Platelet count and parameters determined by the Bayer ADVIA^TM 120 in reference subjects and patients

Abstract

In order to study the behaviour of traditional and new platelet parameters determined by the ADVIA 120 Hematology System, five hundred samples from reference subjects, divided for sex and age, were processed. Significant variations on the basis of sex and age were found. Reference ranges as 95% confidence limits were therefore calculated for each age class, and platelet parameters proved to have specific variations during lifetime. Moreover, one hundred samples from thrombocytopenic patients were processed by the ADVIA 120 System. When compared with those of reference subjects matched for sex and age, all platelet parameters, except mean platelet component (MPC), showed significant differences.

Platelet count, mean platelet volume, platelet distribution width, and plateletcrit do not correlate with optical platelet aggegation responses in healthy volunteers

“…However, we have evaluated the correlation between total platelet mass and platelet aggregation and we could not find any correlation in our study. Another index of platelet mass in the sample is PCT and PCT reflects the volume occupied by platelets in blood as percentage [11].…”

“…There is now much interest in developing methods and instruments for an accurate platelet count and the determination of platelet parameters in various pathologies [11]. Recent advances in automated blood cell analysers have made it possible to measure blood cell parameters automatically.…”

Measurement of the Ultrasound Attenuation and Dispersion in Whole Human Blood and its Components From 0–70 MHz

“…Published normal ranges for cell counts vary slightly with patient population and method of analysis. Normal ranges in a Caucasian population demonstrate a red cell count of 4:3225:66310 12 cells/L in men and 3:8824:99310 12 cells/L in women, a leukocyte count of 3:729:5310 9 cells/L in men and 3:9211:1310 9 cells/L in women (Bain 2006) and a platelet count of 1652396310 9 cells/L (Giacomini et al 2001). The proportion of the total volume of whole blood that red blood cells occupy (commonly called the packed cell volume or haematocrit) is normally in the range 39%-51% for males and 36%-48% for females Tefferi 2000, 2001).…”

Increased Platelet Cholesterol and Decreased Percentage Volume of Platelets as a Secondary Risk Factor for Coronary Artery Disease

“…Measurement of platelet activation indices in various platelet disorders is becoming increasingly popular because of the recent advances in automated blood cell counters [16,17] .…”