Platelet Activity Indices in Patients With Deep Vein Thrombosis

Çay, Nurdan; İpek, Ali; Gümüş, Mehmet; Birkan, Zülfü; Özmen, Evrim

doi:10.1177/1076029611419841

Cited by 22 publications

(28 citation statements)

References 23 publications

(26 reference statements)

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“…39 Platelet activation occurs in patients with DVT. [6][7][8] Although conflicting results have been reported, 40 the majority of studies to date have highlighted an increase in platelet size with aging, 13 providing a potential explanation for higher thrombotic risk in aged individuals. [3][4][5] As larger platelets contain more granules and express procoagulant surface proteins and adhesion molecules, they display greater prothrombotic potential.…”

Section: Discussionmentioning

confidence: 99%

“…Platelet activation is a link in the pathophysiology of diseases prone to thrombosis and is viewed as a therapeutic target in thromboembolism. [6][7][8][9] Platelet size, measured as mean platelet volume (MPV), is considered a marker of its function and positively associated with indicators of platelet activity, including aggregation and production of thrombogenic factors, such as thromboxane A2, von Willebrand factor (VWF), platelet factor 4 (PF4), b-thromboglobulin, and P-selectin. [10][11][12] A number of population studies have shown that MPV and platelet activation increase with age, 13 implying an essential role of these factors in aging-related VTE.…”

Section: Introductionmentioning

confidence: 99%

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mTORC1 promotes aging-related venous thrombosis in mice via elevation of platelet volume and activation

Yang¹,

Zhou

Fan³

et al. 2016

Blood

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mTORC1 promotes aging-related venous thrombosis in mice via elevation of platelet volume and activation

Yang¹,

Zhou

Fan³

et al. 2016

Blood

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“…The relationship between increased number of platelets and venous thrombosis was demonstrated by various studies 18,19 . Additionally, it was accepted that the PLR value obtained by dividing the number of platelets by the number of lymphocytes is an indicator of both inflammatory and thrombotic events [20][21][22] .…”

Section: Discussionmentioning

confidence: 99%

“…A study found that increased MPV values are an indicator in development of venous thromboses such as deep venous thrombosis and pulmonary embolism [16][17][18] . In a study by Kamisli et al, it was found that MPV and PDW values in acute period CVST patients were higher than those of controls, and the same values were also higher in patients with parenchymal lesions than those without 12 .…”

Section: Discussionmentioning

confidence: 99%

The role of mean platelet volume, platelet distribution width and platelet / lymphocyte ratio in development of cerebral venous thrombosis

