Platelet aggregation and fatty acid composition of platelets in type 1 diabetes mellitus

Myrup, B.; Bregengaard, Claus; Petersen, Laurids R.; Winther, Kaj

doi:10.1016/0009-8981(91)90236-6

Cited by 10 publications

(6 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, hyperaggregability of platelets occurring in acute pancreatitis coincides with increases in serum activity of the serine protease, thrombin. 34 Another possibility is a change in the plasma membrane lipid composition, as is proposed for enhanced aggregability in human patients with diabetes mellitus and some cardiovascular disorders.3", 35 Young platelets have increased activity compared with older platelet^. '^ Shortened platelet life span has been documented in dogs with various malignancies, and it is possible simply that platelet age is responsi-ble for our observations.38 It is unclear if platelet hyperaggregability results directly (tumor-derived product), or indirectly (secondary changes induced by the neoplasm).…”

Section: Discussionmentioning

confidence: 86%

Platelet Hyperfunction in Dogs With Malignancies

McNiel

Ogilvie

Fettman

et al. 1997

Veterinary Internal Medicne

View full text Add to dashboard Cite

In vitro platelet aggregometry was performed on whole blood samples from 59 dogs with malignancies and 24 control dogs. Three reagents were used for the aggregation studies: collagen, arachidonic acid, and adenosine diphosphate (ADP). The parameters measured to evaluate response to collagen included delay in the aggregation response, slope of the aggregation curve, maximum aggregation, and adenosine triphosphate (ATP) secretion. The platelets of dogs with malignancies exhibited significantly ( P < .05) shorter delays in the aggregation response, higher maximum aggregation, and higher ATP secretion when compared to control dogs. For the weaker reagents, ADP and ormal hemostasis results from coordinated interaction N of vascular endothelium, the coagulation cascade, and platelets. A disruption of any aspect of this system may result in the tendency to bleed or clot inappropriately. Altered hemostasis is well recognized in the cancer patient.'-' Conditions such as disseminated intravascular coagulation, bleeding diatheses, and thromboembolism have been frequently described as complications of malignancy. Coagulation parameters have been demonstrated to be altered in the cancer Previous work evaluating the hemostatic system has focused on the coagulation cascade and on platelet numbers, with little attention given to platelet fun~tion.'.~ Altered platelet function, however, may play an important role in the development of coagulation disorders and the metastatic process.Human cancer patients frequently are in a hypercoagulable state, which may predispose them to thromboembolic disease; this condition often goes unrecognized in small animal patients.2 The role of platelets in creating a hypercoagulable state and subsequent thromboembolism is poorly understood.In addition to their role in hemostasis, platelets have been demonstrated to be important in the development of metastas~s . ' ,~. '~ Metastasis is a complex cascade of events, and platelets may participate in this process in a number of ways. Platelets may aid in the survival of tumor cells in circulation, their attachment at a distant capillary bed, their invasion into

show abstract

Section: Discussionmentioning

confidence: 86%

Platelet Hyperfunction in Dogs With Malignancies

McNiel

Ogilvie

Fettman

et al. 1997

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

“…Increase in serum factors inducing platelet aggregation has been seen in acute pancreatitis in dogs, and changes in platelet plasma membrane lipid composition have been suggested to increase aggregability in humans with diabetes mellitus and some cardiovascular disorders. [40][41][42] A shortened platelet life span can explain findings of platelet hyperaggregability because young platelets are more active than older platelets. 43 The high prevalence of macrothrombocytosis could indicate an increased thrombocytopoiesis in CKCS, 21 but in this study, an increased platelet aggregation was found only in CKCS with Ͼ100,000 platelets/Lwhich are not the ones that usually have macrothrombocytosis.…”

Section: Discussionmentioning

confidence: 99%

Increased Platelet Aggregation Response in Cavalier King Charles Spaniels with Mitral Valve Prolapse

