2022
DOI: 10.1002/biof.1908
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Platelet activating factor: Have we been missing the forest for the trees?

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Cited by 3 publications
(3 citation statements)
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“…Interestingly, S protein has been shown to augment PAF production. In the presence of S protein, PAF-induced aggregation in human platelet-rich plasma (hPRP) from non-vaccinated individuals is enhanced [245]. Hence, scientists have highlighted PAF inhibition as a potential target for drug development in COVID-19.…”
Section: Potential Role Of Phytochemicals In Prophylaxis and Therapy ...mentioning
confidence: 99%
“…Interestingly, S protein has been shown to augment PAF production. In the presence of S protein, PAF-induced aggregation in human platelet-rich plasma (hPRP) from non-vaccinated individuals is enhanced [245]. Hence, scientists have highlighted PAF inhibition as a potential target for drug development in COVID-19.…”
Section: Potential Role Of Phytochemicals In Prophylaxis and Therapy ...mentioning
confidence: 99%
“…Subsequently PAF is implicated in platelet aggregation and microthromboses and thrombosis formation in nonvaccination subjects. 43,44 PAF can be produced by many cells, but the most important producers of this factor are: platelets, macrophages, monocytes, eosinophils, basophils, endothelial cells, and renal cells. 45 Endothelial cells produce PAF in response to thrombin, vesopressin, IL-1 and anti-factor VIII.…”
Section: Paf and Food Anaphylaxismentioning
confidence: 99%
“…Interestingly, the coronavirus spike protein modulates the PAF production. Subsequently PAF is implicated in platelet aggregation and microthromboses and thrombosis formation in non‐vaccination subjects 43,44 …”
Section: Paf and Food Anaphylaxismentioning
confidence: 99%