Platelet Aggregation Inhibitors in a Bhutanese Medicinal Plant, Shug Chher.

Kagawa, Kiyomi; Tokura, Katsuya; Uchida, Kiyohisa; Kakushi, Hisato; Shike, Tsutomu; Kikuchi, Junko; Nakai, Hiroshi; Dorji, Pema; Subedi, Loknath

doi:10.1248/cpb.41.1604

Cited by 25 publications

(19 citation statements)

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“…By comparing their physical and spectroscopic data with those reported in the literatures, the known compounds 3-9 were determined to be 3a,13b-dihydroxylabda-8(17),14-diene (3) (Kagawa et al, 1993), acetosyringenin or 4-hydroxyl-3,5-dimethoxybenzaldehyde (4) (Pettit et al, 2009), cerevisterol or (22E,24R)-3b,5a,6b-trihydroxyl-ergosta-7,22-diene (5) , 3b-hydroxyl-5a,8a-epidioxy-ergosta-6,22-diene (6) (Yue et al, 2001), ergosterol endoperoxide (7) (Yue et al, 2001), stigmast-3b,7b-dihydroxyl-5-ene (8) (Du and Shen, 2006;Hou et al, 2002), and stigmast-3b,7a-dihydroxyl-5-ene (9) (Li et al, 2005).…”

Section: Resultsmentioning

confidence: 99%

Caryolane-type sesquiterpenes from Cirsium souliei

Jin

et al. 2014

Phytochemistry Letters

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Section: Resultsmentioning

confidence: 99%

Caryolane-type sesquiterpenes from Cirsium souliei

Jin

et al. 2014

Phytochemistry Letters

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“…(). Biformene could also inhibit platelet aggregation and in turn blood coagulation (Kagawa et al ., ). In addition, Belitz et al .…”

Section: Resultsmentioning

confidence: 99%

Characterization of secondary volatile profiles in Nigella sativa seeds from two different origins using accelerated solvent extraction and gas chromatography‐mass spectrometry

El‐Aty

Cho³

et al. 2012

Biomedical Chromatography

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The extraction and identification of bioactive compounds from herbs is of great interest. In this study, accelerated solvent extraction (ASE) technique was used to analyze the secondary volatile profiles in Nigella sativa seeds obtained from two different origins, Egypt and Bangladesh. The main extraction parameters, including extraction temperature, pressure and static extraction time, were investigated and optimized. Identification and quantification of the major constituents in nonpolar extracts (hexane) were achieved by means of GC-FID/GC-MS analysis with external standards. The two seeds showed a similar variety of chemical composition; however, the secondary volatiles profile of Bangladesh seed was higher than that of the Egyptian seed. A total of 25 compounds were identified from the ASE extract under the following optimum extraction conditions: 100°C, 1500 psi and 5 min, for extraction temperature, pressure and static time, respectively. The proposed technique can be used for the characterization of N. sativa varieties or cultivars.

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“…hexane extract from leaves Vero: African green monkey kidney cell line Supporting information available online at http://www.thieme-connect.de/ejournals/toc/plantamedica The Juniperus genus (Cupressaceae family) is a very promising source of bioactive compounds since several Juniperus species are used in traditional medicine as antitussive [1], [2] and antifertility agents [3], as remedies for tuberculosis [4], colds, dysentery, leukorrhoea, rheumatic arthritis [5], fever and as an insect repellent [6], [7]. They are mainly a source of sesquiterpenes, diterpenes and lignans, some of which have very promising biological activities [8].…”

Section: Abmentioning

confidence: 99%

Cytotoxic Activity of Diterpenes and Extracts ofJuniperus brevifolia

et al. 2008

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The hexane, dichloromethane, acetone and ethanol extracts of the leaves, bark and wood of Juniperus brevifolia were subjected to screening against human tumour cells lines from the cervix (HeLa) and larynx (Hep-2) in two different stages of the cell cycle. The dichloromethane and the chloroform-soluble portions of the acetone extracts of the leaves were active against both tumour cell lines. Chemical investigation of one of the most active extracts (dichloromethane extract from leaves) by preparative chromatography afforded compounds 1-10. Among these, compounds 1-3 were isolated for the first time from the Juniperus genus (18-hydroxyferruginol, 6,7-dehydrototarol and 7alpha-hydroxytotarol) while 4 and 5 are rare as natural products corresponding to (E)- and (Z)-isomers of 8alpha-hydroxy-labda-13(16),14-dien-19-yl-coumarate, respectively. The structures of all compounds were established based on various spectral data. The cytotoxic activity was evaluated for the first time for compounds 1-5 against HeLa and Vero cell lines in lag and log phases of growth. Compound 5 was shown to be active and selective to HeLa in the log phase.

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Platelet Aggregation Inhibitors in a Bhutanese Medicinal Plant, Shug Chher.

Cited by 25 publications

References 0 publications

Caryolane-type sesquiterpenes from Cirsium souliei

Caryolane-type sesquiterpenes from Cirsium souliei

Characterization of secondary volatile profiles in Nigella sativa seeds from two different origins using accelerated solvent extraction and gas chromatography‐mass spectrometry

Cytotoxic Activity of Diterpenes and Extracts ofJuniperus brevifolia

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