Platelet and Red Blood Cell Indices in Patients with Panic Disorder: A Receiver Operating Characteristic Analysis

Abstract

Objective Panic disorder (PD) is associated with changes in platelet and red blood cell (RBC) indices. However, the diagnostic or predictive value of these indices is unknown. This study assessed the diagnostic and discriminating value of platelet and RBC indices in patients with PD. Materials and Methods In this cross-sectional study including patients with PD (n = 98) and healthy controls (n = 102), we compared the following blood indices: mean platelet volume (MPV), platelet distribution width (PDW), and RBC distribution width (RDW). The receiver operating characteristic (ROC) curve was used to calculate the area under the ROC curve (AUC), sensitivity, specificity, and likelihood ratio for the platelet and RBC indices. Results Statistically significant increase in PDW (17.01 ± 0.91 vs. 14.8 ± 2.06; p < 0.0001) and RDW (16.56 ± 2.32 vs. 15.12 ± 2.43; p < 0.0001) levels were observed in patients with PD. PDW and mean corpuscular hemoglobin concentration had larger AUC (0.89 and 0.74, respectively) and Youden’s index (0.65 and 0.39, respectively), indicating their higher predictive capacity as well as higher sensitivity in discriminating patients with PD from healthy controls. Conclusion PDW can be considered a “good” diagnostic or predictive marker in patients with PD.

Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities

“…Indeed, serotonergic agents have been reported to relieve panic symptoms [ 307 ]. Some of these studies reported evidence of increased MPV in PanDis patients vs. healthy controls [ 177 , 184 , 185 ], while others reported significant associations with an opposite direction of effect [ 168 , 169 , 178 ]. Those works which analyzed PDW reported higher values for cases [ 168 , 169 , 185 ], except for one detecting no significant differences [ 178 ].…”

“…Some of these studies reported evidence of increased MPV in PanDis patients vs. healthy controls [ 177 , 184 , 185 ], while others reported significant associations with an opposite direction of effect [ 168 , 169 , 178 ]. Those works which analyzed PDW reported higher values for cases [ 168 , 169 , 185 ], except for one detecting no significant differences [ 178 ]. Likewise, for Plt, contrasting results were reported: higher count in PanDis patients [ 168 , 169 ] vs. no significant difference between cases and controls in [ 177 , 178 ].…”

“…Those works which analyzed PDW reported higher values for cases [ 168 , 169 , 185 ], except for one detecting no significant differences [ 178 ]. Likewise, for Plt, contrasting results were reported: higher count in PanDis patients [ 168 , 169 ] vs. no significant difference between cases and controls in [ 177 , 178 ].…”

“…A summary of shared associated platelet markers among MDD and its comorbidities is reported in Table 2. [146], PanDis [168,169], GAD [146], ASD [170], ADHD [171,172] ↓ in GAD [173] No association with MDD [145], Depressive Symptoms with MI [174], AD [175], PD [175,176], PanDis [177,178], ADHD [171,172,179,180] MPV ↑ in MDD [144][145][146][147], Depressive Symptoms [150], post-Ischemic Stroke depression [181,182], AD [175,183], PD [175], PanDis [177,184,185], GAD [146,173], ADHD [171,179,180,186] ↓ in VaD patients [187] and in AD [187,188], MCI [188], PanDis [168,169,178] Negative correlation with PD progression stage (Hoehn and Yahr score…”

Neutrophil to Lymphocyte Ratio in Generalized Anxiety Disorder

“…Şizofreni (1), bipolar bozukluk (BB) (3), major depresif bozukluk (MDB) (4) ve madde kullanım bozukluğu (MKB) (5,6), TKS ile ilişkisi sıklıkla araştırılmış psikiyatrik bozukluklardır. Anksiyete bileşeni olan psikiyatrik bozukluklardan panik bozukluk (PB) (7) ve obsesifkompulsif bozukluk (OKB) (8)'deki TKS verilerine de literatür vasıtasıyla ulaşılmaktadır.…”