Platelet Lipid Composition in Human Migraine

Bottomley, J; Hanington, Edda; Jones, Rosanne; Chapman, Don M.

doi:10.1111/j.1526-4610.1982.hed2206256.x

Cited by 9 publications

(4 citation statements)

References 11 publications

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“…Our in vitro finding nevertheless does not rule out a tendency to hyperaggregant platelet hyperactivity in vivo [17]. The fluidity of the membrane thus appears m be stable, as others [1] have found. Some workers [23] think that high intracellular concentrations of Ca + + in attack-free intervals should be attributed to peculiar conditions intrinsic to the platelet or alternatively to extrinsic plasma factors.…”

Section: Discussioncontrasting

confidence: 68%

“…In particolare sono stati studiati la produzione di malondialdeide (MDA), la concentrazione del Ca + + intracellulare e la struttura fosfolipidica di membrana con probe fluorescente DPH (1,3,5 hexatriene). In particolare sono stati studiati la produzione di malondialdeide (MDA), la concentrazione del Ca + + intracellulare e la struttura fosfolipidica di membrana con probe fluorescente DPH (1,3,5 hexatriene).…”

Section: Sommariounclassified

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Platelet changes in classic migraine

et al. 1993

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We investigated some ultrastructural aspects of platelet activity in patients with classic migraine during an attack-free period. We focused on the production of malondialdehyde (MDA), the intracellular concentration of Ca++ and the membrane phospholipid structure using a DPH (1,6 diphenyl-1,3,5 hexatriene) fluorescent probe. Our study comprised 20 patients with classic migraine and 5 healthy controls, from whom 10 cc samples of blood were collected in test tubes containing sodium citrate (1/9 cc). We found no significant differences in MDA production between migraineurs and controls either before or after stimulation with thrombin. The same applies to the concentration of intracellular Ca++ (Ca++i). The membrane lipid composition assessed by DPH fluorescent probe was normal both in migraineurs and in controls. Our findings suggest no intrinsic activation of platelet aggregation.

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Section: Discussioncontrasting

confidence: 68%

Section: Sommariounclassified

Platelet changes in classic migraine

et al. 1993

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“…Following this, studies were carried out in the 1970’s-1980’s comparing platelet lipid composition in a diverse and somewhat unusual array of population groups and species 5-15 . Also, with interest in the role of lipids causing vascular disease increasing around that time, the effects of dietary supplementation with lipids on platelet lipid fatty acid composition (omega-3, fish oil, corn oil, or varying dietary fat) was characterized 16-18 .…”

Section: Introductionmentioning

confidence: 99%

Platelet Lipidomics

O'Donnell

Murphy

Watson³

2014

Circulation Research

135

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Lipids are diverse families of biomolecules that perform essential structural and signaling roles in platelets. Their formation and metabolism is tightly controlled by enzymes and signal transduction pathways, and their dysregulation leads to significant defects in platelet function and disease. Platelet activation is associated with significant changes to membrane lipids, and formation of diverse bioactive lipids that play essential roles in hemostasis. In recent years, new generation mass spectrometry analysis of lipids (termed “lipidomics”) has begun to alter our understanding of how these molecules participate in key cellular processes. While, the application of lipidomics to platelet biology is still in its infancy, seminal earlier studies have shaped our knowledge of how lipids regulate key aspects of platelet biology, including aggregation, shape change, coagulation and degranulation, as well as how lipids generated by platelets influence other cells, such as leukocytes and the vascular wall, and thus how they regulate hemostasis, vascular integrity and inflammation, as well as contribute to pathologies including arterial/deep vein thrombosis and atherosclerosis. This review will provide a brief historical perspective on the characterization of lipids in platelets, then an overview of the new generation lipidomic approaches, their recent application to platelet biology, and future perspectives for research in this area. The major platelet-regulatory lipid families, their formation, metabolism, and their role in health and disease, will be summarized.

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“…Fatty acid profiles, cholesterol content and the cholesterol/phospholipid ratio of platelets in migraineurs and controls are similar. 97 However, some authors have noticed a difference in some aspects of phosphocholines within subgroups of migraineurs. 98 Concluding comments.…”

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confidence: 99%