Platelet disorders in the elderly

Terranova, Laura; Gerli, Giancarla; Cattaneo, Marco

doi:10.1017/cbo9780511545238.029

Cited by 3 publications

(3 citation statements)

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“…The incidence of thrombocytopenia among solid cancer patients is rather low i.e., ranging between 10%-25% among breast cancer, ovarian and germ cell cancer patients who were treated with intensive chemotherapy. However thrombocytopenia incidence is high among acute leukemia patients [56][57][58][59][60][61][62][63].…”

Section: Thrombocytopeniamentioning

confidence: 99%

Supportive and Palliative Care in Solid Cancer Patients

Hassan¹,

Yusoff²,

Othman³

2013

Cancer Treatment - Conventional and Innovative Approaches

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Section: Thrombocytopeniamentioning

confidence: 99%

Supportive and Palliative Care in Solid Cancer Patients

Hassan¹,

Yusoff²,

Othman³

2013

Cancer Treatment - Conventional and Innovative Approaches

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“…Thrombocytopenia is common in cancer patients; it usually results from the use of conventional chemotherapy and, at times, can be a doselimiting factor for chemotherapy administration. The incidence of thrombocytopenia among solid cancer patients is rather low, ranging between 10%-25% among breast cancer, ovarian cancer, and germ cell cancer patients who were treated with intensive chemotherapy, but it is high among acute leukemia patients [1][2][3][4][5][6][7][8][9][10]. Thrombocytopenia is a major detrimental side effect of chemotherapy as it can lead to hemorrhage in vital organs, particularly the brain, specifically in solid cancer patients who were treated with chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Association and Correlation of Different Chemotherapy Regimens and Doses with Incidence and Severity of Thrombocytopenia among Solid Cancer Patients

Yusoff

Wayyes

Hareeja

et al. 2021

Al-Rafidain J Med Sci

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Background: Thrombocytopenia is an abnormal decrease in platelet numbers and is a major detrimental side effect of chemotherapy or of cancer itself. Thrombocytopenia can lead to hemorrhage in vital organs, which is particularly a problematic specifically in solid cancer patients, and has a substantial negative effect on cancer patients’ quality of life (QOL). Thrombocytopenia ranges from mild bleeding from small blood vessels to severe bleeding from large blood vessels. Objectives: The present study aimed to describe the effect of chemotherapy regimens and doses on thrombocytopenia incidence and severity among solid cancer patients with thrombocytopenia. Materials and Methods: This retrospective observational study was conducted in Penang Hospital, a government hospital on Penang island, and included 341 cancer patients with thrombocytopenia who were admitted between 2003 and 2009. The main statistical tests used were the Chi-square test and logistic regression. The level of significance was set at P < 0.05. Results: Of the 341 patients included, 21 (6.2%) had thrombocytopenia before chemotherapy and the remaining 320 (93.8%) developed it after chemotherapy. The majority of patients had moderate thrombocytopenia (n=172; 53.8%), followed by mild (n=97; 30.3%), and severe thrombocytopenia (n=51; 15.9%). FEC, 5-FU+5-FU, Docetaxel and Cisplatin regimen had strong associations and correlation with thrombocytopenia incidence and severity, but the associations and correlations for thrombocytopenia severity were stronger than those for incidence. The dosage of 5-FU, cyclophosphamide, docetaxel and cisplatin plays a critical role in thrombocytopenia incidence and severity. Conclusion: Monitoring and determination of hemoglobin levels for cancer patients treated with FEC, 5-FU+5-FU, Docetaxel, and Cisplatin specifically with high doses must be emphasized and a focus of particular attention.

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“…About 10-25% of solid cancer patients (specifically: breast cancer, ovarian and germ cell) who were treated with intensive chemotherapy suffer from incidence of thrombocytopenia. Even though, incidence of thrombocytopenia among acute leukemia patients is higher than its incidence among other types of cancer [1][2][3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Role of Cancer and Chemotherapy in the Incidence of Thrombocytopenia

Hassan¹

2013

Pharm Anal Acta

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Platelet disorders in the elderly

Cited by 3 publications

References 0 publications

Supportive and Palliative Care in Solid Cancer Patients

Supportive and Palliative Care in Solid Cancer Patients

Association and Correlation of Different Chemotherapy Regimens and Doses with Incidence and Severity of Thrombocytopenia among Solid Cancer Patients

Role of Cancer and Chemotherapy in the Incidence of Thrombocytopenia

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