Platelet activation is caused not by aging but by atherosclerosis

Kurabayashi, Hitoshi; Kubota, Keiichi; Hishinuma, Akiko; Majima, Mitsuru

doi:10.1016/j.archger.2009.10.009

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…In earlier studies, it was generally accepted that increased platelet activation is related to cerebral infarction and coronary heart disease, while recent reports have shown controversial results regarding the association between MPV and stroke. 6 , 11 O’Malley et al 12 reported a higher elevated MPV in patients with acute and chronic ischemic stroke than in controls, but they did not find any significant distinction in the MPV values between the acute and chronic phases of stroke. They also speculated that changes precede the vascular event.…”

Section: Discussionmentioning

confidence: 95%

Predictive and prognostic role of mean platelet volume in patients with first-ever acute ischemic stroke

Lök

Gülaçtı

Ekmekçi

et al. 2017

NSJ

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Objective:To investigate any possible effects of mean platelet volume (MPV) on short-term stroke prognosis and functional outcome in patients with first-ever acute ischemic stroke (FEAIS).Methods:This retrospective cross-sectional study included 798 FEAIS patients admitted to the emergency department of a tertiary care hospital in Adiyaman, Turkey between January 2013 and June 2015. The data were evaluated according to whether alive or dead, MPV levels, modified Rankin scale (MRS) scores, National Institutes of Health Stroke Scale (NIHSS) scores. The patients were divided into 3 groups based on MPV level as 4.4-7.4 fL, 7.5-10.4 fL, higher than 10.4 fL.Results:A total of 250 patients with FEAIS were included in the study. In both those who survived and those who died, the area under the curve related to hospitalization days, time interval of venipuncture (TIV), and MPV measurements was not statistically significant (p>0.05). The 3 MPV groups showed no significant differences in terms of MRS score, median NIHSS score, hospitalization, and TIV. In subgroups based on MRS scores, there were no statistically significant differences according to median latency (p=0.087), median hospitalization (p=0.394), TIV (p=0.201), and MPV levels (p=0.847). Furthermore, there were no differences in MPV levels between the MRS based groups (p=0.527).Conclusion:The results showed that MPV was not a significantly associated and reliable marker for the prediction of prognosis or functional outcome of FEAIS attack.

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Section: Discussionmentioning

confidence: 95%

Predictive and prognostic role of mean platelet volume in patients with first-ever acute ischemic stroke

Lök

Gülaçtı

Ekmekçi

et al. 2017

NSJ

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“…However, causality is difficult to establish in observational studies, and inverse causality has also been suggested. Kurabayashi et al have suggested that the enhanced platelet activity observed in the elderly is caused by underlying atherosclerosis rather than by the aging process (94). They have examined shape change and peroxidase content of platelets from a small group of young and old subjects with or without atherosclerosis.…”

Section: Aging Platelet Hyperactivity and Coexisting Diseasesmentioning

confidence: 99%

Platelet Function in Aging

Blanc

Lordkipanidzé

2019

Front. Cardiovasc. Med.

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Aging is associated with an increased incidence of cardiovascular disease and thrombosis. Platelets play a major role in maintaining hemostasis and in thrombus formation, making them a key player in thrombotic disorders. Whereas it is well-known that platelet aggregability is increased in vascular diseases, the contribution of age-related changes in platelet biology to cardiovascular risk is not well-understood. Several lines of evidence support that platelets from older subjects differ in their function and structure, making platelets more prone to activation and less sensitive to inhibition. These age-related changes could lead to platelet hyperactivity and to the development of a prothrombotic state in advanced age. This review will focus on platelet biochemical modifications during aging and on the mechanisms by which these alterations could lead to thrombotic disease.

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“…Data are compatible with platelet pre-activation in atherosclerotic patients, similar but lower compared to patients with AIS or chronic phase. Pre-activated platelets showed a higher density of pseudopods and vacuoles ( Kurabayashi et al, 2000 , 2010 ). The endothelial damage reported in atherosclerosis, combined with a pre-activated state of platelets, is the most plausible factor for inflammatory-mediated CNS damage that accelerates the major hypoxic injury.…”

Section: Cerebrovascular Diseasesmentioning

confidence: 99%

Neuro-Immune Hemostasis: Homeostasis and Diseases in the Central Nervous System

Luca

Colangelo

Alberghina

et al. 2018

Front. Cell. Neurosci.

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Coagulation and the immune system interact in several physiological and pathological conditions, including tissue repair, host defense, and homeostatic maintenance. This network plays a key role in diseases of the central nervous system (CNS) by involving several cells (CNS resident cells, platelets, endothelium, and leukocytes) and molecular pathways (protease activity, complement factors, platelet granule content). Endothelial damage prompts platelet activation and the coagulation cascade as the first physiological step to support the rescue of damaged tissues, a flawed rescuing system ultimately producing neuroinflammation. Leukocytes, platelets, and endothelial cells are sensitive to the damage and indeed can release or respond to chemokines and cytokines (platelet factor 4, CXCL4, TNF, interleukins), and growth factors (including platelet-derived growth factor, vascular endothelial growth factor, and brain-derived neurotrophic factor) with platelet activation, change in capillary permeability, migration or differentiation of leukocytes. Thrombin, plasmin, activated complement factors and matrix metalloproteinase-1 (MMP-1), furthermore, activate intracellular transduction through complement or protease-activated receptors. Impairment of the neuro-immune hemostasis network induces acute or chronic CNS pathologies related to the neurovascular unit, either directly or by the systemic activation of its main steps. Neurons, glial cells (astrocytes and microglia) and the extracellular matrix play a crucial function in a “tetrapartite” synaptic model. Taking into account the neurovascular unit, in this review we thoroughly analyzed the influence of neuro-immune hemostasis on these five elements acting as a functional unit (“pentapartite” synapse) in the adaptive and maladaptive plasticity and discuss the relevance of these events in inflammatory, cerebrovascular, Alzheimer, neoplastic and psychiatric diseases. Finally, based on the solid reviewed data, we hypothesize a model of neuro-immune hemostatic network based on protein–protein interactions. In addition, we propose that, to better understand and favor the maintenance of adaptive plasticity, it would be useful to construct predictive molecular models, able to enlighten the regulating logic of the complex molecular network, which belongs to different cellular domains. A modeling approach would help to define how nodes of the network interact with basic cellular functions, such as mitochondrial metabolism, autophagy or apoptosis. It is expected that dynamic systems biology models might help to elucidate the fine structure of molecular events generated by blood coagulation and neuro-immune responses in several CNS diseases, thereby opening the way to more effective treatments.

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Platelet activation is caused not by aging but by atherosclerosis

Cited by 6 publications

References 23 publications

Predictive and prognostic role of mean platelet volume in patients with first-ever acute ischemic stroke

Predictive and prognostic role of mean platelet volume in patients with first-ever acute ischemic stroke

Platelet Function in Aging

Neuro-Immune Hemostasis: Homeostasis and Diseases in the Central Nervous System

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