Platelet-Derived Growth Factor-A Overexpression Correlates with Atrial Fibrosis in the Patients with Atrial Fibrillation Secondary to Rheumatic Valvular Disease

Su, Mengxia; Zhao, Rui; Wang, Xu; Yang, Yue; Feng, Mang; Pan, Jianji

doi:10.4236/ijcm.2022.1311038

Cited by 1 publication

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“…Its peptide chain consists of 196 and 211 amino acid residues. It is highly expressed in the heart, skeletal muscle and pancreas [7] [8] [9] and passes through the specific receptor PDGFR-α on the plasma membrane. It binds and crosses the plasma membrane to transmit information to the cell interior, and generates response through a series of actions.…”

Section: Discussionmentioning

confidence: 99%

Expression of PDGFR-<i>α</i> in Patients with Valvular Atrial Fibrillation

Su¹,

Wang²,

Zhao³

et al. 2023

IJCM

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Objective: To investigate the expression of Platelet-derived growth factor receptor alpha (PDGFR-α) in patients who have valvular atrial fibrillation. Methods: In this research, eighty-four patients with rheumatic heart disease who were going to undertake cardiac surgery were included. The subjects were divided into two groups: the AF group and the sinus rhythm group, the quantities are 39 and 45 respectively. Before the surgery, baseline demographics, physical examination, routine laboratory testing, echocardiography, echocardiographic data and additional clinical data were available for all patients. The right atrial tissue of the subjects was separated during surgery, with an area of approximately 0.3 -0.5 mm 3 . Immunofluorescence staining was used to analyze the distribution of PDGFR-α of atrial tissue. mRNA of PDGFR-α in atrial tissue were determined by real-time quantitative PCR (Polymerase Chain Reaction); Western-Blot technique was used to measure the protein of PDGFR-α in atrial tissue. Results: There were no significant differences (P > 0.05) in sex ratio, age, blood pressure, blood biochemistry, and other aspects of medical history between the two groups. However, the right and left atrium diameters in the AF group were markedly larger than those in the SR group (P < 0.05). Moreover, the mRNA and protein of PDGFR-α from right atrial tissue were obviously higher in the AF group than that in the SR group (P < 0.05). Conclusion: The expression of PDGFR-α in the right atrial tissue of patients with atrial fibrillation was found to be significantly higher.

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Section: Discussionmentioning

confidence: 99%