Platelet indices are novel predictors of hospital mortality in intensive care unit patients

Zhang, Zhongheng; Xu, Xiao; Ni, Hongying; Deng, Hongsheng

doi:10.1016/j.jcrc.2014.04.020

Cited by 62 publications

(71 citation statements)

References 39 publications

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“…In adults, some studies showed that the initial MPV, as a predictor of mortality in critically ill patients, was not significantly associated with in-hospital mortality (19), although other studies showed that elevated MPV during hospitalization was a predictor of mortality in critically ill adults (9,20). High MPV was suggested to be associated with overall survival in various diseases such as cancer, cardiac disease, septic shock, kidney injury, and patients hospitalized in a respiratory intensive care unit (21)(22)(23)(24)(25). On the other hand, subsequent MPV and PDW are suggested to be associated with mortality in critically ill children receiving mechanical ventilation, however initial admission MPV was not associated with mortality in those children (17).…”

Section: Discussionmentioning

confidence: 99%

Using Platelet Parameters to Anticipate Morbidity and Mortality Among Preterm Neonates: A Retrospective Study

Ohto

Nollet

et al. 2020

Front. Pediatr.

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Background: Platelets participate in many physiological and pathological functions and some platelet parameters predict adult diseases. However, few studies report whether platelet parameters may reflect neonatal disease and mortality in a large cohort.Objective: We aimed to investigate whether platelet parameters could predict bronchopulmonary dysplasia (BPD), necrotizing enterocolitis (NEC), intraventricular hemorrhage (IVH), and NICU mortality. Study Design and Methods:This retrospective cohort study examined records from 2006 to 2017 at the neonatal intensive care unit (NICU) of Fukushima Medical University Hospital. We retrospectively investigated platelet count, plateletcrit (PCT), mean platelet volume (MPV), and platelet distribution width (PDW) on the first day of life in preterm newborns born <32 weeks' gestation admitted to our NICU from 2006 to 2017. Receiver operating characteristic (ROC) and multiple regression analyses, along with Cox proportional hazard modeling, identified independent predictors of morbidities and mortality in preterm newborns.Results: Of 1,501 neonates admitted to our NICU, a total of 305 preterm newborns were included in this study. Gestational age, birth weight, and Apgar score were significantly lower in non-survivors than in survivors. Platelet count, PCT, PDW and PMI did not differ significantly between the two groups, whereas mean MPV in non-survivors was significantly higher than in survivors (10.5 fl vs. 10.0 fl, p = 0.001). Multivariate Cox hazard modeling showed that shorter GA [HR: 0.628, 95% CI: 0.464-0.840, p = 0.003], male sex [HR: 0.269, 95% CI: 0.113-0.640, p = 0.001], and MPV [HR: 1.469, 95% CI: 1.046-2.063, p = 0.026] independently predicted overall survival. Per receiver operating curve, an MPV threshold of 10.2 fl. MPV predicts prognosis in neonates with a sensitivity of 72.4% and a specificity of 58.6% (AUC = 0.685, 95% CI: 0.600-0.789, p = 0.001). Furthermore, multivariate analysis revealed that platelet parameters were not associated Go et al. Platelet Parameters in Neonateswith BPD and NEC, whereas small for gestational age (SGA), Apgar score at 5 min, and low PCT were associated with intraventricular hemorrhage (IVH).Conclusion: This study demonstrates that low PCT predicts IVH, and MPV ≥ 10.2 fL correlates with mortality among infants born after <32 weeks' gestation.

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Section: Discussionmentioning

confidence: 99%

Using Platelet Parameters to Anticipate Morbidity and Mortality Among Preterm Neonates: A Retrospective Study

Ohto

Nollet

et al. 2020

Front. Pediatr.

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“…Platelet (PLT) indices are a group of parameters that are used to measure the total amount of PLTs, PLTs morphology and proliferation kinetics (Zhang et al, 2014). Most important parameters among them are plateletcrit (PCT), mean platelet volume (MPV) and platelet distribution width (PDW) (Wiwanitkit, 2004).…”

Section: Article Infomentioning

confidence: 99%

Systemic Inflammatory Response Syndrome Associated Alterations in Platelet Indices in Dogs

Jasmin¹,

Balagangatharathilagar²,

Vairamuthu³

et al. 2018

Int.J.Curr.Microbiol.App.Sci

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“…A part of PLT indices that include also the PLT count, plateletcrit (PCT), platelet distribution width (PDW) and mean platelet volume (MPV) are widely used in medical field (3). It has been recently revealed that these indices are associated with various diseases and the prognosis of various diseases as well as hematological system disorders (4,5).…”

Section: Introductionmentioning

confidence: 99%

Correlation Between Vitamin D Level and Platelet Indices in Children Aged 0-18 Years

Coşkun¹,

Şahin²

2018

Haseki

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Aim:In this study, we aim to investigate whether any the correlation exists between 25-hidroxy vitamin D (vitamin D) and platelet indices in childhood. Methods:We planned a retrospective study. Firstly, we scanned vitamin D and hemogram tests of children, who consulted to pediatric clinic with any simple complaint from January 2014 to December 2016. We finally included 346 children (168 female and 178 male) aged 0-18 years in order to evaluate the correlation between vitamin D, and platelet indices.Results: Significant differences were not observed between the average ages of the study groups (p=0.856) as well as sex (p=0.907). We did not determine any significant difference among seasons in terms of vitamin D level (p=0.512). Finally, we did not also found any correlation between vitamin D level and platelet indices in all groups (p>0.05). Conclusion:Vitamin D level was not related to platelet indices in healthy children. On the other hand, we consider that there is a need further studies to validate our findings. Sonuç: Sağlıklı çocuklarda vitamin D düzeyi trombosit indeksleri ile ilişkili değildi. Bununla birlikte, bulgularımızı doğrulayacak daha ileri çalışmalara ihtiyaç olduğu düşüncesindeyiz.

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Platelet indices are novel predictors of hospital mortality in intensive care unit patients

Cited by 62 publications

References 39 publications

Using Platelet Parameters to Anticipate Morbidity and Mortality Among Preterm Neonates: A Retrospective Study

Using Platelet Parameters to Anticipate Morbidity and Mortality Among Preterm Neonates: A Retrospective Study

Systemic Inflammatory Response Syndrome Associated Alterations in Platelet Indices in Dogs

Correlation Between Vitamin D Level and Platelet Indices in Children Aged 0-18 Years

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