Bolayir¹,

Gökçe²

2017

Cumhuriyet Medical Journal

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SUMMARYObjective: Mean platelet volume (MPV) and platelet distribution width (PDW) are parameters that indicate platelet volume. It is assumed that large platelets are enzymatically and metabolically more active than small platelets. The relationship between elevated MPV and PDW values and arterial thrombosis has been demonstrated, but their roles in venous thrombosis are not fully understood. While the platelet / lymphocyte ratio (PLR), which is considered to be an inflammatory indicator, is known to be associated with many diseases, there are only a few studies in venous thrombosis. For this reason, our aim in this study is to establish the relationship between MPV, PDW and PLR values and cerebral venous sinus thrombosis (CVST). Method: Our study included 54 patients who were diagnosed with CVST in our clinic between January 2008 and September 2016, and 50 controls with similar age and sex. The patients and control groups were compared in terms of MPV, PDW and PLR values. In addition, the patient group was divided into two groups, according to parenchymal brain lesions, and the effect of MPV, PDW, and PLR on prognosis was also assessed. Results: While the MPV, PDW and PLR values were higher in the patient group compared to the controls, there was no significant difference between patients with and without parenchymal lesions. In addition, as MPV and PDW values for CVST development were determined as significant independent variables, optimal cut-off values were identified 8.85 for MPV, 15.75 for PDW and 168.53 for PLR in ROC analysis. Conclusions: As a result, MPV, PDW and PLR values were higher in patients with SVST than controls, however their prognostic significance was not determined. In addition, we may suggest that higher MPV and PDW values are new independent risk factors for CVST development. Keywords: Mean platelet volüme, Platelet distribution width, platelet / lymphocyte ratio, cerebral venous thrombosis ÖZET Amaç: Ortalama platelet hacmi (OPH) ve platelet dağılım genişliği (PDG), platelet hacmini gösteren parametrelerdir. Büyük plateletlerin küçük plateletlere kıyasla enzimatik ve metabolik olarak daha aktif kabul edilmektedir. Artmış OPH ve PDG değerleri ile arteryel tromboz arasındaki ilişki gösterilmiştir ancak venöz trombozdaki yeri tam olarak bilinmemektedir. İnflamatuar bir gösterge kabul edilen platelet/ lenfosit oranının artışının(PLO) birçok hastalıkla ilişkisi bilinmekteyken venöz trombozda kullanımı ile ilgili az sayıda çalışma mevcuttur. Bu nedenle bu çalışmamızdaki amacımız OPH, PDG ve PLO değerleri ile serebral venöz sinüs trombozu(SVST) arasındaki ilişkiyi ortaya koymaktır. Yöntem: Çalışmamıza retrospektif olarak Ocak 2008-Eylül 2016 tarihleri arasında kliniğimizde SVST tanısı ile izlenmiş 54 hasta ile benzer yaş ve cinsiyete sahip 50 kontrol dahil edildi. Hasta ve kontrol grubu OPH, PDG ve PLO değerleri açısından kıyaslandı. Bunun yanında hasta grubu kendi içinde beyin parankimal lezyonu olan ve olmayanlar olarak ikiye ayrılarak OPH, PDG ve PLO'nun prognoz üzerindeki etkisi de değer...

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“…However, doppler US is the prefferred method because it is noninvasive, safe, and inexpensive. [4] Recent advances in automated blood cell analyzers have made it possible to obtain new information about platelets through the measurement of platelet indices, including mean platelet volume (MPV). MPV is an indicator of platelet activation, which has an important role in the pathophysiology of thrombosis.…”

Section: Introductionmentioning

confidence: 99%

Is Increased Mean Platelet Volume a Risk Factor in Patients with Acute Deep Vein Thrombosis?

et al. 2012

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ÖZET Amaç Bu retrospektif çalışmanın amacı, ortalama tombosit hacmini, akut derin ven trombozlu (DVT) hastalarda ve kontrol grubunda karşılaş-tırmaktır. Gereç ve Yöntem SUMMARY ObjectivesThe purpose of this retrospective study was to compare the mean platelet volume between the patients with acute deep vein thrombosis (DVT) and control subjects. MethodsData were collected retrospectively from the patients' medical records. The study group consisted of 110 patients with newly diagnosed acute DVT in the lower extremities. An age, gender, and body mass index-matched control group consisted of 98 patients with normal duplex ultrasound findings. We compared the mean platelet volume in patients with acute DVT and control participants. ResultsThere was no significant difference between the study and control groups in mean platelet volume (8.8±1.6 vs 8.7±1.3 fl, respectively; p>0.05). Age (p=0.899), body mass index (p=0.43), gender (p=0.466), and platelet count (p=0.886) were statistically similar in both groups. ConclusionsThere was no significant difference in mean platelet volume between patients with acute DVT and the control group. According to our result, we propose that mean platelet volume should not be considered as an index of acute DVT.

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Platelet Activity Indices in Patients With Deep Vein Thrombosis

Abstract: In patients with DVT, the presence of DVT was closely associated with increased platelet activation. The MPV, MPM, and MPC may identify patients requiring aggressive antiplatelet treatment.

Cited by 22 publications

References 23 publications

mTORC1 promotes aging-related venous thrombosis in mice via elevation of platelet volume and activation

mTORC1 promotes aging-related venous thrombosis in mice via elevation of platelet volume and activation

The role of mean platelet volume, platelet distribution width and platelet / lymphocyte ratio in development of cerebral venous thrombosis

Is Increased Mean Platelet Volume a Risk Factor in Patients with Acute Deep Vein Thrombosis?

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