2022
DOI: 10.1016/j.cca.2022.09.015
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Platelet–Acute Leukemia Interactions

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Cited by 7 publications
(2 citation statements)
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“…Studies showed that cytogenetic or molecular abnormalities had an influence on proliferation and differentiation of MKs as well as platelets production in AML patients [ 32 , 50 ]. The thrombopoietin (TPO)/myeloproliferative leukemia virus oncogene (MPL) pathway plays a critical role in both normal and malignant hematopoiesis and megakaryopoiesis [ 51 , 52 ].…”
Section: Discussionmentioning
confidence: 99%
“…Studies showed that cytogenetic or molecular abnormalities had an influence on proliferation and differentiation of MKs as well as platelets production in AML patients [ 32 , 50 ]. The thrombopoietin (TPO)/myeloproliferative leukemia virus oncogene (MPL) pathway plays a critical role in both normal and malignant hematopoiesis and megakaryopoiesis [ 51 , 52 ].…”
Section: Discussionmentioning
confidence: 99%
“…Similarly, eosinophils and basophils also infiltrate multiple tumors and are activated to regulate tumor progression, either by directly interacting with cancer cells or indirectly by modulating the TME ( 185 188 ). Platelets, small anucleate structures derived from BM megakaryocytes, have also been shown to play a broad role in tumor progression, and favor proliferation from the release of growth factors and drug resistance ( 189 191 ). In addition, they act in the formation of secondary niches through a mechanism called “cloaking”, in which platelets produce physical protection in cancer cells, thus assisting in vascular migration and extravasation to the tissues to form metastases ( 192 194 ).…”
Section: Concluding Remarks and Future Perspectivesmentioning
confidence: 99%