Platelet Function and Diabetes Mellitus

Microvascular Breast Reconstruction in the Diabetic Patient

“…These factors include an increase in platelet adhesion, 21 increased production of thromboxane, 22 reduced plasminogen activator production, 23 a decrease in endothelial prostacyclin, 24 and altered lipoprotein metabolism. 25 An increase in endothelial damage has been demonstrated in the diabetic animal model.…”

Aspirin for Primary Prevention of Cardiovascular Events in People With Diabetes

“…Although platelets from patients with diabetes have altered function, it is unclear what, if any, impact that finding has on the required dose of aspirin for cardioprotective outcomes in the diabetic patient (29). Many alternate pathways exist for platelet activation and aggregation (adenosine diphosphate, thrombin, epinephrine, von Willebrand factor) that are independent of thromboxane A2 and thus not sensitive to the effects of aspirin (30).…”

Dietary fiber and coronary heart disease

“…Death from atherosclerosis is two to three times higher in persons with diabetes 140 -141 than in nondiabetic persons. Many factors commonly present in individuals with diabetes may lead to increased CHD risk, including hypercholesterolemia, 142 hypertriglyceridemia, 108 changes in Critical Reviews In platelet function, 143 alterations in vascular wall morphology, 140 -144 and higher ambient insulin concentrations. 141 -145 Only a portion of increased cardiovascular risk shown in Table 5 98 can be explained by concomitant risk factors.…”