Platelet Functions Beyond Hemostasis

Platelet immunology from the inside out

“…There are many examples of how platelets can alter immunity in different disease settings, and the reader is referred to more comprehensive reviews on the subject [4][5][6][7][8]. We will only highlight a few examples here.…”

“…There have been numerous papers published on how platelets can affect the innate immune system, and for brevity, a few examples will be given. The readers are referred to the cited reviews for a more comprehensive discussion of this subject [4][5][6][7][8]. It is now well known that platelets can directly interact with neutrophils and cause them to, for example, secrete neutrophil extracellular traps (NETs) [27].…”

“…This is due the platelet's capability to express and secrete a multitude of immune molecules which are capable of regulating immune responses. An in-depth discussion of how platelets utilize these molecules to affect inflammatory and immune reactions has been previously comprehensively reviewed [4][5][6][7][8], and this paper will only briefly outline some of the major ways in which platelets can act as immune cells and regulate immunological functions.…”

Platelet to Lymphocyte Ratio, Platelet and Lymphocyte Counts in Assessing the Severity of Disease in Valvular Heart Diseases

“…Platelets play a role in transportation of leukocytes to the sites of inflammation and vascular injury and also in mobilizing anti-inflammatory, proinflammatory and angiogenic factors into peripheral circulation. 6 The resulting inflammatory conditions lead to increased proliferation in megakaryocytic series and relative thrombocytosis. Treatments are available to decrease inflammation and reduce the acceleration of degenerative valve stenosis.…”

Πλειοτροπικές Δράσεις Αγωνιστών Αιμοπεταλιακών Υποδοχέων

“…Η ρξφληα θιεγκνλή θαζνξίδεη ηελ εμέιημε ηεο αζεξσκαηηθήο πιάθαο, απφ ηα πξψηα ζηάδηα έσο ηε ξήμε θαη ηελ αζεξνζξφκβσζε. Τπάξρνπλ νινέλα θαη πεξηζζφηεξεο ελδείμεηο φηη ηα αηκνπεηάιηα δηαδξακαηίδνπλ ζεκαληηθφ ξφιν ζηελ έλαξμε θαη ηε δηαηήξεζε ηεο ζπγθξηκέλεο δηαδηθαζίαο, κέζσ ζχλζεησλ αιιειεπηδξάζεσλ κε ηα ECs θαη θιεγκνλψδε θχηηαξα[235][236][237]. Η έλαξμε ηεο αζεξνζθιήξσζεο απαηηεί ηελ παξνπζία είηε ελεξγνπνηεκέλσλ αηκνπεηαιίσλ είηε ελεξγνπνηεκέλσλ ECs ή θαη ησλ δχν[238].…”