Platelet adhesion and protein adsorption on silicone rubber surface by ozone-induced grafted polymerization with carboxybetaine monomer

Zhou, Jian; Yuan, Jiang; Zang, Xiaopeng; Shen, Jian; Lin, Sicong

doi:10.1016/j.colsurfb.2004.11.006

Cited by 62 publications

(44 citation statements)

References 25 publications

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“…[17,18] Other research groups also have reported that modification of solid surfaces with carboxybetaine polymers reduced protein adsorption and platelet adhesion. [19,20] However, the biocompatibility (in other words, anti-biofouling property) of ''carboxybetaine copolymers'' has not been evaluated in detail.…”

Section: Introductionmentioning

confidence: 99%

Anti‐Biofouling Properties of Polymers with a Carboxybetaine Moiety

Tada¹,

Inaba²,

Mizukami³

et al. 2008

Macromolecular Bioscience

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The resistance of random copolymers of BMA and CMB against biofouling was evaluated. The amount of proteins adsorbed onto the CMB copolymers was smaller than that onto other polymers (non-ionic polymers and copolymers of ordinary ionic monomers and BMA) and decreased with an increase in the content of CMB residues. Furthermore, there was a dramatic decrease in the number of cells (platelets and fibroblasts) that adhered to the CMB copolymers compared with that to other polymers. In contrast with this, CMB copolymers were slightly perturbative to both complement and coagulation systems. However, the overall results suggest that zwitterionic moieties are effective for making polymer materials biocompatible due to their excellent anti-biofouling property.

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Section: Introductionmentioning

confidence: 99%

Anti‐Biofouling Properties of Polymers with a Carboxybetaine Moiety

Tada¹,

Inaba²,

Mizukami³

et al. 2008

Macromolecular Bioscience

View full text Add to dashboard Cite

show abstract

“…In particular, the latter profits from the facile incorporation of reactive groups in special positions, e.g., in the center or at the ends of the polymers, that enable efficient attachment of the macromolecules onto the substrates. Still, classical grafting-from [318][319][320][321][322][323][324][325][326][327][328][329][330][331][332][333][334][335], grafting-to [336][337][338][339][340][341][342][343][344][345][346], and grafting-through [316,347] procedures are of course continuously in use, especially in industrial applications, where the activation of the surfaces for the grafting process by physical means or by simple, "unpretentious" chemistry is preferred for reasons of experience, cost and high-throughput.…”

Section: Synthesis By Chain Growth Polymerizationsmentioning

confidence: 99%

Structures and Synthesis of Zwitterionic Polymers

2014

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Abstract:The structures and synthesis of polyzwitterions ("polybetaines") are reviewed, emphasizing the literature of the past decade. Particular attention is given to the general challenges faced, and to successful strategies to obtain polymers with a true balance of permanent cationic and anionic groups, thus resulting in an overall zero charge. Also, the progress due to applying new methodologies from general polymer synthesis, such as controlled polymerization methods or the use of "click" chemical reactions is presented. Furthermore, the emerging topic of responsive ("smart") polyzwitterions is addressed. The considerations and critical discussions are illustrated by typical examples.

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“…The relationship between the physicochemical state of surface and blood compatibility of the materials is of topical concern [6]. Various studies have shown that the interfacial interactions are related to surface properties such as surface chemical composition, surface wettability and surface roughness [7][8][9]. Our study is undertaken to examine how arrays of pillars/grooves surface and wettability affect platelet adhesion.…”

Section: Introductionmentioning

confidence: 99%

Blood Platelet’s Behavior on Nanostructured Superhydrophobic Surface

Zhou

Yang

Xia

et al. 2008

JNanoR

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Abstract. Regular arrays of micro-pillars and nano-grooves structures on the silicon wafer are fabricated by using soft lithography, and the three dimension morphology of textured surface is observed by using scanning electron microscopy (SEM) and atomic force microscope (AFM). The static water contact angles are measured by using contact angle meter to characterize the wettabilities of these surfaces. To investigate how the presence of topography and the variations of wettability affect the haemocompatibility of textured surface contacted with blood, different patterned surfaces are designed and fabricated, and blood platelet adhesion test is carried out on these surfaces. The adhesion and coagulation of platelets are inspected by scanning electron microscopy (SEM). Experimental data presented in this paper indicate that different surface roughness and wettability are the important factors for blood platelet adhesion. The amount of adsorbed blood platelet is low on textured surfaces, compared with that on the flat surface. Especially, there is no coagulation and activation on the surface with nanometer grooves. That is to say, the superhydrophobic surface is apt to decrease blood platelet adhesion. The study suggests that surface with suitable wettabililty and textured structures exhibits superior blood compatibility.

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Platelet adhesion and protein adsorption on silicone rubber surface by ozone-induced grafted polymerization with carboxybetaine monomer

Cited by 62 publications

References 25 publications

Anti‐Biofouling Properties of Polymers with a Carboxybetaine Moiety

Anti‐Biofouling Properties of Polymers with a Carboxybetaine Moiety

Structures and Synthesis of Zwitterionic Polymers

Blood Platelet’s Behavior on Nanostructured Superhydrophobic Surface

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