Olsen

Kristensen

Häggström

et al. 2001

Veterinary Internal Medicne

View full text Add to dashboard Cite

Mitral valve prolapse (MVP) is a fundamental feature of myxomatous mitral valve disease in the dog. In humans, primary MVP is associated with increased platelet reactivity. In Cavalier King Charles Spaniels (CKCS), a breed predisposed to myxomatous mitral valve disease, there is a high prevalence of hypomagnesemia and platelet anomalies, such as thrombocytopenia and macrothrombocytosis. The objective of this study was to evaluate platelet aggregation responses in CKCS and to determine the relationship between the platelet aggregation response and serum magnesium concentration, MVP, mitral regurgitation (MR), and platelet count. In 19 CKCS with MVP and 7 control dogs (not CKCS), the platelet aggregation response to 3 different agonists was compared. The CKCS with >100,000 platelets/microL (n = 10) had a significantly higher maximum aggregation response with regard to all tested agonists than the CKCS with <100,000 platelets/microL (n = 9) and control dogs (n = 7). The CKCS with <100,000 platelets/microL had a platelet aggregation response similar to the control dogs. There was no correlation between degree of MVP and platelet aggregation response. Platelet diameter increased (P = .006) and serum magnesium concentration decreased (P = .04) with lower platelet concentration. In conclusion, CKCS with MVP appeared to separate into 2 groups--1 group with <100,000 platelets/microL, normal platelet aggregation, low serum magnesium concentration, and enlarged platelets, and another group with >100,000 platelets/microL, increased platelet aggregation, and normal serum magnesium concentration and platelet size.

show abstract

“…In addition, participants were not prohibited from smoking during the day of examination, something that may have influenced our measured NEFA concentrations (44). Finally, we have no information on platelet levels, which are also shown to be affected by NEFA variation (45).…”

Section: Discussionmentioning

confidence: 99%

Nonesterified Fatty Acids and Cardiovascular Mortality in Elderly Men with CKD

Xiong

Huang

et al. 2015

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

Background and objectives Although nonesterified fatty acids (NEFAs) are essential as energy substrate for the myocardium, an excess of circulating NEFAs can be harmful. This study aimed to assess plausible relationships between serum NEFA and mortality due to cardiovascular disease (CVD) in individuals with CKD.Design, setting, participants, & measurements This was a prospective cohort study from the third examination cycle of the Uppsala Longitudinal Study of Adult Men, a population-based survey of 1221 elderly men aged 70-71 years residing in Uppsala, Sweden. Data collection took place during 1991-1995. All participants had measures of kidney function; this study investigated 623 (51.7%) of these patients with manifest CKD (defined as either eGFR,60 ml/min per 1.73 m 2 or urine albumin excretion rate $20 mg/min). Follow-up for mortality was done from examination date until death or December 31, 2007. After a median follow-up of 14 years (interquartile range, 8-16.8), associations of NEFAs with mortality (related to all causes, CVD, ischemic heart disease [IHD], or acute myocardial infarction) were ascertained.Results The median serum NEFA was 14.1 mg/dl (interquartile range, 11.3-17.8). No association was found with measures of kidney function. Diabetes and serum triglycerides were the only multivariate correlates of NEFA. During follow-up, 453 participants died, of which 209 deaths were due to CVD, including 88 IHD deaths, with 41 attributed to acute myocardial infarction (AMI). In fully adjusted covariates, serum NEFA was an independent risk factor for all-cause mortality (hazard ratio [HR] per log 2 increase, 1.22; 95% confidence interval [95% CI], 1.00 to 1.48) and CVD-related death (HR, 1.51; 95% CI, 1.15 to 1.99), including both IHD (HR, 1.51; 95% CI, 1.00 to 2.32) and AMI mortality (HR, 2.08; 95% CI, 1.09 to 3.98).Conclusions Elevated serum NEFA associated with CVD mortality, and particularly with mortality due to AMI, in a homogeneous population of older men with moderate CKD.

show abstract

Platelet aggregation and fatty acid composition of platelets in type 1 diabetes mellitus

Cited by 10 publications

References 21 publications

Platelet Hyperfunction in Dogs With Malignancies

Platelet Hyperfunction in Dogs With Malignancies

Increased Platelet Aggregation Response in Cavalier King Charles Spaniels with Mitral Valve Prolapse

Nonesterified Fatty Acids and Cardiovascular Mortality in Elderly Men with CKD

Contact Info

Product

Resources

About