Platelet dense granule secretion in adolescents with conduct disorder and substance abuse: Preliminary evidence for variation in signal transduction

Moss, Howard B.; Yao, Jeffrey

doi:10.1016/0006-3223(95)00521-8

Cited by 3 publications

(2 citation statements)

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“…As 5‐HT also serves an analogous agonist function to ADP, and the ADP response may provide an index of the B max of platelet 5‐HT 2A receptors, researchers have manipulated ADP to determine platelet response. In the first such study, 66 adolescent boys with comorbid CD and psychoactive substance use disorder (PSUD), and 40 HC boys, had blood assays evaluated for the effect of various agonists such as ADP. Compared to the controls, platelet samples from adolescents with CD + PSUD showed less ATP secretion in response to ADP stimulation.…”

Section: Literature Reviewmentioning

confidence: 99%

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Serotonin and aggressive behaviour in children and adolescents: a systematic review

Runions

Morandini

Rao

et al. 2019

Acta Psychiatr Scand

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aggressive behaviour in children and adolescents: a systematic review.Objective: The role of serotonin (5-HT) in human aggression has been the subject of a large number of studies, mostly with adults. Meta-analyses indicate a small but significant inverse relationship between central nervous 5-HT availability and aggression, but genetically informed studies suggest two pathways: one to reactive aggression and the other to proactive aggression. Method: We conducted a systemic review on central nervous 5-HT function in children and adolescents, with attention to the function of aggression. Results: In total, 675 articles were screened for relevance, with 45 reviewed. These included blood assays (e.g. plasma, 5-HIAA; platelet 5-HTR 2A ), epigenetic studies, retrospective PET studies and 5-HT challenge paradigms (e.g. tryptophan depletion). Overall, findings were mixed, with support both for negative and for positive associations of central nervous 5-HT function with aggression in children and adolescents. Conclusion: We propose factors that may be blurring the picture, including problems in the conceptualization and measurement of aggression in young people, the lack of prospective designs and the bias towards clinical samples of boys. Research needs to account for variance in the both motivation for and implementation of aggression, and look to the behavioural economics literature to consider the roles of reward, vengeance and self-control more clearly.• Central nervous serotonin (5-HT) function plays a complex and nonlinear role in child and adolescent aggression, with evidence indicating a role for low-expression of 5-HT as well as a role for increased central nervous availability of 5-HT.• Low central nervous 5-HT function may play a role in impulsive implementation of aggression, and increased 5-HT availability may play a role in deliberate, planned implementation and/or in callousunemotional traits that enable aggression for some children and adolescents.

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Section: Literature Reviewmentioning

confidence: 99%

“…ADP combined with a 1.0 μg dose of 5‐HT resulted in amplification of the ATP response amongst the CD group, but not the HC group. Moss and Yao cautiously interpreted this as modest support for a problem in heightened regulation of platelet 5‐HT 2A receptors, possibly due to overall 5‐HT deficit.…”

Section: Literature Reviewmentioning

confidence: 99%