Platelet-derived growth factor regulates the proliferation and differentiation of human melanocytes in a differentiation-stage-specific manner

Hirobe, Tomohisa; Shibata, Tatako; Fujiwara, Rumiko; Satô, Kiyoshi

doi:10.1016/j.jdermsci.2016.05.010

Cited by 12 publications

(4 citation statements)

References 44 publications

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“…Adipocytes are necessary and sufficient to activate HFSCs, and this is regulated by Platelet‐derived growth factor (PDGF). PDGF promotes the proliferation of human melanoblasts and differentiation of melanocytes, indicating that adipose‐secreted PDGF may also regulate McSCs activation and differentiation. Still, how this relatively small amount of McSCs maintain homeostasis and regenerate in the complex macroenvironment remains further exploration.…”

Section: Regulation Of Mcsc By Extra‐follicle Signalsmentioning

confidence: 99%

Regulation of melanocyte stem cells in the pigmentation of skin and its appendages: Biological patterning and therapeutic potentials

Qiu

Chuong

Lei

2019

Experimental Dermatology

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Skin evolves essential appendages and indispensable types of cells that synergistically insulate the body from environmental insults. Residing in the specific regions in the skin such as epidermis, dermis and hair follicle, melanocytes perform an array of vital functions including defending the ultraviolet radiation and diversifying animal appearance. As one of the adult stem cells, melanocyte stem cells in the hair follicle bulge niche can proliferate, differentiate and keep quiescence to control and coordinate tissue homeostasis, repair and regeneration. In synchrony with hair follicle stem cells, melanocyte stem cells in the hair follicles undergo cyclic activation, degeneration and resting phases, to pigment the hairs and to preserve the stem cells. Disorder of melanocytes results in severe skin problems such as canities, vitiligo and even melanoma. Here, we compare and summarize recent discoveries about melanocyte in the skin, particularly in the hair follicle. A better understanding of the physiological and pathological regulation of melanocyte and melanocyte stem cell behaviours will help to guide the clinical applications in regenerative medicine.

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Section: Regulation Of Mcsc By Extra‐follicle Signalsmentioning

confidence: 99%

Regulation of melanocyte stem cells in the pigmentation of skin and its appendages: Biological patterning and therapeutic potentials

Qiu

Chuong

Lei

2019

Experimental Dermatology

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“…RAS up-regulates JAK2 through prolactin. According to a few previous findings by us and others (13)(14)(15)(16), PDGF (platelet-derived growth factor) is the major melanogenic serum factor(s) essential for the α-MSH/IBMX-induced melanogenesis, because it activates its receptor (PDGFR) Tyr-kinase that in turn trans-activates EGFR (epidermal growth factor receptor=ErbB1) Tyr-kinase, leading to the activation of PAK1 through the oncogenic RAS-PI3 kinase-RAC/ CDC42 pathway (13). Thus, PDGF in serum alone can activates PAK1 and induce melanogenesis up to a half way.…”

Section: Discussionmentioning

confidence: 89%

The serum/PDGF-dependent "melanogenic" role of the minute level of the oncogenic kinase PAK1 in melanoma cells proven by the highly sensitive kinase assay

Nguyen

Tawata

et al. 2016

DD&T

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“…Similar changes in melanocyte morphology in a platelet lysate-enriched culture medium were observed [ 58 ]. These changes may be attributed to the high PDGF-BB contained in the platelets, as the PDGF-BB has been shown to stimulate melanogenesis, dendritogenesis, and the differentiation of human melanocytes [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

A Simple Drug Delivery System for Platelet-Derived Bioactive Molecules, to Improve Melanocyte Stimulation in Vitiligo Treatment

et al. 2020

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Vitiligo is the most common depigmentation disorder of the skin. Currently, its therapy focuses on the halting of the immune response and stimulation of the regenerative processes, leading to the restoration of normal melanocyte function. Platelet-rich plasma (PRP) represents a safe and cheap regenerative therapy option, as it delivers a wide spectrum of native growth factors, cytokines and other bioactive molecules. The aim of this study was to develop a simple delivery system to prolong the effects of the bioactive molecules released from platelets. The surface of electrospun and centrifugally spun poly-ε-caprolactone (PCL) fibrous scaffolds was functionalized with various concentrations of platelets; the influence of the morphology of the scaffolds and the concentration of the released platelet-derived bioactive molecules on melanocytes, was then assessed. An almost two-fold increase in the amount of the released bioactive molecules was detected on the centrifugally spun vs. electrospun scaffolds, and a sustained 14-day release of the bioactive molecules was demonstrated. A strong concentration-dependent response of melanocyte to the bioactive molecules was observed; higher concentrations of bioactive molecules resulted in improved metabolic activity and proliferation of melanocytes. This simple system improves melanocyte viability, offers on-site preparation and is suitable for prolonged topical PRP administration.

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Platelet-derived growth factor regulates the proliferation and differentiation of human melanocytes in a differentiation-stage-specific manner

Cited by 12 publications

References 44 publications

Regulation of melanocyte stem cells in the pigmentation of skin and its appendages: Biological patterning and therapeutic potentials

Regulation of melanocyte stem cells in the pigmentation of skin and its appendages: Biological patterning and therapeutic potentials

The serum/PDGF-dependent "melanogenic" role of the minute level of the oncogenic kinase PAK1 in melanoma cells proven by the highly sensitive kinase assay

A Simple Drug Delivery System for Platelet-Derived Bioactive Molecules, to Improve Melanocyte Stimulation in Vitiligo Treatment

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