Platelet glycoprotein IIb polymorphism, traditional risk factors and non‐fatal myocardial infarction in young women

Abstract

Summary. Several platelet glycoprotein polymorphisms have been associated with an increased risk of myocardial infarction (MI) in studies that included predominantly men. In a population-based sample of 68 Caucasian women , 45 years old with non-fatal MI and 346 demographically similar control subjects, we found an increased risk of MI among women who possessed at least one copy of the glycoprotein IIb Ser 843 allele compared with those lacking the Ser 843 allele (odds ratio 1´85; 95% confidence interval 1´03±3´33). The increased risk was present only in subgroups of women who smoked cigarettes, had hypercholesterolaemia or who had a family history of early onset MI. The Ser 843 variant of glycoprotein IIb may be associated with an increased risk of MI in young women with other cardiovascular risk factors. Additional studies involving larger numbers of subjects are needed to confirm this preliminary finding.

Platelet glycoprotein IIb HPA-3 polymorphism and acute coronary syndromes

“…Moreover, in another study no significant relation was found between the HPA-3 genotypes and the risk for thrombosis and restenosis after stent placement [8]. On the contrary, a small study on young women from the US found an association between HPA-3b and myocardial infarction in the presence of other risk factors [9]; women having the HPA-3b allele and being current smokers had a 10-fold increased risk for myocardial infarction. Finally, Reiner et al [18] observed an association between HPA-3b homozygosity and ischemic stroke in young women with risk factors for atherosclerosis.…”

“…The HPA3a and 3b alleles encode for subunits that only differ at position 843 where Ile substitutes Ser. Most, but not all, of the studies agree that the HPA-1b allele represents an inherited risk predisposing to acute coronary syndromes [4][5][6], while the reports on the significance of the polymorphisms of the a subunit are rare [6][7][8][9]. Moreover there are no data on the significance of HPA-3 alleles in the genesis of ST segment elevation myocardial infarction (STEMI) or unstable angina/ non-ST segment elevation infarction (NSTEMI-UA).…”

Association of Platelet Membrane Glycoprotein HPA-2a/b, GP VI T13254C, and GP IbαVNTR Polymorphisms with Risk of Coronary Artery Disease: A Meta-Analysis

“…Among these, one study contained two independent researches [13], and three studies explored HPA-2a/b and GP Ib α VNTR, simultaneously [5, 11, 16]. In addition, six studies enrolled community-based populations [8, 9, 12, 14, 21, 22], and the rest were controlled through hospital populations. Only two articles mentioned gene sequencing using a blind method [16, 20] (Table 1).…”

The Genetics of Thrombosis

“…Hence, it appears that the Pro33 polymorphism of glycoprotein IIIa alters human platelet aggregation, adhesion, and secretion, perhaps through the mechanism of increased signaling and cytoskeletal changes, leading to stabilization of platelet-platelet and/or platelet-extracellular matrix interactions (236). Another variant that has been studied in the GPIIb-IIIa gene is the Ile843Ser polymorphism that has been shown to be associated with increased risk of MI in young women in the presence of other risk factors (247), but other studies have shown negative results (248,249).…”