Platelet-Membrane Fatty Acids, Platelet Aggregation, and Thromboxane Formation During a Mackerel Diet

Polyunsaturated fatty acids, hyperlipidemia, and thrombosis.

“…136 ' 140 In a rat study, no appreciable production of thromboxane A 3 from platelets was observed after feeding cod liver oil. 138 Thus, it seems more likely that the reduced platelet reactivity found with fish oil feeding is a result of reduced thromboxane A 2 levels rather than an increased production of the inactive thromboxane A 3 .…”

Eighth Gaddum Memorial Lecture University of London Institute of Education December 1980: Biological Importance of Prostacyclin

“…Studying seven Caucasians who had been on a mackerel diet for 1 week, Seiss and colleagues (1980) showed a reduced sensitivity of platelets to collagen, associated with a reduced ability to produce thromboxane B2, which was dependent on the ratio of C20:5/C20:4 in platelet phospholipids (Seiss, Roth, Scherer, Kurzmann, Bohlig & Weber, 1980). ADP-induced aggregation was significantly reduced in some subjects and platelet aggregation to exogenously added arachidonic acid was unchanged, indicating normal cyclo-oxygenase activity.…”

Effects of dietary α-linolenic acid deficiency during pregnancy and lactation on lipid fatty acid composition of liver and serum in the rat

“…As a precursor of prostanoids of the n-3 series, 20 : 5 n-3 plays an important role in the regulation of platelet aggregation and prevents the formation of thrombi (Dyerberg et al, 1978 ;Siess et al, 1980 ;Needleman ei al., 1979 ;Budowski et a/., 1980 ;Sinclair, 1981). Moreover, n-3 PUFA are powerful hypocholesterolemic and hypotriglyceridemic agents (Nordoy, 1965 ;Peifer, 1966 ;Dyerberg et al, 1975 ;Harris et al, 1983 ;Fehily et al, 1983 ;Durand et al, 1985).…”