Platelet count and plateletcrit are associated with an increased risk of venous thrombosis in females. Results from the RETROVE study

Vázquez-Santiago, Miquel; Vilalta, N.; Ziyatdinov, Andrey; Cuevas, Biel; Macho, Raquel; Pujol-Moix, Núria; Carrasco, Marina; Mateo, José; Fontcuberta, Jordi; Soria, José Manuel Nieto; Souto, Juan Carlos

doi:10.1016/j.thromres.2017.07.022

Cited by 25 publications

(24 citation statements)

References 8 publications

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“…Several studies have considered that MPV, PCT, PDW, and PLCR are biomarkers of platelet activation (9), therefore our results suggest that, compared with platelet activation, platelet quantity is more closely associated with body fat. These findings were supported by a recent study that found that platelet quantity was closely associated with venous thrombosis (10). However, no such associations were observed in participants with CVD in our study.…”

Section: Discussionsupporting

confidence: 90%

“…In previous studies, increased PLT has been found to be associated with thrombosis , metabolic syndrome , and CVD . Our results suggested that patients with excessive central fat accumulation might have an elevated PLT level, which could increase the risk of platelet‐related diseases.…”

Section: Discussionsupporting

confidence: 59%

“…Platelet indices include platelet count (PLT), mean platelet volume (MPV), plateletcrit (PCT), platelet distribution width (PDW), and platelet large cell ratio (PLCR) . These indices have been found to have prognostic and diagnostic values in certain diseases, including CVD and venous thrombosis . However, the clinical significance, reference values, and usefulness of these indices are still under investigation .…”

Section: Introductionmentioning

confidence: 99%

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Associations of Platelet Indices with Body Fat Mass and Fat Distribution

Han

Gan

Wang

et al. 2018

Obesity

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Objective This study was undertaken to investigate the associations of platelet indices with body fat, including body fat mass and fat distribution. Methods A total of 3,327 individuals aged 18 to 80 were enrolled. Body fat was assessed by dual‐energy x‐ray absorptiometry. Blood samples were collected to measure platelet indices (platelet count [PLT], plateletcrit [PCT], mean platelet volume, platelet distribution width, and platelet large cell ratio). Adjusted multivariate linear regression models were used to identify the associations of platelet indices with body fat. Results PLT was positively associated with BMI, waist circumference, waist‐hip ratio, total fat mass percentage, trunk fat mass percentage, android fat mass percentage, and android to gynoid fat ratio but negatively associated with gynoid fat mass percentage, total lean mass percentage, and skeletal muscle mass index. Similar associations were found between PCT and body fat. However, no significant associations were found between the other three platelet indices and body fat. Conclusions Both PLT and PCT were associated with body fat, and the associations depended on fat location. Because PCT is mainly influenced by PLT, these associations suggest that platelet quantity is more closely related to body fat mass and fat distribution.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

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Associations of Platelet Indices with Body Fat Mass and Fat Distribution

Han

Gan

Wang

et al. 2018

Obesity

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“…Both MPV and PCT were found to be higher in saphenous vein graft disease after by-pass surgery (16) and were found to be associated with short-term outcomes of ischemic stroke (17). Moreover, PCT was related to increased venous thromboembolism risk in females (18). Impact of PCT was studied in high thrombus burden clinical scenario in two separate studies (8,9).…”

Section: Discussionmentioning

confidence: 99%

A Simple Independent Predictor of in-Hospital and Long-Term Outcomes in Patients with STEMI: Plateletcrit

Keskin¹,

Kaya²,

İpek³

et al. 2020

hamidiyemedj

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Background: Platelet mass, namely plateletcrit (PCT), is the total platelet mass which is calculated by multiplying platelet count with mean platelet volume. There are several studies revealing that higher PCT is associated with higher mortality in patients with myocardial infarction. We aimed to investigate the association of high PCT levels and in-hospital and long-term outcomes of ST-segment elevation myocardial infarction (STEMI) in a high-volume center. Materials and Methods: A total of 2.415 patients were eligible to the study. The study population was divided into three tertiles according to the PCT values starting from the lowest to highest level (T1,T2,T3). In-hospital and long-term outcomes were compared between these tertiles. Results: In-hospital acute kidney injury, recurrent myocardial infarction, target lesion revascularization, stent thrombosis, cardiogenic shock and all-cause mortality rates were significantly higher in T3 compared to other tertiles. Besides, the rate of long-term all-cause mortality was higher in T3 than in the other tertiles. In the multivariable regression analysis, high PCT was found as an independent predictor for mortality. Conclusion: The current study demonstrated the higher in-hospital and long-term unfavorable outcomes in patients with STEMI, who had a high PCT.

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“…PCT is calculated as the MPV multiplied by the PLT. It has been identified that an elevated PCT is associated with coronary artery disease and an increased risk of venous thrombosis (8,9). The PDW is one of the platelet volume indicators, reflecting the average change in platelet volume (10).…”

Section: Introductionmentioning

confidence: 99%

Prognostic evaluation of resectable colorectal cancer using platelet‑associated indicators

Qian

et al. 2019

Oncol Lett

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Colorectal cancer (CRC) represents the third most common malignancy worldwide. The aim of the present study was to investigate the predictive values of platelet-associated indicators, including platelet count (PLT), plateletcrit (PCT), mean platelet volume (MPV) and platelet distribution width (PDW) in patients with resectable CRC. The current retrospective study included 153 patients who were pathologically diagnosed with resectable CRC. The patients were divided into two groups according to the median value of PLT, PCT, MPV or PDW. To evaluate the changes in PLT, PCT, MPV and PDW following resection and adjuvant chemotherapy, the concept of post-/pre-treatment PLT, PCT, MPV and PDW ratios was introduced, where <1 indicated decreased PLT, PCT, MPV and PDW values after treatment, and where ≥1 suggested stable or increased values. It was revealed that a low MPV prior to treatment correlated with a higher tumor stage. Surgery significantly decreased MPV, but had no impact on PLT, PCT or PDW. Adjuvant chemotherapy significantly decreased PLT and PCT, increased MPV and had no effect on PDW. After the whole course of treatment (surgery combined with adjuvant chemotherapy), PLT, PCT and PDW were significantly decreased. Kaplan-Meier plots illustrated that patients with a post-/pre-treatment MPV ratio <1 had poorer overall survival (OS), whereas the post-/pre-treatment ratios for PLT, PCT and PDW did not correlate with patient outcome. Multivariate Cox regression analysis revealed that sex, tumor size and the post-/pre-treatment MPV ratio were prognostic factors for OS. Therefore, the present results may suggest MPV as a potential prognostic factor in resectable CRC.

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Platelet count and plateletcrit are associated with an increased risk of venous thrombosis in females. Results from the RETROVE study

Cited by 25 publications

References 8 publications

Associations of Platelet Indices with Body Fat Mass and Fat Distribution

Associations of Platelet Indices with Body Fat Mass and Fat Distribution

A Simple Independent Predictor of in-Hospital and Long-Term Outcomes in Patients with STEMI: Plateletcrit

Prognostic evaluation of resectable colorectal cancer using platelet‑associated indicators

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