Platelet parameters: Can they serve as biomarkers of glycemic control or development of complications in evaluation of type 2 diabetes mellitus?

Pujani, Mukta; Gahlawat, Himani; Agarwal, Charu; Chauhan, Varsha; Singh, Kanika; Lukhmana, Shveta

doi:10.4103/ijh.ijh_8_18

Cited by 14 publications

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“…The possible reason for this might be due to the presence of different factors associated with hyperglycemia, IR, dyslipidemia, low-grade inflammation, and oxidative stress possibly the common contributors for endothelial dysfunction, platelet hyperactivation, and increased activation of prothrombotic coagulation factors. 15,18 On contrary, a study conducted in Egypt 10 and Sudan 32 showed that PT between T2DM and controls had no significant difference. The reason for this…”

Section: Discussionmentioning

confidence: 93%

“…This finding was in agreement with the studies done in India and Ethiopia which reported an increased in PDW and MPV in T2DM than controls, respectively. 32,33 Similarly, other studies conducted in Turkey and Nigeria reported that MPV was significantly increased in T2DM as compared to controls. [34][35][36] Moreover, this study was in concurrent finding in Poland reported that increased MPV and PDW in T1DM as compared to controls, 37 and a similar finding was reported in Nigeria where high MPV in T1DM as compared to controls.…”

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confidence: 77%

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Basic Coagulation Profiles and Platelet Parameters Among Adult Type 1 and Type 2 Diabetes Patients at Dessie Referral Hospital, Northeast Ethiopia: Comparative Cross-Sectional Study

Ebrahim

Asrie

Getaneh

2021

JBM

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Background Diabetes is a heterogeneous group of metabolic disorders characterized by hyperglycemia. The disease is highly associated with micro-vascular and macro-vascular complications. Thus, the main aim of this study was to compare basic coagulation profiles and platelet parameters among type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), and healthy controls. Methods A comparative cross-sectional study was conducted at Dessie Referral Hospital from February to April 2019. A total of 180 study participants consisting of (60 T1DM, 60 T2DM, and 60 healthy controls) were enrolled using a systematic random sampling technique. Basic coagulation profiles and platelet parameters were determined using the HUMACLOT JUNIOR coagulometer and DIRUI BF 6500 automated hematology analyzer respectively. Non-parametric Kruskal–Wallis test supplemented with Dunn-Bonferroni correction and Spearman rank-order correlation test were used to compare basic coagulation profiles and platelet parameters among the groups. The test result was expressed in median and interquartile range and presented in texts and tables. P-value < 0.05 was considered to be statistically significant. Results Prothrombin time (PT) and international normalization ratio (INR) were significantly reduced in T2DM as compared to T1DM and healthy controls (p <0.05). Platelet distribution width (PDW) and mean platelet volume (MPV) were significantly increased in both T1DM and T2DM as compared to healthy controls (p <0.05). Moreover, PT and INR were negatively correlated with fasting blood glucose (FBG) among T1DM and PT, INR and activated partial thromboplastin time (APTT) were negatively correlated with FBG among T2DM. Conclusion Basic coagulation profiles and platelet parameters were significantly different between diabetes and controls where PT and INR in T2DM were significantly reduced as compared to T1DM and controls. However, PDW and MPV were significantly elevated in both T1DM and T2DM as compared to controls. Moreover, FBG was significantly negatively correlated with PT and INR among T1DM and FBG was significantly negatively correlated with PT, INR, and APTT among T2DM. Therefore, T2DM may be related to increased risk of thrombosis indicated by reduced PT and INR and high PDW and MPV than T1DM and controls. Basic coagulation profiles and platelet parameters should be regularly tested for early diagnosis and proper management of diabetes-related thrombosis.

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Section: Discussionmentioning

confidence: 93%

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confidence: 77%

Basic Coagulation Profiles and Platelet Parameters Among Adult Type 1 and Type 2 Diabetes Patients at Dessie Referral Hospital, Northeast Ethiopia: Comparative Cross-Sectional Study

Ebrahim

Asrie

Getaneh

2021

JBM

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“…A prolonged aPTT and PT is a clinical indicator of fibrinolytic tendency, while a shortened aPTT and PT reflects hypercoagulation conditions [8]. Shortened aPTT and PT have been widely reported among T2DM patients [3,9], along with increases in platelet activities [10]. These indicators, thus, are used for assessing and monitoring hypercoagulation among T2DM patients.…”

Section: Introductionmentioning

confidence: 99%

The acute effect of a moderate intensity ergocycle exercise on the coagulation parameters in type 2 diabetes mellitus patients: a feasibility study

Arovah

Kushartanti

2020

Clinical Diabetology

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Background. Type 2 diabetes mellitus (T2DM) patients experience higher atherothrombotic risks that could lead to cardiovascular diseases, due to increases in coagulation activities. The role of exercise in altering coagulation activities among T2DM patients is still inconclusive. This feasibility study aimed to evaluate the immediate effect of a moderate intensity ergocycle exercise, primary on the coagulation parameters and secondary on the systemic inflammation and blood glucose, in otherwise healthy T2DM patients. Methods. Ten T2DM patients (64 ± 7 year, 40% female) performed a 30-minute moderate-intensity ergocycle exercise at 50-60% of heart rate reserved. Coagulation parameters (activated partial thromboplastin time [aPTT], prothrombin time [PT] and platelet count), erythrocyte sedimentation rate, and blood glucose were assessed before the exercise (T0), immediately after the exercise (T1), and 30 minutes post exercise (T2). One-way repeated measured ANOVA was used to assess the outcomes over time. Results. All participants completed and adhered to the exercise protocol. There were increases in aPTT and PT but decreases in platelet count at T1 and T2 compared to at T0 (P < 0.05), indicating reduction in the coagula-tion activities. Those values, however, were still within normal ranges. The erythrocyte sedimentation rates were unaffected, while blood glucose decreased from 202 ± 35 mg/dL at T0 to 173 ± 33 mg/dL and 158 ± 30 mg/dL at T1 and T2 (P < 0.01). Conclusion. The 30-minute moderate-intensity ergocycle decreases coagulation activities and blood glucose but does not affect erythrocyte sedimentation rates in T2DM patients. Future studies should focus on the chronic adaptation of the coagulation parameters after ergocycle training among a T2DM patients with coagulation impairments.

