Platelet Parameters in Children with Upper Urinary Tract Infection: Is There a Specific Response?

Abstract

Although complete blood count is routinely ordered in most upper urinary tract infections (UTI), and information regarding the patient's platelet indices is made available without added cost, the relationship between platelet count and mean platelet volume (MPV) and specific platelet responses to different infectious agents has not been extensively characterized in UTI. The objectives of this study were to examine platelet counts and platelet indices in children with culture-proven upper UTI to determine if there are organism-specific platelet responses. A retrospective analysis of data from all pediatric urine samples processed at Fatih University Medical School microbiology laboratory was undertaken for a period of two years (January 1, 2005, to December 31, 2006. Of the 200 patients with positive urine cultures, 146 (73%) were infected with gram-negative bacteria and 54 (27%) grew gram-positive bacteria. The platelet count during the episode of upper UTI and the incidence of thrombocytosis was significantly higher with the gram-positive infections than with the gram-negative infections or controls (p < 0.05). A statistically significant higher MPV was detected in the subjects with upper UTI (p < 0.05). Also, our data showed a statistically significant increase in MPV with gram-positive infections compared with the other groups (p < 0.05). In conclusion, based on the importance of the hemostatic component in the pathophysiology of infections, our findings of platelet count and MPV and predictivity of the type of the organism would suggest the usefulness of the routine measurements in children with upper UTI.

Evaluation of mean platelet volume (MPV) levels in brucellosis patients

“…Çatal et al [41] reported a significant correlation between urinary infection and MPV elevation. Kucukbayrak reported that postoperative MPV levels were lower than preoperative levels in patients with hydatid cyst [24].…”

Does Mean Platelet Volume in Children with Bronchiectasis Predict Exacerbations?

“…21 In addition, an increase in levels of MPV in acute upper urinary tract infectious were reported. 22 Increased MPV levels might be detected as a result of either the development of more invasive disease or the unreponsiveness to the antibiotic treatment. 23 The variety in results might be related to methodological differences in study designs.…”

Çocuklarda trombosit belirteçleri ve febril konvülziyon arasındaki ilişki

“…This finding shows that more inflammatory changes occur in the acute phase of disease activity in the brain in the complex FS. Arıca et al compared the MPVs levels in children diagnosed with FMF, during attack and attack-free periods and they reported that during acute attacks, the MPV values in children with FMF were rising as the disease severity score increased 27 .…”

“…In support of this observation, some studies have suggested that cytokines, such as IL-3 and IL-6, which play a role in the inflammatory process, may influence megakaryocyte ploidy and lead to the production of larger and more reactive platelets, thus affecting the MPV 22 . The relationship between MPV and infection, especially sepsis, has also been evaluated in a number of studies [23][24][25] . Robbins et al reported that at least two patterns of platelet size changes are possible in response to infection (an early rise in MPV in severe infections, such as septicemia (may be associated with thrombocytopenia); and a later decrease in MPV with a sustained, chronic, or persistent bacterial infection (may be associated with thrombocytosis) 26 .…”