metabolites are important in the pathogenesis of middle ear effusion and may even be responsible for the sensorineural hearing loss that is occasionally observed with OME [4,14]. …”

Section: Introductionmentioning

confidence: 99%

Montelukast is as effective as penicillin in treatment of acute otitis media: An experimental rat study

Uçar

Huseynov

Çoban

et al. 2013

Med Sci Monit Basic Res

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BackgroundLeukotrienes are the major factors in the formation of edema and mucus, as well as development of tuba Eustachii dysfunction in acute otitis media. We developed an experimental acute suppurative otitis media model and compared the responses of rats to penicillin and combinations of leukotriene antagonist with respect to histopathological observations conducted in early and late phases.Material/MethodsA total of 83 ears from 56 Wistar rats were used in this study. Pneumococcus suspension was injected trans-tympanically into all rats. Subjects were classified into 4 different groups with 14 rats in each. In Group A, intramuscular penicillin G was injected for a period of 5 days. In Group B, intraperitoneal montelukast was injected for 21 days in addition to penicillin. In Group C, intraperitoneal montelukast isotonic NaCl in Group D was injected into rats for 21 days.ResultsNo significant difference was found between the groups, except for mucosal vascularization with respect to mucosal and TM parameters in early phases. Furthermore, considerable deviations were observed for the recuperation of TM and mucosal inflammation for groups in which subjects were injected with montelukast as compared to other groups of the study in the late phases.ConclusionsWhen the parameters of inflammation in the rat middle ear were compared with each other, most of these parameters did not show any statistically significant beneficial effects in montelukast and penicillin groups.

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Platelet-Activating Factor and Leukotrienes in Acute Otitis Media, Secretory Otitis Media, and Chronic Otitis Media on the Acute Excerbation

Cited by 12 publications

References 8 publications

Effects of Inflammatory Mediators on Middle Ear Pathology and on Inner Ear Function

Effects of Inflammatory Mediators on Middle Ear Pathology and on Inner Ear Function

The aetiology of otitis media with effusion: a review

Montelukast is as effective as penicillin in treatment of acute otitis media: An experimental rat study

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