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“…Studies were conducted to assess the hematological profile in diabetic and non-diabetic patients to evaluate the changes in blood cell parameters. The majority of the studies were conducted in patients with T2DM ( 14 , 18–21 , 28–33 , 40–43 ) and a few with T1DM ( 22 , 24–28 , 44 , 45 ). Moreover, 19 studies were observational ( 14 , 18–22 , 25–33 , 40–43 , 45 ) and 2 were experimental studies ( 24 , 44 ).…”

Section: Resultsmentioning

confidence: 99%

“…The majority of the studies were conducted in patients with T2DM ( 14 , 18–21 , 28–33 , 40–43 ) and a few with T1DM ( 22 , 24–28 , 44 , 45 ). Moreover, 19 studies were observational ( 14 , 18–22 , 25–33 , 40–43 , 45 ) and 2 were experimental studies ( 24 , 44 ). One study was conducted before 2010 ( 24 ), and 21 were conducted after 2010 ( 14 , 18–22 , 25–33 , 40–45 ) ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

Changes in selected hematological parameters in patients with type 1 and type 2 diabetes: a systematic review and meta-analysis

Bambo,

Asmelash,

Alemayehu

et al. 2024

Front. Med.

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BackgroundDiabetes mellitus is a chronic metabolic disorder that causes hyperglycemia and various life-threatening health problems. Although hematological parameters play a significant role in the progression and pathogenesis of diabetes, many studies have explored contradictory findings. Therefore, this evidence-based study aimed to determine the pooled mean difference of white blood cell and red blood cell parameters in diabetic patients in order to investigate hematological dysfunctions in type 1 and type 2 diabetes mellitus.MethodsArticles were extensively searched in bibliographic databases (PubMed, Cochrane library, Scopus, Web of Science, PsycINFO, Embase, online archives and university repositories) using appropriate entry terms. For studies meeting the eligibility criteria, the first author’s name, year of publication, study design and area, type of diabetes mellitus, sample size, and mean and standard deviation of hematological parameters were extracted using Microsoft Excel and exported to Stata 11 for meta-analysis. The pooled standardized mean difference (SMD) was determined using the random effects model, and heterogeneity was quantified using Higgins’ I2 statistics. Egger’s test and funnel plot were performed to measure bias. Furthermore, a sensitivity analysis was performed to determine the small study effect.ResultsInitially 39, 222 articles were identified. After screening of the entire methodology, 22 articles with 14,041 study participants (6,146 T2DM, 416 T1DM patients and 7,479 healthy controls) were included in this study. The pooled SMD in TLC (109/L) was 0.66 and −0.21, in T2DM and T1DM, respectively. Differences in absolute differential WBC counts for neutrophils, eosinophils, basophils, lymphocytes and monocytes in T2DM were 0.84, −1.59, 3.20, 0.36 and 0.26, respectively. The differences in relative differential counts (%) in T2DM were as follows: neutrophils: 1.31, eosinophils: −0.99, basophils: 0.34, lymphocytes: −0.19 and monocyte: −0.64. The SMD of differential counts of WBC (109/L) parameters; neutrophils, lymphocytes, monocytes and basophils in T1DM were −0.10, −0.69, 0.19, and −0.32, respectively. The pooled SMD in RBC parameters in T2DM were as follows: RBC: −0.57 (106/μL), Hb: −0.73 g/dL and HCT: −1.22%, Where as in T1DM RBC, Hb and HCT were −1.23 (106/μL), −0.80 g/dL and −0.29%, respectively.ConclusionPatients with T2DM had significantly increased TLC counts, absolute neutrophil, basophil, lymphocyte, monocyte counts and relative counts of neutrophils and basophils in comparison to controls. On the contrary, the absolute eosinophil count and relative lymphocyte, eosinophil and monocyte counts were decreased. In T1DM, WBC parameters were significantly decreased except monocytes. RBC parameters were found to be significantly decreased in T2DM patients. In T1DM, Hb and HCT were significantly decreased. However, there is no significant difference in RBC as compared with non-diabetic controls. The findings indicated a significant alteration of WBC and RBC parameters in both diabetic patients suggesting the considerable metabolic effect of diabetes on hematologic parameters.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/export_details_pdf.php, identifier [CRD42023413486].

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Platelet parameters: Can they serve as biomarkers of glycemic control or development of complications in evaluation of type 2 diabetes mellitus?

Cited by 14 publications

References 0 publications

Basic Coagulation Profiles and Platelet Parameters Among Adult Type 1 and Type 2 Diabetes Patients at Dessie Referral Hospital, Northeast Ethiopia: Comparative Cross-Sectional Study

Basic Coagulation Profiles and Platelet Parameters Among Adult Type 1 and Type 2 Diabetes Patients at Dessie Referral Hospital, Northeast Ethiopia: Comparative Cross-Sectional Study

The acute effect of a moderate intensity ergocycle exercise on the coagulation parameters in type 2 diabetes mellitus patients: a feasibility study

Changes in selected hematological parameters in patients with type 1 and type 2 diabetes: a systematic review and meta-analysis

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