Platelet Aggregation in Diabetic Retinopathy

Creter, D; Pavlotzky, Fira; Savir, H

doi:10.1159/000207695

Cited by 9 publications

(2 citation statements)

References 7 publications

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“…No sta tistically significant increased sensitivity to ADP was found by us in the normal group as compared with the diabetic retinopathy patients [4], The present study demonstrates that ADP-induced aggregation in the pres ence of vitamin E was inhibited. This effect was not obtained when ADP was substitut ed by arachidonic acid.…”

Section: Discussioncontrasting

confidence: 42%

Effect of Vitamin E on Platelet Aggregation in Diabetic Retinopathy

Creter¹,

Pavlotzky²,

Savir³

1979

Acta Haematol

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The effect of vitamin E on platelet aggregation was investigated in a group of 10 patients with diabetic retinopathy. Adenosine diphosphate induced platelet aggregation was inhibited in the patients’ group as well as in the controls in the presence of vitamin E. An increased platelet aggregation was obtained with arachidonic acid in both groups when platelet-rich plasma was incubated prior with vitamin E. The clot retraction inhibition test parallels the findings of aggregation obtained with the platelet aggregation meter.

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Section: Discussioncontrasting

confidence: 42%

Effect of Vitamin E on Platelet Aggregation in Diabetic Retinopathy

Creter¹,

Pavlotzky²,

Savir³

1979

Acta Haematol

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“…Therefore, by stopping argatroban as soon as the dissection of the fibrovascular membranes is completed, there is little risk of postoperative bleeding and clotting can be safely controlled [ 13 ]. A worsening of PDR with increased platelet aggregation has also been reported [ 14 , 15 ]. Hence, although HIT activity is suppressed by anticoagulant drugs, careful follow-up is required to observe whether or not PDR is worsened by HIT.…”

Section: Discussionmentioning

confidence: 93%

Vitrectomy for Proliferative Diabetic Retinopathy in a Patient with Heparin-Induced Thrombocytopenia

Fujii¹,

Akashi²,

Morishita³

et al. 2016

Case Rep Ophthalmol

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Introduction: In this study, we report a case of proliferative diabetic retinopathy in a patient with heparin-induced thrombocytopenia (HIT) in whom vitrectomy was performed with good results. Case: A 57-year-old man presented with a chief complaint of decreased visual acuity (VA) in the left eye. Corrected VA of the left eye was 0.03, and ophthalmic examination showed fibrovascular membranes along the vascular arcade and a combined rhegmatogenous-traction retinal detachment with a macular hole. The patient began hemodialysis for diabetic nephropathy in March 2014; thrombocytopenia developed after dialysis was started, and HIT was diagnosed after further evaluation. Argatroban hydrate was being used during dialysis. Treatment was switched from warfarin to argatroban hydrate 6 days prior to vitrectomy being performed on the patient's left eye. Although there was bleeding with somewhat difficult hemostasis during the intraoperative treatment of the fibrovascular membranes, surgery was completed without complications and the postoperative course was good. Discussion: Vitrectomy was performed with good results in this patient with HIT. Treatment with argatroban hydrate during surgery enabled surgery without the danger of intraoperative clotting.

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