2016
DOI: 10.1172/jci.insight.88245
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Platelet integrin α6β1 controls lung metastasis through direct binding to cancer cell–derived ADAM9

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Cited by 97 publications
(55 citation statements)
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“…Lin et al also found that the in vivo inhibition of ADAM9 protein expression on lung cancer cells decreased brain metastasis by enhancing the tissue plasminogen activator. 26 Mammadova-Bach et al 32 showed that the interplay between platelet α6β1 and tumour cell-expressed ADAM9 promotes efficient lung metastasis. ADAM9 overexpression portends a poor prognosis for patients with non-small cell lung cancer.…”
Section: Discussionmentioning
confidence: 99%
“…Lin et al also found that the in vivo inhibition of ADAM9 protein expression on lung cancer cells decreased brain metastasis by enhancing the tissue plasminogen activator. 26 Mammadova-Bach et al 32 showed that the interplay between platelet α6β1 and tumour cell-expressed ADAM9 promotes efficient lung metastasis. ADAM9 overexpression portends a poor prognosis for patients with non-small cell lung cancer.…”
Section: Discussionmentioning
confidence: 99%
“…On the other hand, the low expression of ADAM9 on tumor cells also impedes the interaction between platelets and tumor cells in breast cancer and melanoma. The interaction between ADAM9 and integrin β1 has been proven in several studies, which suggests that ADAM9 may have a role in platelet-mediated metastasis [ 119 ] ( Figure 2 ).…”
Section: Adam9 In the Tumor Microenvironmentmentioning
confidence: 99%
“…This shielding activity also promotes transendothelial extravasation of tumor cells at secondary sites . Defective platelet function or reducing platelet counts was able to strongly inhibit tumor metastasis in various transgenic mouse models . Nevertheless, the severe bleeding complication has limited the clinical utility of antiplatelet strategies .…”
Section: Nanoparticle‐mediated Tumor Vessel Targetingmentioning
confidence: 99%