Platelet and red blood cell interactions and their role in rheumatoid arthritis

Olumuyiwa-Akeredolu, Oore-ofe O.; Pretorius, Etheresia

doi:10.1007/s00296-015-3300-7

Cited by 38 publications

(29 citation statements)

References 97 publications

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“…30) Meanwhile, the inflammation in arthritis synovium also initiates neovascularization, which would accelerate the dysfunction of joint, and eventually contribute to its deformity, stiffness, and function loss. 31) In addition, RA is a chronic disease, shown as alternatively attack and remission. At present, the disability of RA is up to 60-70%.…”

Section: Discussionmentioning

confidence: 99%

Crocin reduces the inflammation response in rheumatoid arthritis

Jiang

Zhu

2017

Bioscience, Biotechnology, and Biochemistry

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This study is to determine the role and mechanism of crocin in rheumatoid arthritis (RA). Totally 60 Wistar SD rats were randomly divided into control group, RA model group, methotrexate group, crocin high dose, middle dose, and low dose groups. The paw swelling degree, arthritis score, thymus and spleen index, the mRNA and protein levels of iNOS, and the serum content of TNF-α, IL-1β, and IL-6 were evaluated. Crocin treatment significantly alleviated the paw swelling of RA rats. The arthritis score in crocin treatment groups was significantly lower than that in RA model group. Additionally, the thymus index, but not the spleen index, declined remarkably in crocin treatment groups than in RA model group. Besides, crocin administration significantly reduced the iNOS production and the serum content of TNF-α, IL-1β, and IL-6. Crocin may exert potent anti-RA effects through inhibiting cytokine.

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Section: Discussionmentioning

confidence: 99%

Crocin reduces the inflammation response in rheumatoid arthritis

Jiang

Zhu

2017

Bioscience, Biotechnology, and Biochemistry

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“…inflammation that is reflected in a profile of increased inflammatory cytokines (129). In addition, ineffective erythropoiesis in HbE/b-thal has been attributed to overactive EPO-mediated signal transduction correlated with high levels of ROS emanating from an increased oxidative metabolism (100) and also correlated with increased levels of specific inflammatory cytokines (181).…”

Section: Fig 2 Hbe Acts As a Bmentioning

confidence: 99%

HbE/β-Thalassemia and Oxidative Stress: The Key to Pathophysiological Mechanisms and Novel Therapeutics

Hirsch

Sibmooh

Fucharoen

et al. 2017

Antioxidants & Redox Signaling

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Significance: Oxidative stress and generation of free radicals are fundamental in initiating pathophysiological mechanisms leading to an inflammatory cascade resulting in high rates of morbidity and death from many inherited point mutation-derived hemoglobinopathies. Hemoglobin (Hb)E is the most common point mutation worldwide. The b E -globin gene is found in greatest frequency in Southeast Asia, including Thailand, Malaysia, Indonesia, Vietnam, Cambodia, and Laos. With the wave of worldwide migration, it is entering the gene pool of diverse populations with greater consequences than expected. Critical Issues: While HbE by itself presents as a mild anemia and a single gene for b-thalassemia is not serious, it remains unexplained why HbE/b-thalassemia (HbE/b-thal) is a grave disease with high morbidity and mortality. Patients often exhibit defective physical development, severe chronic anemia, and often die of cardiovascular disease and severe infections. Recent Advances: This article presents an overview of HbE/b-thal disease with an emphasis on new findings pointing to pathophysiological mechanisms derived from and initiated by the dysfunctional property of HbE as a reduced nitrite reductase concomitant with excess a-chains exacerbating unstable HbE, leading to a combination of nitric oxide imbalance, oxidative stress, and proinflammatory events. Future Directions: Additionally, we present new therapeutic strategies that are based on the emerging molecular-level understanding of the pathophysiology of this and other hemoglobinopathies. These strategies are designed to short-circuit the inflammatory cascade leading to devastating chronic morbidity and fatal consequences. Antioxid. Redox Signal. 26,[794][795][796][797][798][799][800][801][802][803][804][805][806][807][808][809][810][811][812][813]

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“…Osteoarthritis (OA), fibromyalgia (FM), rheumatoid arthritis (RA) and spondyloarthritis (SpA) are among the most predominant rheumatic diseases; articular pain is common in all of them, and laboratory tests are used for their differential diagnoses, specifically, inflammation biomarkers and auto‐antibodies determination. In autoimmune diseases evidence exists revealing an association between red blood cell distribution width (RDW) and inflammatory activity, as reported in systemic lupus erythematosus, RA, SpA, Sjögren's syndrome and Behçet's disease …”

Section: Introductionmentioning

confidence: 98%