Platelet-Membrane-Camouflaged Black Phosphorus Quantum Dots Enhance Anticancer Effect Mediated by Apoptosis and Autophagy

Shang, Yilun; Wang, Qinghai; Wu, Bin; Zhao, Qiangqiang; Li, Jian; Huang, Xueyuan; Chen, Wansong; Gui, Rong

doi:10.1021/acsami.9b04735

Cited by 71 publications

(78 citation statements)

References 51 publications

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“…Due to such targeting effect, PM/PLGA/DTX showed higher inhibition of tumor growth in vivo. Moreover, PNPs have been made with different cores to deliver various anticancer compounds for the treatment of cancers in mouse xenograft models of colorectal cancer (HT29 cells), [63] liver cancer (H22 cells), [64] breast cancer (MCF-7 cells), [65] and ovarian cancer (SK-OV-3 cells). [66] In addition to small-molecule anticancer compounds, PNPs were also used to target small interfering RNA (siRNA) in vivo to silence tumor-relevant genes (Figure 4).…”

Section: Targeting Cancer Cells For Cancer Treatment and Detectionmentioning

confidence: 99%

Drug Targeting via Platelet Membrane–Coated Nanoparticles

et al. 2020

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Platelets exhibit distinct surface moieties responsible for modulating their adhesion to various disease‐relevant substrates involving vascular damage, immune evasion, and pathogen interactions. Such broad biointerfacing capabilities of platelets have inspired the development of platelet‐mimicking drug carriers that preferentially target drug payloads to disease sites for enhanced therapeutic efficacy. Among these carriers, platelet membrane–coated nanoparticles (denoted “PNPs”) made by cloaking synthetic substrates with the plasma membrane of platelets have emerged recently. Their “top‐down” design combines the functionalities of natural platelet membrane and the engineering flexibility of synthetic nanomaterials, which together create synergy for effective drug delivery and novel therapeutics. Herein, the recent progress of engineering PNPs with different structures for targeted drug delivery is reviewed, focusing on three areas, including targeting injured blood vessels to treat vascular diseases, targeting cancer cells for cancer treatment and detection, and targeting drug‐resistant bacteria to treat infectious diseases. Overall, current studies establish PNPs as versatile nanotherapeutics for drug targeting with strong potentials to improve the treatment of various diseases.

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Section: Targeting Cancer Cells For Cancer Treatment and Detectionmentioning

confidence: 99%

Drug Targeting via Platelet Membrane–Coated Nanoparticles

et al. 2020

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“…Platelets have pathophysiological affnity with tumors [20]. The interaction between P-selectin and CD44 partially contributes to the binding of PM-camouflaged nanomaterials to the surface of breast cancer cells [4,21].…”

Section: Effect Of Irradiation On the Endocytosis Of Pinps@pm By Cancmentioning

confidence: 99%

Irradiation pretreatment enhances the therapeutic efficacy of platelet-membrane-camouflaged antitumor nanoparticles

et al. 2020

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Background: Cell membrane-based nanocarriers are promising candidates for delivering antitumor agents. The employment of a simple and feasible method to improve the tumor-targeting abilities of these systems is appealing for further application. Herein, we prepared a platelet membrane (PM)-camouflaged antitumor nanoparticle. The effects of irradiation pretreatment on tumor targeting of the nanomaterial and on its antitumor action were evaluated. Results: The biomimetic nanomaterial constructed by indocyanine green, poly(d,l-lactide-co-glycolide), and PM is termed PINPs@PM. A 4-Gy X-ray irradiation increased the proportions of G2/M phase and Caveolin-1 content in 4T1 breast cancer cells, contributing to an endocytic enhancement of PINPs@PM. PINPs@PM produced hyperthermia and reactive oxygen species upon excitation by near-infrared irradiation, which were detrimental to the cytoplasmic lysosome and resulted in cell death. Irradiation pretreatment thus strengthened the antitumor activity of PINPs@PM in vitro. Mice experiments revealed that irradiation enhanced the tumor targeting capability of PINPs@PM in vivo. When the same dose of PINPs@PM was intravenously administered, irradiated mice had a better outcome than did mice without X-ray pretreatment. Conclusion: The study demonstrates an effective strategy combining irradiation pretreatment and PM camouflage to deliver antitumor nanoparticles, which may be instrumental for targeted tumor therapy.

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“…Platelets have pathophysiological affnity with tumors [20]. The interaction between P-selectin and CD44 partially contributes to the binding of PM-camou aged nanomaterials to the surface of breast cancer cells [4,21]. After aggregation on the cell membrane, our data showed that PINPs@PM was endocytosed by 4T1 cells in a time-dependent manner.…”

Section: Effect Of Irradiation On the Endocytosis Of Pinps@pm By Cancmentioning

confidence: 76%

Irradiation pretreatment enhances the therapeutic efficacy of platelet-membrane-camouflaged antitumor nanoparticles

Chen

Shen

Han

et al. 2020

Preprint

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Backgroud: Cell membrane-based nanocarriers are promising candidates for delivering antitumor agents. The employment of a simple and feasible method to improve the tumor-targeting abilities of these systems is appealing for further application. Herein, we prepared a platelet membrane (PM)-camouflaged antitumor nanoparticle. The effects of irradiation pretreatment on tumor targeting of the nanomaterial and on its antitumor action were evaluated. Results: The biomimetic nanomaterial constructed by indocyanine green, poly(d,l-lactide-co-glycolide), and PM is termed PINPs@PM. A 4-Gy X-ray irradiation increased the proportions of G2/M phase and Caveolin-1 content in 4T1 breast cancer cells, contributing to an endocytic enhancement of PINPs@PM. PINPs@PM produced hyperthermia and reactive oxygen species upon excitation by near-infrared irradiation, which were detrimental to the cytoplasmic lysosome and resulted in cell death. Irradiation pretreatment thus strengthened the antitumor activity of PINPs@PM in vitro. Mice experiments revealed that irradiation enhanced the tumor targeting capability of PINPs@PM in vivo. When the same dose of PINPs@PM was intravenously administered, irradiated mice had a better outcome than did mice without X-ray pretreatment. Conclusion: The study demonstrates an effective strategy combining irradiation pretreatment and PM camouflage to deliver antitumor nanoparticles, which may be instrumental for targeted tumor therapy.

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Platelet-Membrane-Camouflaged Black Phosphorus Quantum Dots Enhance Anticancer Effect Mediated by Apoptosis and Autophagy

Cited by 71 publications

References 51 publications

Drug Targeting via Platelet Membrane–Coated Nanoparticles

Drug Targeting via Platelet Membrane–Coated Nanoparticles

Irradiation pretreatment enhances the therapeutic efficacy of platelet-membrane-camouflaged antitumor nanoparticles

Irradiation pretreatment enhances the therapeutic efficacy of platelet-membrane-camouflaged antitumor nanoparticles

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