Platelet concentrates: Regenerating the lost tissues

Agarwal, Kriti; Agarwal, Kanika; Kumar, Nishant

doi:10.4103/0975-7406.120074

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…The principal mechanisms mediating chemotherapy resistance are enhanced proliferation of cancer cells through activation of the MAPK signalling pathway, activation of anti-apoptotic proteins, or phenotypic conversion in cancer cells through the epithelial-mesenchymal transition, all of which could potentially be affected by platelets. The platelet secretome is rich in growth factors and is used clinically to enhance tissue regeneration [ 103 ]. During the wound healing process, platelets display a pro-proliferative role through the secretion of various growth factors.…”

Section: The Role Of Platelets In Chemotherapy Resistancementioning

confidence: 99%

Targeting Platelets for the Treatment of Cancer

Elaskalani

Berndt

Falasca

et al. 2017

Cancers

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The majority of cancer-associated mortality results from the ability of tumour cells to metastasise leading to multifunctional organ failure and death. Disseminated tumour cells in the blood circulation are faced with major challenges such as rheological shear stresses and cell-mediated cytotoxicity mediated by natural killer cells. Nevertheless, circulating tumour cells with metastatic ability appear equipped to exploit host cells to aid their survival. Despite the long interest in targeting tumour-associated host cells such as platelets for cancer treatment, the clinical benefit of this strategy is still under question. In this review, we provide a summary of the latest mechanistic and clinical evidence to evaluate the validity of targeting platelets in cancer.

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Section: The Role Of Platelets In Chemotherapy Resistancementioning

confidence: 99%

Targeting Platelets for the Treatment of Cancer

Elaskalani

Berndt

Falasca

et al. 2017

Cancers

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“…These preparations contain autologous platelets, several different growth factors (such as PDGF, TGF‐β1, VEGF, IGF‐1, TNF‐α) as well as other cytokines involved in the key processes of tissue regeneration including cell proliferation and differentiation, extracellular matrix synthesis, chemotaxis, and angiogenesis (Anitua et al, ; Martínez, Smith, & Palma Alvarado, ; Schär, Diaz‐Romero, Kohl, Zumstein, & Nesic, ). Growth factors and cytokines are contained in platelet secretory granules and they are released from activated platelets, so promoting healing in both soft and hard tissues (Agarwal, Agarwal, & Kumar, ; Naik, Karunakar, Jayadev, & Marshal, ; Oryan, Alidadi, & Moshiri, ).…”

Section: Introductionmentioning

confidence: 99%

How the different material and shape of the blood collection tube influences the Concentrated Growth Factors production

Bonazza

Borsani

Buffoli

et al. 2016

Microscopy Res & Technique

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Platelet concentrates, such as Concentrated Growth Factors (CGF), are autologous preparations obtained from the patient's own blood and rich in platelets, growth factors and cytokines involved in the key processes of tissue regeneration. These autologous concentrates differ in the way of preparation and also in the content of platelets, growth factors and leucocytes, as well as in the fibrin network architecture. So it is difficult to have a standardized product. The aim of the present study was to evaluate how the use of test tubes of different material, for blood collection, could influence the CGF production. Three different test tubes were used and the obtained CGFs were subjected to histomorphological and immunohistochemical analyses. Results showed that the tube material and shape influenced the CGF composition. In fact, according to the type of tube used, the obtained CGFs showed differences in morphology, in the fibrin network architecture and in blood cell localization and distribution.

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Platelet concentrates: Regenerating the lost tissues

Cited by 2 publications

References 4 publications

Targeting Platelets for the Treatment of Cancer

Targeting Platelets for the Treatment of Cancer

How the different material and shape of the blood collection tube influences the Concentrated Growth Factors production

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