Platelet membrane-coated nanoparticles for targeted drug delivery and local chemo-photothermal therapy of orthotopic hepatocellular carcinoma

Abstract

Specific targeted drug delivery and controllable release of drugs at tumor regions are two of the main challenges for hepatocellular carcinoma (HCC) therapy, particularly post metastasis.

Biomacromolecule-based photo-thermal agents for tumor treatment

“…65 Inspired by this, Wu et al developed a biomimetic antitumor platform with PLT membranes, NIR laser responsive polypyrrole (PPy) NPs, and DOX. 50 Pure PLT membranes were developed by a repeated freeze-thaw process. Due to the immune evasion ability of the PLT membrane, the hybrid PTAs had a higher accumulation in a Huh7 orthotopic tumor, resulting in an obvious temperature increase (the maximum temperature in a PLT-PPy + laser mouse and a PLT-PPy-DOX + laser mouse was 50.3 1C and 51.2 1C, respectively) (Fig.…”

Cell membrane-derived vesicles for delivery of therapeutic agents

“…A platelet membrane coating was recently reported for tumor-targeted delivery of photoresponsive nanoparticles encapsulating anticancer drugs 81 . In this application, polypyrrole nanoparticles were mixed with doxorubicin and platelet membranes and subsequently co-extruded.…”

“… Core particle Purpose Disease Ref. PLGA Immune evasion Tumor-targeting Mouse liver cancer (H22) 23 Immune evasion Subendothelium binding Pathogen adhesion Coronary restenosis Systemic bacterial infection 59 Magnetic nanoparticles Homing to atherosclerotic sites Atherosclerosis 44 , 84 Specific clearance of anti-platelet antibodies Immune thrombocytopenia purpura 85 Immune evasion Tumor-targeting Mouse breast cancer (4T1) 82 Polypyrrole Immune evasion Tumor-targeting Human liver cancer (Huh 7) 81 Mesoporous silica Enhance blood retention Improving target accumulation Carotid thrombosis 59 …”

“…Because the bioactivity of cell membrane-derived vesicles relies on multi-component membrane materials, effective quality control will require complete profiles of the major cell membrane components (total proteins, lipids and carbohydrates). The development of mass spectroscopy and advanced analysis techniques may allow high-throughput screening of cell membrane components based on proteomic, lipidomic or glycomic analyses 81 , 125 , 126 . In the case of cancer cell membrane-derived vesicles, the cell source is more homogeneous and easier to scale up.…”

Cancer Cell Membrane Technology for Cancer Therapy

“…[22] Further, repeated injections of PEGylated systems promote splenic synthesis, leading to an accelerated blood clearance. [23] To overcome the above limitations, the recent trend in cancer therapy is the surface mimicking of the nanocarriers by coating them with ghost cell membrane, [24] such as red blood cells (RBCs), [25] Leukocytes, [26] platelets, [27] neutrophils, [28] macrophages, [29] dendritic cells, [30] cancer cells, [31] stem cells, [32] exosomes [33] etc. Each of them provides a fascinating set of advantages.…”